Las células linfoides innatas y su papel en la regulación de la respuesta inmune

Bibiana Patricia Ruiz Sánchez, David Cruz Zárate, Iris Estrada García, Isabel Wong Baeza

Resumen


Las células linfoides innatas (ILC) son linfocitos que carecen de receptores de reconocimiento de antígenos y se activan en respuesta a citocinas y a través de receptores de patrones moleculares asociados a microorganismos (MAMP). Las ILC se localizan preferentemente en las mucosas, y participan en la respuesta inmune contra infecciones y en enfermedades inflamatorias crónicas. Las ILC se dividen en ILC-1, ILC-2 e ILC-3, y estas células tienen funciones análogas a las de los linfocitos Th1, Th2 y Th17 de la respuesta inmune adaptativa. Las ILC-1 expresan T-bet, producen IFNγ, protegen contra infecciones con microorganismos intracelulares y están relacionados con la inmunopatología de la enfermedad inflamatoria intestinal. Las ILC-2 expresan GATA3, producen IL-4, IL-5, IL-13 y anfirregulina, protegen contra infecciones parasitarias y se relacionan con la inmunopatología de la alergia y la obesidad. Las ILC-3 expresan RORγt, producen IL-17 e IL-22, protegen contra infecciones con hongos y participan en la tolerancia a la microbiota intestinal y en la reparación intestinal. Se relacionan con la inmunopatología de la enfermedad inflamatoria intestinal y la psoriasis. En términos generales, las ILC mantienen la homeostasis y coadyuvan en la protección contra las infecciones.


Palabras clave


Células linfoides innatas; Infección; Respuesta inmune; Inflamación crónica

Texto completo:

PDF PubMed

Referencias


Rajamuthiah R, Mylonakis E. Effector triggered immunity. Virulence. 2014;5(7):697-702. DOI: http://dx.doi.org/10.4161/viru.29091

Netea MG, Latz E, Mills KH, O’Neill LA. Innate immune memory: a paradigm shift in understanding host defense. Nat Immunol. 2015;16(7):675-679. DOI: http://dx.doi.org/10.1038/ni.3178

Sonnenberg GF, Fouser LA, Artis D. Border patrol: Regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22. Nat Immunol. 2011;12(5):383-390. DOI: http://dx.doi.org/10.1038/ni.2025

Inaba K, Steinman RM. Protein-specific helper T-lymphocyte formation initiated by dendritic cells. Science. 1985;229(4712):475-479. DOI: http://dx.doi.org/10.1126/science.3160115

Dumonde DC, Wolstencroft RA, Panayi GS, Matthew M, Morley J, Howson WT. “Lymphokines”: Non-antibody mediators of cellular immunity generated by lymphocyte activation. Nature. 1969;224(5214):38-42. DOI: http://dx.doi.org/10.1038/224038a0

Rosenau W, Moon HD. Lysis of homologous cells by sensitized lymphocytes in tissue culture. J Natl Cancer Inst. 1961;27(2):471-483. http://dx.doi.org/10.1093/jnci/27.2.471

Nossal GJV, Lederberg J. Antibody production by single cells. Nature. 1958;181(4620):1419-1420. DOI: http://dx.doi.org/10.1038/1811419a0

Jerne NK, Nordin AA. Plaque formation in Agar by single antibody-producing cells. Science. 1963;140(3565):405. DOI: http://dx.doi.org/10.1126/science.140.3565.405

Parkin J, Cohen B. An overview of the immune system. Lancet. 2001;357(9270):1777-1789. DOI: http://dx.doi.org/10.1016/S0140-6736(00)04904-7

Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, et al. Innate lymphoid cells-a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13(2):145-149. DOI: http://dx.doi.org/10.1038/nri3365

Spits H, Di-Santo JP. The expanding family of innate lymphoid cells: Regulators and effectors of immunity and tissue remodeling. Nat Immunol. 2011;12(1):21-27. DOI: http://dx.doi.org/10.1038/ni.1962

Eberl G. Development and evolution of RORgammat+ cells in a microbe’s world. Immunol Rev. 2012;245(1):177-188. DOI: http://dx.doi.org/10.1111/j.1600-065X.2011.01071.x

