Participación de los linfocitos B reguladores (Breg) en las enfermedades alérgicas.

Itze Cecilia Navarro Hernandez, Rodrigo Cervantes Díaz, Sandra Romero Ramírez, Víctor Andrés Sosa Hernández, Ari Kleinberg Bild, David Meza Sánchez, José Luis Maravillas Montero

Resumen


El papel de la tolerancia inmunológica, tanto a los antígenos exógenos como a los autoantígenos, es esencial para restringir las respuestas inflamatorias no deseadas que podrían derivar en daño grave a los tejidos del organismo o provocar enfermedades crónicas. Durante las últimas décadas, diversas poblaciones celulares y moléculas secretadas por estas mismas, se han asociado con mecanismos supresores y reguladores de las respuestas inmunes. Aunque las células B adquieren relevancia típicamente como precursores de células productoras de anticuerpos, también son capaces desarrollar potentes funciones reguladoras a través de la producción de moléculas solubles o mediante el establecimiento de interacciones celulares directas mediadas por diferentes proteínas superficie implicadas en transducción de señales. Si bien la mayoría de los estudios de células B reguladoras definen el papel de estos linfocitos en enfermedades autoinmunes, en años recientes se han ido acumulando evidencias de su importancia y mecanismos de acción en enfermedades alérgicas. Como resultado, las células reguladoras B parecen ser elementos muy importantes pero aún poco explorados, en el establecimiento o pérdida de la tolerancia a alérgenos en diferentes enfermedades alérgicas.


Palabras clave


células B reguladoras; alergia; IL-10; tolerancia; supresión

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DOI: http://dx.doi.org/10.29262/ram.v65i1.529

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