Vitaminas antioxidantes en asma

Columba Citlalli Barrera Mendoza, Francisco Ayala Mata, Christian Cortés Rojo, Martha Estrella García Pérez, Alain R Rodríguez-Orozco

Resumen


Antecedentes: El asma es una enfermedad de etiología desconocida, que cursa con inflamación crónica de las vías respiratorias. Las células que median la respuesta inflamatoria generan especies reactivas de oxígeno, mismas que en conjunto con otras especies oxidantes presentes de manera natural en las vías aéreas,  ocasiona la ruptura del equilibrio redox, generando así, estrés oxidativo. Se ha propuesto que éste puede revertirse por la administración de vitaminas antioxidantes tales como la A, C, E y D y de esta forma aliviar, mejorar o proteger a las personas asmáticas de los síntomas de esta enfermedad. Objetivos: revisar el estado del arte, con base en ensayos observacionales y controlados por placebo, del papel de las vitaminas antioxidantes en el curso del asma. Métodos: Se revisaron los artículos publicados en el periodo comprendido entre los años 1979 y 2016. Los motores de búsqueda fueron Google y Google Scholar; las bases de datos consultadas fueron PubMed y The Cochrane Library. Resultados: Se encontraron y revisaron 75 artículos relevantes para el tema. Conclusión: no está claro si la ingesta de suplementos de estas vitaminas tiene algún efecto clínico benéfico en el control del asma. Son necesarios más ensayos controlados y de mayor duración para elucidar definitivamente el papel de estos nutrientes en el curso del asma.

Palabras clave


vitaminas antioxidantes; asma; estrés oxidativo

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Referencias


The global asthma report 2014. Auckland, New Zeland: Global Asthma Network 2014

Han YY, Blatter J, Brehm JM, Forno E, Litonjua AA, Celedón JC. Diet and asthma: vitamins and methyl donors. Lancet Respir Med 2013; 1:813-822

Rebolledo-Cobos RC, Teixeira B, Correa C. Asma, estrés oxidativo y ejercicio físico: revisión de literatura. Fisioterapia 2014; 36:40-48.

Barnes PJ. Reactive oxygen species and airway inflammation. Free Radic Biol Med 1990;9:235-43.

Henricks PA, Nijkamp FP. Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 2001; 14:409-420

Riccioni G, Barbara M, Bucciarelli T, di Ilio C, D’Orazio N. Antioxidant vitamin supplementation in asthma. Ann Clin Lab Sci 2007; 37:96-101.

Rosanna DP, Salvatore C. reactive oxygen species, inflammation, and lung diseases. Curr Pharm Des 2012;18:3889-3900.

Martínez-Cayuela M. Oxygen free radicals and human disease. Biochimie 1995;77:147-161

Oberholzer HM, Pretorius E. The role of vitamins and minerals in the alleviation of asthma symptoms. Early Child Development and Care 2006; 180:913-920.

Rahman I, Biswas SK, Kode A. Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 2006; 533:222-239

Birben E, Sahiner, UM, Sackesen C. Et al. Oxidative stress and antioxidant defense. World Allergy Organ J 2012; 5:9-19

Moreno-Macías H, Romieu I. Effects of antioxidant supplements and nutrients on patients with asthma and allergies. J Allergy Clin Immunol 2014;133:1237-1244

Nadeem A, Chhabra SK, Masood A, et al. Increased levels of antioxidants in asthma. J Allergy Clin Immunol 2003;111:72-78

Sahiner UM, Birben E, Erzurum S, Sackesen C, Kalayci O. Oxidative stress in asthma. World Allergy Organ J 2011; 4:151-158

Patel BD, Welch AA, Bingham SA, Luben RN, Day NE, Khaw KT, Lomas DA, Wareham NJ. Dietary antioxidants and asthma in adults. Thorax 2006; 61:388-393.

Harik-Khan RI, Muller DC, Wise RA. Serum vitamin levels and the risk of asthma in children. Am J Epidemiol 2004;159:351-357.

Gilliland FD, Berhane KT, Li YF, Gauderman WJ, McConnell, R, Peters J. Children’s lung function and antioxidant vitamin, fruit, juice and vegetable intake. Am J Epidemiol 2003; 158:576-584.

Allen S, Britton JR, Leonardi-Bee JA. Association between antioxidant vitamins and asthma outcome measures: systematic review and meta-analysis. Thorax 2009; 64:610-619

Murr C, Schroecksnadel K, Winkler C et al. Antioxidants may increase the probability of developing allergic diseases and asthma. Med Hypotheses 2005;64:973-979

Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulm Pharmacol Ther 2015:32:60-74

Hollick MF. Photosynthesis of vitamin D in the skin: effect of environmental and life-style variables. Fed Proc 1987;46:1876-82.

Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010; 95:471-478

Watkins RR, Lemonovich TL, Salata RA. An update on the association of vitamin D deficiency with common infectous diseases. Can J Physiol Pharmacol 2015;93:;363-368.

Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 2: a review of human studies. Pulm Pharmacol Ther 2015:32:75-92

Majak P, Jerzynska J, Smejda K, Stelmach I, Timler D, Stelmach W. Correlation of vitamin D with Foxp3 induction and steroid-sparing effect of immunotherapy in asthmatic children. Ann Allergy Asthma Immunol 2012;109:329-335

Tse SM, Kelly HW, Litonjua AA, Van Natta ML, Weiss ST, Tantisira KG, Childhood Asthma Management Program Research Group. Corticosteroid use and bone mineral accretion in children with asthma: effect modification by vitamin D. J Allergy Clin Immunol 2012;130:53-60.

Lewis E, Fernández C, Nella A, Hopp R, Gallagher JC, Casale TB. Relationship of 25-hydroxyvitamin D and asthma control in children. Ann Allergy Asthma Immunol 2012;108:281-282

Wagner CL, Greer FR, American Academy of Pediatrics Section on Breastfeeding, American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics 2008;122:1142–1152.

Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary reference intakes for adequacy: calcium and vitamin D. In: Ross AC, Taylor CL, Yaktine AL, et al.,editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press; 2011:345-402

Gimeno JE. Recomendaciones sobre cómo administrar la vitamina D. Guías internacionales y nacionales. Rev Osteoporos Metab Miner 2014;6:S19-S22

Määtä AM, Kotaniemi-Syrjänen A, Malmström K, et al. Vitamin D, high-sensitivity C-reactive protein, and airway hyperresponsiveness in infants with recurrent respiratory symptoms. Ann Allergy Asthma Immunol 2017; 119:227-231. 10.1016/j.anai.2017.06.014.

Van Oeffelen AAM, Bekkers MBM, Smit HA, Kerkhof M, Koppelman GH, Haveman-Nies A. van der A DL, Jansen EHJM, Wijga AH. Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 2011;22:784-793

Litonjua AA, Carey VJ, Laranjo N, Harshfield BJ, McElrath TF, O´Connor GT et al. Effect of prenatal supplementation with vitamin D on asthma or recurrent wheezing in offspring by age 3 years: the VDAART randomized clinical trial. JAMA 2016; 315:362-370.

Chawes BL, Bønnelykke K, Stokholm J, Vissing NH, Bjarnadóttir E, Schoos AMM. Effect of vitamin D3 supplementation during pregnancy on risk of persistent wheeze in the offspring. A randomized clinical trial. JAMA 2016;315:353-361

Von Mutius E, Martínez FD. Inconclusive results of randomized trials of prenatal vitamin d for asthma prevention in offspring: curbing the enthusiasm. JAMA 2016; 315:347-348

Hahn DL. Glucocorticosteroids are potential confounders in studies of vitamin D and asthma. Am J Respir Crit Care Med 2012;185:1245

Skversky AL, Kumar J, Abramowitz MK et al. Association of Glucocorticoid Use and Low 25-Hydroxyvitamin D Levels: Results from the National Health and Nutrition Examination Survey (NHANES): 2001–2006. J Clin Endocrinol Metab 2011;96:3838-3845

Schauber J, Dorschner RA, Coda AB, Buchau AS, Liu PT, Kiken D, et al. Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism. J Clin Invest 2007;117:803–11.

Schauber J, Gallo RL. Vitamin D and asthma: not a strong link-yet. J Allergy Clin Immunol 2008; 121:782-784

Martineau AR, Christopher JC, Mitsuyoshi U et al. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2016;9:CD011511

Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, Britton, J. Corticosteroid sparing effects of vitamin C and magnesium in asthma: a randomised trial. Respir Med 2006;100:174-179

Biltagi MA, Baset AA, Bassiouny M, Kasrawi M. Omega-3 fatty acids, vitamin C and Zn supplementation in asthmatic children: a randomized self-controlled study. Acta Paediatrica 2009;98:737-742

Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med 2007;101:1770-1778

McKeever M, Britton J. Diet and asthma. Am J Respir Crit Care Med 2004; 170:725-729.

Kaur B, Rowe BH, Ram FS. Vitamin C supplementation for asthma. Cochrane Database Systematic Review 2009.

Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, Britton, J. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo-controlled trial. Clin Exp Allergy 2003;33:1355-1359

Kordansky DW, Rosenthal RR, Norman PS. The effect of vitamin C on antigen-induced bronchospasm. J Allergy Clin Immunol 1979;63:61-64

Malo JL, Cartier A, Pineau L et al. Lack of acute effects of ascorbic acid on spirometry and airway responsiveness to histamine in subjects with asthma. J Allergy Clin Immunol 1986;78:1153-1158

Wilkinson M, Hart A, Milan SJ et al. Vitamins C and E for asthma and exercise-induced bronchoconstriction. Cochrane Database Syst Rev 2014;6:CD010749

Hernández M, Zhou H, Zhou B et al. Combination treatment with high dose vitamin C and alpha-tocopherol does not enhance respiratory-tract lining fluid vitamin C levels in asthmatics. Inhal Toxicol 2009;21:173-181

Brigelius-Flohé R, Traber MG. Vitamin E: functions and metabolism. FASEB J 1999; 10:1145-1155

Kollek I, Sinha P, Rüstow B. Vitamin E as an antioxidant of the Lung. Mechanisms of vitamin E delivery to alveolar type II cells. Am J Respir Crit Care Med 2002; 166:S62-S66

Wood LG, Garg ML, Blake RJ, Simpson JL, Gibson PG. Oxidized vitamin E and glutathione as markers of clinical status in asthma. Clin Nutr 2008;27:579-586

Mabalirajan U, Aich J, Leishangthem, GD, Sharma SK, Dinda, AK, Ghosh B. Effects of vitamin E on mitocondrial dysfunction and asthma features in an experimental allergic murine model. J Appl Physiol 2009; 107:1285-1292

Pearson PJK, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomized placebo controlled trial. Thorax 2004; 59:652-656

Berdnikovs S, Abdala-Valencia H, McCary C, Somand M, Cole R, García A, Bryce P, Cook-Mills JM. Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment. J immunol 2009; 182;4395-4405

Cook-Mills JM. Isoforms of vitamin E differentially regulate PKC α and inflammation: a review. J Clin Cell Immunol 2013;4:1000137

Feray J, Britton J. Dietary supplements and asthma: another one bites the dust. Thorax 2007; 62:466-468

Schuster GU, Kenyon NJ, Stephensen CB. Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol 2008; 180:1834-1842

Márquez HA, Cardoso WA. Vitamin A-retinoid signalling in pulmón development and disease. Mol Cell Pediatr 2016;3:28-32

Carraro S, Giordano G, Reniero F, Carpi D, Stocchero M, Sterk PJ, Baraldi E. Asthma severity in childhood and metabolomic profiling of breath condensate. Allergy 2013; 68:110-117

Neuman I, Nahum H, Ben-Amotz A. Prevention of exercise-induced asthma by a natural isomer mixture of beta-carotene. Ann Allergy Asthma Immunol 1999; 82:549-553

Neuman I, Nahum H, Ben-Amotz A. Reduction of exercise-induced asthma oxidative stress by lycopene, a natural antioxidant. Allergy 2000;55:1184-1189

Checkley W, West KP Jr, Wise RA, Baldwin MR, Wu L, LeClerq SC, Christian P, Katz J, Tielsch JM, Khatry S, Sommer A. Maternal vitamin A supplementation and lung function in offsprings. N Engl J Med 2010; 362:1782-1794

Checkley W, West KP, Wise RA et al. Supplementation with vitamin A early in life and subsequent risk of asthma. Eur Respir J 2011;38:1310-1319

Patel S, Murray CS, Woodcock A, Simpson A, Custovic A. Dietary antioxidant intake, allergic sensitization and allergic diseases in young children. Allergy 2009;64:1766-1772

Arora P, Kumar V, Batra S Vitamin A status in children with asthma. Pediatr Allergy Immunol 2002;13:223-226

Milner JD, Stein DM, McCarter R, Moon RY. Early infant supplementation is associated with increased risk for food allergy and asthma. Pediatrics 2004; 114:27-32

Arshi S, Fallahpour M, Nabavi M et al. The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma. Ann Allergy Asthma Immunol:Off Publ Am Coll Allergy Asthma Immunol 2014;113:404e9

Majak P, Malgorzata, OC, Smejda K, et al. Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection. J Allergy Clin Immunol 2011;127:1294-1296

Yadav M, Mittal K. Effect of vitamin D supplementation on moderate to severe bronchial asthma. Indian J Pediatr 2013; DOI 10.1007/s12098-013-1268-4

Castro M, King TS, Kunselman SJ et al. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA 2014;311:2083-2091

Bar YR, Livnat, G, Schnapp Z et al. The effect of vitamin D on airway reactivity and inflammation in asthmatic children: a double-blind placebo-controlled trial. Pediatr Pulmonol 2014.

Nanzer AM, Chambers ES, Ryanna K et al. The effects of calcitriol treatment in glucocorticoid-resistant asthma. J Allergy Clin Immunol 2014;133:1755-1777

Hemilä H, Mohammed AB, Baset AA. Vitamin C and asthma in children: modification ofthe effect by age, exposure to dampness and the severity of asthma. Clin Transl Allergy 2011; 1:9




DOI: http://dx.doi.org/10.29262/ram.v0i0.306

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