McKenzie ANJ, Spits H, Eberl G. Innate lymphoid cells in inflammation and immunity. Immunity. 2014;41(3):366-374. DOI: http://dx.doi.org/10.1016/j.immuni.2014.09.006

Kiessling R, Klein E, Wigzell H. “Natural” killer cells in the mouse. I. Cytotoxic cells with specificity for mouse Moloney leukemia cells. Specificity and distribution according to genotype. Eur J Immunol. 1975;5(2):112-117. DOI: http://dx.doi.org/10.1002/eji.1830050208

Kiessling R, Petranyi G, Kärre K, Jondal M, Tracey D, Wigzell H. Killer cells: A functional comparison between natural, immune T-cell and antibody-dependent in vitro systems. J Exp Med. 1976;143(4):772-780. DOI: http://dx.doi.org/10.1084/jem.143.4.772

Finke D. Fate and function of lymphoid tissue inducer cells. Curr Opin Immunol. 2005;17(2):144-150. DOI: http://dx.doi.org/10.1016/j.coi.2005.01.006

Kelly KA, Scollay R. Seeding of neonatal lymph nodes by T cells and identification of a novel population of CD3-CD4+ cells. Eur J Immunol. 1992;22(2):329-334. DOI: http://dx.doi.org/10.1002/eji.1830220207

Eberl G, Marmon S, Sunshine MJ, et al. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol. 2004;5(1):64-73. DOI: http://dx.doi.org/10.1038/ni1022

Satoh-Takayama N, Vosshenrich CA, Lesjean-Pottier S, Sawa S, Lochner M, Rattis F, et al. Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense. Immunity. 2008;29(6):958-970. DOI: http://dx.doi.org/10.1016/j.immuni.2008.11.001

Cella M, Fuchs A, Vermi W, Facchetti F, Otero K, Lennerz JK, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457(7230):722-725. DOI: http://dx.doi.org/10.1038/nature07537

Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature. 2010;463(7280):540-544. DOI: http://dx.doi.org/10.1038/nature08636

Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly Maria, Langford TKA, et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature. 2010;464(7293):1367-1370. DOI: http://dx.doi.org/10.1038/nature08900

Price AE, Liang HE, Sullivan BM, Reinhardt RL, Eisley CJ, Erle DJ, et al. Systemically dispersed innate IL-13-expressing cells in type 2 immunity. Proc Natl Acad Sci U S A. 2010;107(25):11489-11494. DOI: http://dx.doi.org/10.1073/pnas.1003988107

Klose CS, Flach M, Mohle L, Rogell L, Hoyler T, Ebert K, et al. Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell. 2014;157(2):340-356. DOI: http://dx.doi.org/10.1016/j.cell.2014.03.030

Serafini N, Vosshenrich CA, Di Santo JP. Transcriptional regulation of innate lymphoid cell fate. Nat Rev Immunol. 2015;15(7):415-428. DOI: http://dx.doi.org/10.1038/nri3855

Sonnenberg GF. Regulation of intestinal health and disease by innate lymphoid cells. Int Immunol. 2014;26(9):501-507. DOI: http://dx.doi.org/10.1093/intimm/dxu052

Krueger PD, Narayanan S, Surette FA, Brown MG, Sung SJ, Hahn YS. Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells. J Leukoc Biol. 2017;101(1):329-338. DOI: http://dx.doi.org/10.1189/jlb.3A0516-225R

Cortez VS, Robinette ML, Colonna M. Innate lymphoid cells: New insights into function and development. Curr Opin Immunol. 2015;32:71-77. DOI: http://dx.doi.org/10.1016/j.coi.2015.01.004

Monticelli LA, Sonnenberg GF, Abt MC, Alenghat T, Ziegler CG, Doering TA, et al. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus. Nat Immunol. 2011;12(11):1045-1054. DOI: http://dx.doi.org/10.1031/ni.2131

Carrega P, Loiacono F, Di Carlo E, Scaramuccia A, Mora M, Conte R, et al. NCR(+)ILC-3 concentrate in human lung cancer and associate with intratumoral lymphoid structures. Nat Commun. 2015;6:8280. DOI: http://dx.doi.org/10.1038/ncomms9280

