Sueño y sistema inmune

Autores/as

DOI:

https://doi.org/10.29262/ram.v65i2.359

Palabras clave:

Sueño, Privación del sueño, Citocinas, Sistema inmune, Inflamación

Resumen

El sueño es un proceso que ocupa la tercera parte de la vida del ser humano y resulta imprescindible para que el individuo mantenga la homeostasis del organismo. Emerge como un regulador importante del sistema inmune, ya que durante el sueño se llevan a cabo las funciones necesarias para mantener su equilibrio. Por otro lado, la reducción de sueño tiene efectos adversos que alteran el metabolismo y produce incremento en la secreción de la proteína C reactiva, interleucina (IL)-6 y factor de necrosis tumoral (TNF). Estas citocinas activan a NF-κB, por lo que la alteración en el sueño puede ser un factor de riesgo para desarrollar enfermedades inflamatorias crónicas y metabólicas. Las citocinas proinflamatorias IL-1, IL-6 y TNF aumentan el sueño de movimientos oculares no rápidos y las antiinflamatorias como IL-4 e IL-10 lo disminuyen. El sueño puede modificar la función del sistema inmune induciendo cambios en el eje hipotálamo-pituitaria-adrenal y el sistema nervioso simpático. A su vez, el ritmo circadiano de hormonas como el cortisol y la adrenalina, que descienden en la noche, favorece diferentes actividades del sistema inmune. El objetivo de la presente revisión es abordar diversos aspectos del sueño y su relación con el sistema inmune.

Biografía del autor/a

María Guadalupe Rico-Rosillo, Universidad Nacional Autónoma de México, Facultad de Medicina, Unidad de Medicina Experimental, Ciudad de México

Dra. en C. Investigador Titular "B" en el IMSS hasta 2007 Técnico Académico Titular "C" en la UNAM 2009 a la fecha

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Publicado

2018-07-04

Cómo citar

Rico-Rosillo, M. G., & Vega-Robledo, G. B. (2018). Sueño y sistema inmune. Revista Alergia México, 65(2), 160-170. https://doi.org/10.29262/ram.v65i2.359

Número

Sección

Inmunología

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