DIAGNOSIS OF ALLERGIC SENSITIZATION IN PATIENTS WITH ALLERGIC RHINITIS AND ASTHMA IN A TROPICAL ENVIRONMENT

Mario Alfredo Sánchez Borges

Resumen


Background: Few studies in tropical and developing countries have utilized molecular diagnosis to characterize allergen-specific responses to aeroallergens.

Objective: To investigate the in vivo and in vitro IgE responses to inhalant allergens in allergic patients suffering rhinitis and/or asthma.

Methods: Patients with allergic rhinitis and/or asthma were included in this prospective, cross-sectional study. Skin prick tests with 16 inhalant extracts and allergen-specific IgE and component-specific IgE in the serum were investigated.

Results: One hundred and eighty nine patients were studied. Increased levels of total serum IgE were present in 73.5 % of the patients. Positive STs to mite extracts were present in more than 60 % of the patients, followed by cat (29.6 %), dog (23.4 %), and Periplaneta americana (21.6 %). Specific IgE for Dermatophagoides farinae and pteronyssinus was present in 66.6 % of patients, for Blomia tropicalis in 45.0 %, for Ascaris lumbricoides in 24.7 %, for cat in 17.3 %, for budgerigar feathers in 14.8 %, for Penicillium notatum in 12.3 %. IgE antibodies to group 1 and 2 mite allergens were present in 59.0 % to 70.1 % of the sera, whereas 39.1 % contained IgE to rBlo t5, 30.4 % to rBla g4, 19.9 % to rFel d1, 11.8 % to rArt v3, 11.2 % to Der p10, 9.9 % to rBla g2, 9.3 % to rPer a7, 9.3 % to nFel d2, and 8.7 % to rCan f1.

Conclusion: This study confirms the importance of mite allergens as major sensitizing agents in patients with respiratory allergic diseases in the tropical environment. Generally there was a good correlation between skin testing and in vitro testing.


Palabras clave


Aeroallergens. Asma. Component resolved diagnosis. CRD. Immunoglobulin E. Rhinitis.

Referencias


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DOI: http://dx.doi.org/10.29262/ram.v65i1.570

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