Xu H, Wang X, Lackner AA, Veazey RS. Type 3 innate lymphoid cell depletion is mediated by TLRs in lymphoid tissues of simian immunodeficiency virus-infected macaques. FASEB J. 2015;29(12):5072-5080. DOI: http://dx.doi.org/10.1096/fj.15-276477

Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, et al. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science. 2014;343(6169):432-437. DOI: http://dx.doi.org/10.1126/science.1247606

Withers DR. Innate lymphoid cell regulation of adaptive immunity. Immunology. 2016;149(2):123-130. DOI: http://dx.doi.org/10.1111/imm.12639

Vély F, Barlogis V, Vallentin B, Neven B, Piperoglou C, Ebbo M, et al. Evidence of innate lymphoid cell redundancy in humans. Nat Immunol. 2016;17(11):1291-1299. DOI: http://dx.doi.org/10.1038/ni.3553

Diefenbach A. Innate lymphoid cells in the defense against infections. Eur J Microbiol Immunol (Bp). 2013;3(3):143-151. DOI: http://dx.doi.org/10.1556/EuJMI.3.2013.3.1

Eberl G, Colonna M, Di Santo JP, McKenzie AN. Innate lymphoid cells. Innate lymphoid cells: A new paradigm in immunology. Science. 2015;348(6237):aaa6566. DOI: http://dx.doi.org/10.1126/science.aaa6566

Erick TK, Brossay L. Phenotype and functions of conventional and non-conventional NK cells. Curr Opin Immunol. 2016;38:67-74. DOI: http://dx.doi.org/10.1016/j.coi.2015.11.007

Montel AH, Bochan MR, Hobbs JA, Lynch DH, Brahmi Z. Fas involvement in cytotoxicity mediated by human NK cells. Cell Immunol. 1995;166(2):236-246. DOI: http://dx.doi.org/10.1006/cimm.1995.9974

Poli A, Michel T, Théresine M, Andrès E, Hentges F, Zimmer J. CD56bright natural killer (NK) cells: An important NK cell subset. Immunology. 2009;126(4):458-465. DOI: http://dx.doi.org/10.1111/j.1365-2567.2008.03027.x

Spits H, Bernink JH, Lanier L. NK cells and type 1 innate lymphoid cells: Partners in host defense. Nat Immunol. 2016;17(7):758-764. DOI: http://dx.doi.org/10.1038/ni.3482

Hoyler T, Klose CS, Souabni A, Turqueti-Neves A, Pfeifer D, Rawlins EL, et al. The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. Immunity. 2012;37(4):634-648. DOI: http://dx.doi.org/10.1016/j.immuni.2012.06.020

Kita H. ILC2s and fungal allergy. Allergol Int. 2015;64(3):219-226. DOI: http://dx.doi.org/10.1016/j.alit.2015.04.004

Juelke K, Romagnani C. Differentiation of human innate lymphoid cells (ILCs). Curr Opin Immunol. 2016;38:75-85. DOI: http://dx.doi.org/10.1016/j.coi.2015.11.005

Doherty TA, Khorram N, Lund S, Mehta AK, Croft M, Broide DH. Lung type 2 innate lymphoid cells express cysteinyl leukotriene receptor 1, which regulates TH2 cytokine production. J Allergy Clin Immunol. 2013;132(1):205-213. DOI: http://dx.doi.org/10.1016/j.jaci.2013.03.048

Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013;5(174):174ra126. DOI: http://dx.doi.org/10.1126/scitranslmed.3004812

Mjösberg J, Bernink J, Golebski K, Karrich JJ, Peters CP, Blom B, et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity. 2012;37(4):649-659. DOI: http://dx.doi.org/10.1016/j.immuni.2012.08.015

Klein-Wolterink RG, Serafini N, Van-Nimwegen M, Vosshenrich CA, De-Bruijn MJ, Fonseca Pereira D, et al. Essential, dose-dependent role for the transcription factor Gata3 in the development of IL-5+ and IL-13+ type 2 innate lymphoid cells. Proc Natl Acad Sci U S A. 2013;110(25):10240-10245. DOI: http://dx.doi.org/10.1073/pnas.1217158110

