Participación de los linfocitos B reguladores (Breg) en las enfermedades alérgicas
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Células B reguladoras
Interleucina-10
Tolerancia inmunológica
Respuesta inmune

Resumen

La tolerancia inmunológica, tanto a los antígenos exógenos como a los autoantígenos, es esencial para restringir las respuestas inflamatorias no deseadas que pudieran derivar en daño grave a los tejidos del organismo o provocar enfermedades crónicas. Durante las últimas décadas, diversas poblaciones celulares y moléculas secretadas por estas se han asociado con mecanismos supresores y reguladores de las respuestas inmunes. Aunque las células B adquieren relevancia típicamente como precursores de células productoras de anticuerpos, también son capaces desarrollar potentes funciones reguladoras a través de la producción de moléculas solubles o mediante el establecimiento de interacciones celulares directas mediadas por diferentes proteínas de superficie implicadas en transducción de señales. Si bien la mayoría de los estudios de células B reguladoras definen el papel de estos linfocitos en enfermedades autoinmunes, en años recientes se ha acumulado evidencia de su importancia y mecanismos de acción en enfermedades alérgicas. Las células reguladoras B parecen ser elementos relevantes en el establecimiento o pérdida de la tolerancia a alérgenos en diferentes enfermedades alérgicas, si bien aún han sido poco explorados.

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Referencias

Akdis CA, Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol. 2011;127(1):18-27. DOI: 10.1016/j.jaci.2010.11.030

Goodman WA, Cooper KD, McCormick TS. Regulation generation: the suppressive functions of human regulatory T cells. Crit Rev Immunol. 2012;32(1):65-79.

Harrison OJ, Powrie FM. Regulatory T cells and immune tolerance in the intestine. Cold Spring Harb Perspect Biol. 2013;5(7). DOI: 10.1101/cshperspect.a018341

Milojevic D, Nguyen KD, Wara D, Mellins ED. Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development. Pediatr Rheumatol Online J. 2008;6:20. DOI: 10.1186/1546-0096-6-20

Noval Rivas M, Chatila TA. Regulatory T cells in allergic diseases. J Allergy Clin Immunol. 2016;138(3):639-652. DOI: 10.1016/j.jaci.2016.06.003

Santos-Argumedo L. Phenotypic and functional diversity of B lymphocytes. Rev Alerg Mex. 2015;62(4):302-311.

Katz SI, Parker D, Turk JL. B-cell suppression of delayed hypersensitivity reactions. Nature. 1974;251(5475):550-551.

Neta R, Salvin SB. Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity. J Immunol. 1974;113(6):1716-1725.

Sabbele NR, Van-Oudenaren A, Benner R. The effect of cyclophosphamide on B cells and ‘background’ immunoglobulin-secreting cells in mice. Immunopharmacology. 1988;15(1):21-30.

O’Garra A, Stapleton G, Dhar V, Pearce M, Schumacher J, Rugo H, et al. Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10. Int Immunol. 1990;2(9):821-832.

Wolf SD, Dittel BN, Hardardottir F, Janeway CA. Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med. 1996;184(6):2271-2278. DOI: 10.1084/jem.184.6.2271

Mizoguchi A, Mizoguchi E, Takedatsu H, Blumberg RS, Bhan AK. Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation. Immunity. 2002;16(2):219-230. DOI: 10.1016/S1074-7613(02)00274-1

Fillatreau S, Sweenie CH, McGeachy MJ, Gray D, Anderton SM. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3(10):944-950.

Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med. 2003;197(4):489-501.

Van-De-Veen W, Stanic B, Wirz OF, Jansen K, Globinska A, Akdis M. Role of regulatory B cells in immune tolerance to allergens and beyond. J Allergy Clin Immunol. 2016;138(3):654-665. DOI: 10.1016/j.jaci.2016.07.006

Van-De-Veen W, Akdis M. Role of IgG4 in IgE-mediated allergic responses. J Allergy Clin Immunol. 2016;138(5):1434-1435. DOI: 10.1016/j.jaci.2016.07.022

Egwuagu CE, Yu CR. Interleukin 35-producing B cells (i35-Breg): a new mediator of regulatory B-cell functions in cns autoimmune diseases. Crit Rev Immunol. 2015;35(1):49-57.

