PRURITO CRÓNICO

Ana María Villa-Arango, Margarita Velásquez-Lopera, Ricardo Cardona-Villa

Resumen


El prurito crónico se define como una sensación no placentera de la piel que induce el rascado y que dura más de seis semanas. Este síntoma puede ser la manifestación de una enfermedad cutánea o sistémica y tiene un importante compromiso de la calidad de vida de los pacientes, alterando de forma consistente el sueño y las actividades diarias.

La fisiopatología es compleja e incluye múltiples mediadores y sus respectivos receptores, que, a través de diferentes vías de señalización, llevan información por las fibras nerviosas tipo C hacia el tálamo, desde donde se distribuye a diversas zonas de la corteza cerebral. La comprensión de estos mecanismos, ha permitido identificar posibles blancos terapéuticos y el desarrollo de moléculas cada vez más efectivas y seguras para los pacientes. La presente revisión pretende dar una visión acerca del abordaje diagnóstico y terapéutico de los pacientes con prurito crónico.



Palabras clave


prurito, prurito crónico, comezón, dermatosis

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DOI: http://dx.doi.org/10.29262/ram.v65i1.345

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