Furusawa J, Moro K, Motomura Y, Okamoto K, Zhu J, Takayanagi H, et al. Critical role of p38 and GATA3 in natural helper cell function. J Immunol. 2013;191(4):1818-1826. DOI: http://dx.doi.org/10.4049/jimmunol.1300379

Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, et al. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 2009;206(1):35-41. DOI: http://dx.doi.org/10.1084/jem.20072713

Guo X, Liang Y, Zhang Y, Lasorella A, Kee BL, Fu YX. Innate lymphoid cells control early colonization resistance against Intestinal pathogens through ID2-dependent regulation of the microbiota. Immunity. 2015;42(4):731-743. DOI: http://dx.doi.org/10.1016/j.immuni.2015.03.012

Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, et al. Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. 2013;498(7452):113-117. DOI: http://dx.doi.org/10.1038/nature12240

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, et al. Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4(+) T cells. Science. 2015;348(6238):1031-1035. DOI: http://dx.doi.org/10.1126/science.aaa4812

Farkas AM, Ivanov, II. Escaping negative selection: ILC you in the gut. Immunity. 2015;43(1):12-14. DOI: http://dx.doi.org/10.1016/j.immuni.2015.07.006

Xu H, Wang X, Liu DX, Moroney-Rasmussen T, Lackner AA, Veazey RS. IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques. Mucosal Immunol. 2012;5(6):658-669. DOI: http://dx.doi.org/10.1038/mi.2012.39

Sanos SL, Bui VL, Mortha A, Oberle K, Heners C, Johner C, et al. RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22-producing NKp46+ cells. Nat Immunol. 2009;10(1):83-91. DOI: http://dx.doi.org/10.1038/ni.1684

Sonnenberg GF, Artis D. Innate lymphoid cell interactions with microbiota: Implications for intestinal health and disease. Immunity. 2012;37(4):601-610. DOI: http://dx.doi.org/10.1016/j.immuni.2012.10.003

Mielke LA, Jones SA, Raverdeau M, Higgs R, Stefanska A, Groom JR, et al. Retinoic acid expression associates with enhanced IL-22 production by gammadelta T cells and innate lymphoid cells and attenuation of intestinal inflammation. J Exp Med. 2013;210(6):1117-1124. DOI: http://dx.doi.org/10.1084/jem.20121588

Buonocore S, Ahern PP, Uhlig HH, Ivanov II, Littman DR, Maloy KJ, et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature. 2010;464(7293):1371-1375. DOI: http://dx.doi.org/10.1038/nature08949

Van Maele L, Carnoy C, Cayet D, Ivanov S, Porte R, Deruy E, et al. Activation of Type 3 innate lymphoid cells and interleukin 22 secretion in the lungs during streptococcus pneumoniae infection. J Infect Dis. 2014;210(3):493-503. DOI: http://dx.doi.org/10.1093/infdis/jiu106

Klose CS, Kiss EA, Schwierzeck V, Ebert K, Hoyler T, D’Hargues Y, et al. A T-bet gradient controls the fate and function of CCR6-RORgammat+ innate lymphoid cells. Nature. 2013;494(7436):261-265. DOI: http://dx.doi.org/10.1038/nature11813

Colonna M. Immunology: An innate regulatory cell. Nature. 2013;498(7452):42-43. DOI: http://dx.doi.org/10.1038/498042a

Walker JA, Barlow JL, McKenzie AN. Innate lymphoid cells. How did we miss them. Nat Rev Immunol. 2013;13(2):75-87. DOI: http://dx.doi.org/10.1038/nri3349

Neill DR, McKenzie AN. Nuocytes and beyond: new insights into helminth expulsion. Trends Parasitol. 2011;27(5):214-221. DOI: http://dx.doi.org/10.1016/j.pt.2011.01.001

Maizels RM, Hewitson JP, Smith KA. Susceptibility and immunity to helminth parasites. Curr Opin Immunol. 2012;24(4):459-466. DOI: http://dx.doi.org/10.1016/j.coi.2012.06.003