Shen P, Roch T, Lampropoulou V, O’Connor RA, Stervbo U, Hilgenberg E, et al. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature. 2014;507(7492):366-370. DOI: 10.1038/nature12979

Blair PA, Noreña LY, Flores-Borja F, Rawlings DJ, Isenberg DA, Ehrenstein MR, et al. CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients. Immunity. 2010 Jan 29;32(1):129-140. DOI: 10.1016/j.immuni.2009.11.009

Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood. 2011;117(2):530-541. DOI: 10.1182/blood-2010-07-294249

Khan AR, Amu S, Saunders SP, Fallon PG. The generation of regulatory B cells by helminth parasites. Methods Mol Biol. 2014;1190:143-162. DOI: 10.1007/978-1-4939-1161-5_11

Klinker MW, Reed TJ, Fox DA, Lundy SK. Interleukin-5 supports the expansion of fas ligand-expressing killer B cells that induce antigen-specific apoptosis of CD4(+) T cells and secrete interleukin-10. PLoS One. 2013;8(8):e70131. DOI: 10.1371/journal.pone.0070131

Shalapour S, Font-Burgada J, Di-Caro G, Zhong Z, Sánchez-López E, Dhar D, et al. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 2015;521(7550):94-98. DOI: 10.1038/nature14395

Van-De-Veen W, Stanic B, Yaman G, Wawrzyniak M, Söllner S, Akdis DG, et al. IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. J Allergy Clin Immunol. 2013;131(4):1204-1212. DOI: 10.1016/j.jaci.2013.01.014

Maravillas-Montero JL, Acevedo-Ochoa E. Human B regulatory cells: the new players in autoimmune disease. Rev Invest Clin. 2017;69(5):243-246. DOI: 10.24875/RIC.17002266

Vidarsson G, Dekkers G, Rispens T. IgG subclasses and allotypes: from structure to effector functions. Front Immunol. 2014;5:520. DOI: 10.3389/fimmu.2014.00520

Van Der Neut Kolfschoten M, Schuurman J, Losen M, Bleeker WK, Martínez-Martínez P, Vermeulen E, et al. Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange. Science. 2007;317(5844):1554-1557. DOI: 10.1126/science.1144603

Aalberse RC, Platts-Mills TA, Rispens T. The developmental history of IgE and IgG4 antibodies in relation to atopy, eosinophilic esophagitis, and the modified TH2 response. Curr Allergy Asthma Rep. 2016;16(6):45. DOI: 10.1007/s11882-016-0621-x

O’Garra A, Chang R, Go N, Hastings R, Haughton G, Howard M. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol. 1992;22(3):711-717. DOI: 10.1002/eji.1830220314

Yanaba K, Bouaziz JD, Haas KM, Poe JC, Fujimoto M, Tedder TF.. A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. Immunity. 2008;28(5):639-650.

Gray M, Miles K, Salter D, Savill J. Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells. Proc Natl Acad Sci USA. 2007;104(35):14080-14085. DOI: 10.1073/pnas.0700326104

Evans JG, Chavez-Rueda KA, Eddaoudi A, Meyer-Bahlburg A, Rawlings DJ, Ehrenstein MR, et al. Novel suppressive function of transitional 2 B cells in experimental arthritis. J Immunol. 2007;178(12):7868-7878. DOI: 10.4049/jimmunol.178.12.7868

Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009;182(12):7459-7472. DOI: 10.4049/jimmunol.0900270

Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, et al. Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. Nature. 2012;491(7423):264-268. DOI: 10.1038/nature11501

Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Ther. 2013;15(Suppl 1):S1. DOI: 10.1186/ar3907

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, et al. Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells. Eur J Immunol. 2015;45(6):1842-1854. DOI: 10.1002/eji.201445211

Matsushita T, Le Huu D, Kobayashi T, Hamaguchi Y, Hasegawa M, Naka K, et al. A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation. J Allergy Clin Immunol. 2016;138(4):1170-1182. DOI: 10.1016/j.jaci.2015.12.1319

Menon M, Blair PA, Isenberg DA, Mauri C. A regulatory feedback between plasmacytoid dendritic cells and regulatory B cells is aberrant in systemic lupus erythematosus. Immunity. 2016;44(3):683-697. DOI: 10.1016/j.immuni.2016.02.012

Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004;118(2):229-241.DOI: 10.1016/j.cell.2004.07.002

Rosser EC, Oleinika K, Tonon S, Doyle R, Bosma A, Carter NA, et al. Regulatory B cells are induced by gut microbiota-driven interleukin-1beta and interleukin-1β production. Nat Med. 2014;20(11):1334-1339. DOI: 10.1038/nm.3680

Ho MH, Wong WH, Chang C. Clinical spectrum of food allergies: a comprehensive review. Clin Rev Allergy Immunol. 2014;46(3):225-240. DOI: 10.1007/s12016-012-8339-6

Manuyakorn W, Tanpowpong P. Cow milk protein allergy and other common food allergies and intolerances. Paediatr Int Child Health. 2018;17:1-9. DOI: 10.1080/20469047.2018.1490099

Sihra BS, Kon OM, Grant JA, Kay AB. Expression of high-affinity IgE receptors (Fc epsilon RI) on peripheral blood basophils, monocytes, and eosinophils in atopic and nonatopic subjects: relationship to total serum IgE concentrations. J Allergy Clin Immunol. 1997;99(5):699-706.

Lee JH, Noh J, Noh G, Choi WS, Cho S, Lee SS. Allergen-specific transforming growth factor-beta-producing CD19+CD5+ regulatory B-cell (Br3) responses in human late eczematous allergic reactions to cow’s milk. J Interferon Cytokine Res. 2011;31(5):441-449. DOI: 10.1089/jir.2010.0020

Noh G, Lee JH. Regulatory B cells and allergic diseases. Allergy Asthma Immunol Res. 2011;3(3):168-177. DOI: 10.4168/aair.2011.3.3.168

Noh J, Lee JH, Noh G, Bang SY, Kim HS, Choi WS, et al. Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in cow milk allergy. Cell Immunol. 2010;264(2):143-149. DOI: 10.1016/j.cellimm.2010.05.013

Lee JH, Noh G, Noh J, Lee S, Choi WS, Kim HS, et al. Clinical characteristics of oral tolerance induction of IgE-mediated and non-IgE-mediated food allergy using interferon gamma. Allergy Asthma Proc. 2010;31(4):e39-e47. DOI: 10.2500/aap.2010.31.3345

Noh G, Lee SS. A pilot study of interferon-gamma-induced specific oral tolerance induction (ISOTI) for immunoglobulin E-mediated anaphylactic food allergy. J Interferon Cytokine Res. 2009;29(10):667-675. DOI: 10.1089/jir.2009.0001

Noh J, Noh G, Lee SJ, Lee JH, Kim A, Kim HS, et al. Tolerogenic effects of interferon-gamma with induction of allergen-specific interleukin-10-producing regulatory B cell (Br1) changes in non-IgE-mediated food allergy. Cell Immunol. 2012;273(2):140-149. DOI: 10.1016/j.cellimm.2011.12.006

Lee SJ, Noh G, Lee JH. In vitro induction of allergen-specific interleukin-10-producing regulatory B cell responses by interferon-gamma in non-immunoglobulin E-mediated milk allergy. Allergy Asthma Immunol Res. 2013;5(1):48-54. DOI: 10.4168/aair.2013.5.1.48

Kim AR, Kim HS, Kim DK, Nam ST, Kim HW, Park YH, et al. Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow’s milk casein-induced allergic responses in mice. Sci Rep. 2016;6:19685. DOI: 10.1038/srep19685

Liu ZQ, Wu Y, Song JP, Liu X, Liu Z, Zheng PY, et al. Tolerogenic CX3CR1+ B cells suppress food allergy-induced intestinal inflammation in mice. Allergy. 2013;68(10):1241-1248. DOI: 10.1111/all.12218

McCracken JL, Veeranki SP, Ameredes BT, Calhoun WJ. Diagnosis and management of asthma in adults: a review. JAMA. 2017;318(3):279-290. DOI: 10.1001/jama.2017.8372

Hussaarts L, Van-Der-Vlugt LE, Yazdanbakhsh M, Smits HH. Regulatory B-cell induction by helminths: implications for allergic disease. J Allergy Clin Immunol. 2011;128(4):733-739. DOI: 10.1016/j.jaci.2011.05.012

