Resumen
Objetivo: Determinar la prevalencia y factores de riesgo de la enfermedad post-COVID-19 en una cohorte de niños y adolescentes de Puebla, México.
Métodos: Estudio de cohorte, observacional y analítico. Para el análisis estadístico se estimaron: porcentajes, frecuencias, promedios; razón de momios, prueba de χ2 y regresión logística binaria múltiple. Se utilizó el programa Statistical Package, for the Social Sciencies 23.
Resultados: La prevalencia de enfermedad post-COVID-19 fue de 14.8% de 175 pacientes que cumplieron con los criterios de inclusión, 26 padecieron la enfermedad post-COVID-19; la edad promedio fue de 5.9 años (DE: 5.05). La distribución por género fue: 27% hombres y 73% mujeres. Los síntomas más frecuentes fueron: fatiga, rinorrea, dolor muscular y disnea. Los síntomas asociados con enfermedad post-COVID-19 incluyeron: dolor muscular (OR: 27; p = 0.000; IC95%: 5.2-139), disgeusia (OR: 19; p = 0.012; IC95%: 1.9-19), fatiga (OR: 5; p = 0.001; IC95%: 1.9-13.5). Los factores riesgo asociados: mujer (OR: 3.58; p = 0.023; IC95%: 1.19-10.71), comorbilidades (OR: 24.5; p = 0.000; IC95%: 7.52-79), rinitis alérgica (OR: 8.7; p = 0.000; IC95%: 2.66-28.87) y dermatitis atópica (OR: 9.58; p = 0.016; IC95%: 1.51-60.5).
Conclusiones: Aunque la mayoría de los niños infectados por SARS-CoV-2 se recuperan por completo, algunos evolucionan a enfermedad post-COVID- 19. El conocimiento de los síntomas y factores de riesgo asociados con esta enfermedad permitirán una mejor evaluación, detección oportuna y tratamiento eficaz.
Referencias
-Yong SJ. Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments. Infect Dis 2021 ;53(10):737-754. doi: 10.1080/23744235.2021.1924397.
-Pazukhina E, Andreeva M, Spiridonova E, et al. Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID). BMC Med 2022 ;20(1):244. doi: 10.1186/s12916-022-02448-4.
-Stephenson T, Allin B, Nugawela MD, et al. Long COVID (post-COVID-19 condition) in children: a modified Delphi process. Arch Dis Child 2022 ;107(7):674-680. doi: 10.1136/archdischild-2021-323624.
-Izquierdo-Pujol J, Moron-Lopez S, Dalmau J, et al. Post COVID-19 Condition in Children and Adolescents: An Emerging Problem. Front Pediatr 2022 ;10:894204. doi: 10.3389/fped.2022.894204.
- Burki T. Clinical case definition of post-COVID-19 condition in children: a good start, but improvements are needed. Lancet Respir Med 2023 ;11(4):314. doi: 10.1016/S2213-2600(23)00081-4.
-Zimmermann P, Pittet LF, Curtis N. How Common is Long COVID in Children and Adolescents? Pediatr Infect Dis J 2021 ;40(12):e482-e487. doi: 10.1097/INF.0000000000003328.
-Pellegrino R, Chiappini E, Licari A, Galli L, Marseglia GL. Prevalence and clinical presentation of long COVID in children: a systematic review. Eur J Pediatr. 2022 ;181(12):3995-4009. doi: 10.1007/s00431-022-04600-x.
-Funk AL, Kuppermann N, Florin TA, et al. Post–COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection. JAMA Netw Open 2022;5(7):e2223253. doi:10.1001/jamanetworkopen.2022.23253
-Rao S, Lee GM, Razzaghi H, et al. Clinical Features and Burden of Postacute Sequelae of SARS-CoV-2 Infection in Children and Adolescents. JAMA Pediatr 2022;176(10):1000–1009. doi:10.1001/jamapediatrics.2022.2800
- WM A.World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects JAMA 2013; 310 (20): 2191-2194. doi:10.1001/jama.2013.281053
- Lopez-Leon S, Wegman-Ostrosky T, Ayuzo Del Valle NC, et al. Long-COVID in children and adolescents: a systematic review and meta-analyses. Sci Rep 2022 ;12(1):9950. doi: 10.1038/s41598-022-13495-5.
- Buonsenso D, Munblit D, De Rose C, et al. Preliminary evidence on long COVID in children. Acta Paediatr 2021 ;110(7):2208-2211. doi: 10.1111/apa.15870.
- Zimmermann P, Pittet LF, Curtis N. How Common is Long COVID in Children and Adolescents? Pediatr Infect Dis J 2021; 40(12):e482-e487. doi: 10.1097/INF.0000000000003328.
- Osmanov IM, Spiridonova E, Bobkova P, et al. Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study. Eur Respir J 2022 ;59(2):2101341. doi: 10.1183/13993003.01341-2021.
- Kikkenborg Berg S, Dam Nielsen S, Nygaard U, et al. Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study. Lancet Child Adolesc Health 2022;6(4):240-248. doi: 10.1016/S2352-4642(22)00004-9. (15)
- Kikkenborg Berg S, Palm P, Nygaard U, Bundgaard H, et al. A. Long COVID symptoms in SARS-CoV-2-positive children aged 0-14 years and matched controls in Denmark (LongCOVIDKidsDK): a national, cross-sectional study. Lancet Child Adolesc Health 2022 ;6(9):614-623. doi: 10.1016/S2352-4642(22)00154-7.
- Selvakumar J, Havdal LB, Drevvatne M, et al . Prevalence and Characteristics Associated With Post-COVID-19 Condition Among Nonhospitalized Adolescents and Young Adults. JAMA Netw Open 2023 ;6(3):e235763. doi: 10.1001/jamanetworkopen.2023.5763.
- Kikkenborg Berg S, Dam Nielsen S, Nygaard U, et al. Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study. Lancet Child Adolesc Health 2022 ;6(4):240-248. doi: 10.1016/S2352-4642(22)00004-9.
-Asadi-Pooya AA, Nemati H, Shahisavandi M, et al. Long COVID in children and adolescents. World J Pediatr 2021 Oct;17(5):495-499. doi: 10.1007/s12519-021-00457-6.
-Ludvigsson JF.Case report and systenmatic review suggest that children may experience similar long-term effects to adults after clinical COVID. Acta Paediatr 2021;110(3):914-921. doi:10.1111/apa.15673.
-Moreno-Pérez O, Merino E, Leon-Ramírez JM, et al. Post-acute COVID-19 Syndrome. Incidence and risk factors: a Mediterranean cohort study. J Infect 2021; 82(3):378-383. doi:10.1016/j.jinf.2021.01.004
-Munblit D, Greenhawt M, Brough HA, et al. Allergic diseases and immunodeficiencies in children, lessons learnt from COVID-19 pandemic by 2022: A statement from the EAACI-section on pediatrics. Pediatr Allergy Immunol 2022 ;33(10):e13851. doi: 10.1111/pai.13851.
-Crook H, Raza S, Nowell J, Young M, Edison P. Long covid:mecanismos factores de riesgo y manejo.BMJ 2021;374: n168
- Fainardi V, Meoli A, Chiopris G, et al. Long COVID in Children and Adolescents. Life (Basel) 2022 ;12(2):285. doi: 10.3390/life12020285.

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