Artis D, Wang ML, Keilbaugh SA, He W, Brenes M, Swain GP, et al. RELMbeta/FIZZ2 is a goblet cell-specific immune-effector molecule in the gastrointestinal tract. Proc Natl Acad Sci U S A. 2004;101(37):13596-13600. DOI: http://dx.doi.org/10.1073/pnas.0404034101

Maizels RM, Withers DR. MHC-II: a mutual support system for ILCs and T cells. Immunity. 2014;41(2):174-176. DOI: http://dx.doi.org/10.1016/j.immuni.2014.07.006

Boyd A, Ribeiro JM, Nutman TB. Human CD117 (cKit)+ innate lymphoid cells have a discrete transcriptional profile at homeostasis and are expanded during filarial infection. PLoS One. 2014;9(9):e108649. DOI: http://dx.doi.org/10.1371/journal.pone.0108649

Gladiator A, Wangler N, Trautwein-Weidner K, LeibundGut-Landmann S, et al. Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection. J Immunol. 2013;190(2):521-525. DOI: http://dx.doi.org/10.4049/jimmunol.1202924

Valero A, Quirce S, Dávila I, Delgado J, Domínguez-Ortega J. Allergic respiratory disease: different allergens, different symptoms. Allergy. 2017;72(9):1306-1316. DOI: http://dx.doi.org/10.1111/all.13141

Sonnenberg GF, Artis D. Innate lymphoid cells in the initiation, regulation and resolution of inflammation. Nat Med. 2015;21(7):698-708. DOI: http://dx.doi.org/10.1038/nm.3892

Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs. J Immunol. 2012;188(3):1503-1513. DOI: http://dx.doi.org/10.4049/jimmunol.1102832

Chang YJ, Kim HY, Albacker LA, Baumgarth N, McKenzie AN, Smith DE, et al. Innate lymphoid cells mediate influenza-induced airway hyper-reactivity independently of adaptive immunity. Nat Immunol. 2011;12(7):631-638. DOI: http://dx.doi.org/10.1038/ni.2045

Li H, Richert-Spuhler LE, Evans TI, Gillis J, Connole M, Estes JD, et al. Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection. PLoS Pathog. 2014;10(12):e1004551. DOI: http://dx.doi.org/10.1371/journal.ppat.1004551

Mudd JC, Brenchley JM. ILC you later: Early and irreparable loss of innate lymphocytes in HIV infection. Immunity. 2016;44(2):216-218. DOI: http://dx.doi.org/10.1016/j.immuni.2016.01.022

Klose CS, Artis D. Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis. Nat Immunol. 2016;17(7):765-774. DOI: http://dx.doi.org/10.1038/ni.3489

Russell SE, Walsh PT. Sterile inflammation - do innate lymphoid cell subsets play a role. Front Immunol. 2012;3:246. DOI: http://dx.doi.org/10.3389/fimmu.2012.00246

Cording S, Medvedovic J, Aychek T, Eberl G. Innate lymphoid cells in defense, immunopathology and immunotherapy. Nat Immunol. 2016;17(7):755-757. DOI: http://dx.doi.org/10.1038/ni.3448

Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. 2015;519(7542):242-246. DOI: http://dx.doi.org/10.1038/nature14115

Flach M, Diefenbach A. Adipose tissue: ILC-2 crank up the heat. Cell Metab. 2015;21(2):152-153. DOI: http://dx.doi.org/10.1016/j.cmet.2015.01.015

Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013;210(3):535-549. DOI: http://dx.doi.org/10.1084/jem.20121964

Marchesi JR, Adams DH, Fava F, Hermes GDA, Hirschfield GM, Hold G, et al. The gut microbiota and host health: A new clinical frontier. Gut. 2016;65(2):330-339. DOI: http://dx.doi.org/10.1136/gutjnl-2015-309990

Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, et al. Interleukin 6 increases production of cytokines by colonic innate lymphoid cells in mice and patients with chronic intestinal inflammation. Gastroenterology. 2015;149(2):456-467.e15. DOI: http://dx.doi.org/10.1053/j.gastro.2015.04.017

Van-Der-Gracht E, Zahner S, Kronenberg M. When insult is added to injury: Cross talk between ILCs and intestinal epithelium in IBD. Mediators Inflamm. 2016;2016:9765238. DOI: http://dx.doi.org/10.1155/2016/9765238.