Mauri C, Bosma A. Immune regulatory function of B cells. Annu Rev Immunol. 2012;30:221-241. DOI: 10.1146/annurev-immunol-020711-074934

Smits HH, Everts B, Hartgers FC, Yazdanbakhsh. Chronic helminth infections protect against allergic diseases by active regulatory processes. Curr Allergy Asthma Rep. 2010;10(1):3-12. DOI: 10.1007/s11882-009-0085-3

Braza F, Chesne J, Durand M, Dirou S, Mahay G, Magnan A, et al. A regulatory CD9(+) B-cell subset inhibits HDM-induced allergic airway inflammation. Allergy. 2015;70(11):1421-1431. DOI: 10.1111/all.12697

Reyes R, Cardeñes B, Machado-Pineda Y, Cabañas C. Tetraspanin CD9: a key regulator of cell adhesion in the immune system. Front Immunol. 2018;9:863. DOI: 10.3389/fimmu.2018.00863

Singh A, Carson WF, Secor ER, Guernsey LA, Flavell RA, Clark RB, et al. Regulatory role of B cells in a murine model of allergic airway disease. J Immunol. 2008;180(11):7318-7326.

Natarajan P, Singh A, McNamara JT, Secor ER, Guernsey LA, Thrall RS, et al. Regulatory B cells from hilar lymph nodes of tolerant mice in a murine model of allergic airway disease are CD5+, express TGF-beta, and co-localize with CD4+Foxp3+ T cells. Mucosal Immunol. 2012;5(6):691-701. DOI: 10.1038/mi.2012.42

Van Der Vlugt LE, Mlejnek E, Ozir-Fazalalikhan A, Janssen Bonas M, Dijksman TR, Labuda LA, et al. CD24(hi)CD27(+) B cells from patients with allergic asthma have impaired regulatory activity in response to lipopolysaccharide. Clin Exp Allergy. 2014;44(4):517-528. DOI: 10.1111/cea.12238

Blaiss MS, Hammerby E, Robinson S, Kennedy-Martin T, Buchs S. The burden of allergic rhinitis and allergic rhinoconjunctivitis on adolescents: a literature review. Ann Allergy Asthma Immunol. 2018;121(1):43-52. DOI: 10.1016/j.anai.2018.03.028

Kim AS, Doherty TA, Karta MR, Das S, Baum R, Beppu A, et al. Regulatory B cells and T follicular helper cells are reduced in allergic rhinitis. J Allergy Clin Immunol. 2016;138(4):1192-1195. DOI: 10.1016/j.jaci.2016.03.017

Fonacier LS, Dreskin SC, Leung DY. Allergic skin diseases. J Allergy Clin Immunol. 2010;125(2 Suppl 2):S138-S149. DOI: 10.1016/j.jaci.2009.05.039

Jin G, Hamaguchi Y, Matsushita T, Hasegawa M, Le Huu D, Ishiura N, et al. B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells. J Allergy Clin Immunol. 2013;131(6):1674-1682. DOI: 10.1016/j.jaci.2013.01.044

Mazer B. Is there a place for B cells as regulators of immune tolerance in allergic diseases? Clin Exp Allergy. 2014;44(4):469-471. DOI: 10.1111/cea.12274

Watanabe R, Fujimoto M, Ishiura N, Kuwano Y, Nakashima H, Yazawa N, et al. CD19 expression in B cells is important for suppression of contact hypersensitivity. Am J Pathol. 2007;171(2):560-570. DOI: 10.2353/ajpath.2007.061279

Vitale G, Mion F, Pucillo C. Regulatory B cells: evidence, developmental origin and population diversity. Mol Immunol. 2010;48(1-3):1-8. DOI: 10.1016/j.molimm.2010.09.010

Falcó SN, Ferré Ybarz L. Hipersensibilidad a veneno de himenópteros. España: Asociación Española de Pediatría. 2013;1:135-144.

Boonpiyathad T, Meyer N, Moniuszko M, Sokolowska M, Eljaszewicz A, Wirz OF, et al. High-dose bee venom exposure induces similar tolerogenic B-cell responses in allergic patients and healthy beekeepers. Allergy. 2017;72(3):407-415. DOI: 10.1111/all.12966

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