Park CO, Noh S, Jin S, Lee NR, Lee YS, Lee H, et al. Insight into newly discovered innate immune modulation in atopic dermatitis. Exp Dermatol. 2013;22(1):6-9. DOI: http://dx.doi.org/10.1111/exd.12034

Salimi M, Barlow JL, Saunders SP, Xue L, Gutowska-Owsiak D, Wang X, et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013;210(13):2939-2950. DOI: http://dx.doi.org/10.1084/jem.20130351

Pantelyushin S, Haak S, Ingold B, Kulig P, Heppner FL, Navarini AA, et al. Rorgammat+ innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest. 2012;122(6):2252-2256. DOI: http://dx.doi.org/10.1172/JCI61862

Pasparakis M, Haase I, Nestle FO. Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014;14(5):289-301. DOI: http://dx.doi.org/10.1038/nri3646

Villanova F, Flutter B, Tosi I, Grys K, Sreeneebus H, Perera GK, et al. Characterization of innate lymphoid cells in human skin and blood demonstrates increase of NKp44+ ILC-3 in psoriasis. J Invest Dermatol. 2014;134(4):984-991. DOI: http://dx.doi.org/10.1038/jid.2013.477

Vargas-Becerra MH. Fisiopatología del asma. Neumol Cir Torax. 2009;68(2):111-115. Disponible en: http://www.medigraphic.com/pdfs/neumo/nt-2009/nts092e.pdf

Matsuoka T, Shamji MH, Durham SR. Allergen immunotherapy and tolerance. Allergol Int. 2013;62(4):403-413. DOI: http://dx.doi.org/10.2332/allergolint.13-RAI-0650

Chang YJ, DeKruyff RH, Umetsu DT. The role of type 2 innate lymphoid cells in asthma. J Leukoc Biol. 2013;94(5):933-940. DOI: http://dx.doi.org/10.1189/jlb.0313127

Cheng H, Jin C, Wu J, Zhu S, Liu YJ, Chen J. Guards at the gate: Physiological and pathological roles of tissue-resident innate lymphoid cells in the lung. Protein Cell. 2017. DOI: http://dx.doi.org/10.1007/s13238-017-0379-5

Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, et al. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211-1221. DOI: http://dx.doi.org/10.1056/NEJMoa0906312

Kim HY, Chang YJ, Subramanian S, Lee HH, Albacker LA, Matangkasombut P, et al. Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity. J Allergy Clin Immunol. 2012;129(1):216-227. e1-6. DOI: http://dx.doi.org/10.1016/j.jaci.2011.10.036

Deckers J, Branco Madeira F, Hammad H. Innate immune cells in asthma. Trends Immunol. 2013;34(11):540-547. DOI: http://dx.doi.org/10.1016/j.it.2013.08.004

Halim TY, Krauss RH, Sun AC, Takei F. Lung natural helper cells are a critical source of Th2 cell-type cytokines in protease allergen-induced airway inflammation. Immunity. 2012;36(3):451-463. DOI: http://dx.doi.org/10.1016/j.immuni.2011.12.020

Wilhelm C, Hirota K, Stieglitz B, Van-Snick J, Tolaini M, Lahl K, et al. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol. 2011;12(11):1071-1077. DOI: http://dx.doi.org/10.1038/ni.2133

Klein-Wolterink RG, Kleinjan A, Van-Nimwegen M, Bergen I, De-Bruijn M, Levani Y, et al. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma. Eur J Immunol. 2012;42(5):1106-1116. DOI: http://dx.doi.org/10.1002/eji.201142018

Kim BS, Wojno ED, Artis D. Innate lymphoid cells and allergic inflammation. Curr Opin Immunol. 2013;25(6):738-744. DOI: http://dx.doi.org/10.1016/j.coi.2013.07.013

Holtzman MJ, Byers DE, Alexander-Brett J, Wang X. The role of airway epithelial cells and innate immune cells in chronic respiratory disease. Nat Rev Immunol. 2014;14(10):686-698. DOI: http://dx.doi.org/10.1038/nri3739

Martinez-Gonzalez I, Mathä L, Steer CA, Takei F. Immunological memory of group 2 innate lymphoid cells. Trends Immunol. 2017;38(6):423-431. DOI: http://dx.doi.org/10.1016/j.it.2017.03.005

Sutherland ER, Lehman EB, Teodorescu M, Wechsler ME. Body mass index and phenotype in subjects with mild-to-moderate persistent asthma. J Allergy Clin Immunol. 2009;123(6):1328-1334.e1. DOI: http://dx.doi.org/10.1016/j.jaci.2009.04.005

Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, et al. IL-17 producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nat Med. 2014;20(1):54-61. DOI: http://dx.doi.org/10.1038/nm.3423

Hulse KE. Immune mechanisms of chronic rhinosinusitis. Curr Allergy Asthma Rep. 2016;16(1):1. DOI: http://dx.doi.org/10.1007/s11882-015-0579-0

Zuo J, Shan Z, Zhou L, Yu J, Liu X, Gao Y. Increased CD160 expression on circulating natural killer cells in atherogenesis. J Transl Med. 2015;13:188. DOI: http://dx.doi.org/10.1186/s12967-015-0564-3

Engelbertsen D, Foks AC, Alberts-Grill N, Kuperwaser F, Chen T, Lederer JA, et al. Expansion of CD25+ innate lymphoid cells reduces atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35(12):2526-2535. DOI: http://dx.doi.org/10.1161/ATVBAHA.115.306048

Mattner J, Wirtz S. Friend or foe? The ambiguous role of innate lymphoid cells in cancer development. Trends Immunol. 2017;38(1):29-38. DOI: http://dx.doi.org/10.1016/j.it.2016.10.004

Li J, Razumilava N, Gores GJ, Walters S, Mizuochi T, Mourya R, et al. Biliary repair and carcinogenesis are mediated by IL-33-dependent cholangiocyte proliferation. J Clin Invest. 2014;124(7):3241-3251. DOI: http://dx.doi.org/10.1172/JCI73742

Jovanovic IP, Pejnovic NN, Radosavljevic GD, Pantic JM, Milovanovic MZ, Arsenijevic NN, et al. Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells. Int J Cancer. 2014;134(7):1669-1682. DOI: http://dx.doi.org/10.1002/ijc.28481

Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, et al. Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells. Mucosal Immunol. 2014;7(4):842-856. DOI: http://dx.doi.org/10.1038/mi.2013.101

Carrega P, Campana S, Bonaccorsi I, Ferlazzo G. The yin and yang of innate lymphoid cells in cancer. Immunol Lett. 2016;179:29-35. DOI: http://dx.doi.org/10.1016/j.imlet.2016.06.003

Gowans JL. The recirculation of lymphocytes from blood to lymph in the rat. J Physiol. 1959;146(1):54-69. DOI: http://dx.doi.org/10.1113/jphysiol.1959.sp006177

Reinherz EL, Kung PC, Breard JM, Goldstein G, Schlossman SF. T cell requirements for generation of helper factor(s) in man: Analysis of the subsets involved. J Immunol. 1980;124(4):1883-1887.

Nomenclature for clusters of differentiation (CD) of antigens defined on human leukocyte populations. IUIS-WHO Nomenclature Subcommittee. Bull World Health Organ. 1984;62(5):809-815. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2536217/

Bernard A, Boumsell L. The clusters of differentiation (CD) defined by the First International Workshop on Human Leucocyte Differentiation Antigens. Hum Immunol. 1984;11(1):1-10. DOI: http://dx.doi.org/10.1016/0198-8859(84)90051-X

Mosmann TR, Coffman RL. Two types of mouse helper T-cell clone implications for immune regulation. Immunol Today. 1987;8(7-8):223-227. DOI: http://dx.doi.org/10.1016/0167-5699(87)90171-X


Enlaces refback

  • No hay ningún enlace refback.