Palabras clave
profilinas
proteínas trasportadoras de lípidos
Cómo citar
Plaudit
Resumen
El síndrome polen-alimento (SPA) se caracteriza por la sensibilización alérgica a proteínas de pólenes de pastos, malezas y árboles, que producen una reacción de hipersensibilidad de tipo I, asociada a la ingesta de alimentos derivados de plantas, usualmente en forma cruda. Las familias de proteínas que más frecuentemente están asociadas son las profilinas, las PR-10 y las ns LTP; sin embargo, se ha documentado otras, como las taumatinas, isoflavonas reductasas y las B1,2 gluconasas. El síndrome prototipo es el abedul-frutas-vegetales, y de ellos el más común es el abedul-manzana, debido a que más de 70 % de los pacientes sensibilizados al abedul presentan síntomas asociados a la ingesta de alimentos derivados de plantas. Los síntomas están restringidos a la cavidad oral; sin embargo, algunos pacientes pueden presentar síntomas sistémicos, incluso anafilaxia, por lo que es importante identificar el tipo de proteína implicada, ya que de eso depende el tipo de reacción que puede presentar el paciente. Pese a todo, se considera una entidad que puede estar subdiagnosticada debido a su valoración y tratamiento complejos, debido a que el procedimiento en la mayor parte de los casos es dieta de eliminación, ya que aún no está disponible el tratamiento con inmunoterapia. El objetivo de esta revisión es describir la fisiopatología, así como los síndromes polen-alimento más comunes.
Referencias
Carlson G, Coop C. Pollen food allergy syndrome (PFAS): a review of current available literature. Ann Allergy Asthma Immunol. 2019;123:359-65. DOI: 10.1016/j.anai.2019.07.022
Guvenir H, Dibek E, Buyuktiryaki B, Zabun M, Capanoglu M, Toyran M, et al. Frequency and clinical features of pollen-food syndrome in children. Allergol Immunopathol (Madr). 2020;48(1):78-83. DOI: 10.1016/j.aller.2019.07.010
Kiguchi T, Yamamoto-Hanada K, Saito-Abe M, Sato M, Irahara M, Ogita H, et al. Pollen-food allergy syndrome and component sensitization in adolescents: a Japanese population-based study. PLos ONE. 2021;16(4):e0249649. DOI: 10.1371/journal.pone.0249649
Poncet P, Sénéchal H, Charpin D. Update on pollen-food allergy syndrome. Expert Rev Clin Immunol. 2020;16(6):561-78. DOI: 10.1080/1744666X.2020.1774366
Popescu FD. Cross-reactivity between aeroallergens and food allergens. World J Methodol. 2015;5(2):31-50. DOI: 10.5662/wjm.v5.i2.31
Sánchez-López J, Asturias JA, Enrique E, Suárez-Cervera M, Bartra J. Cupressus arizonica pollen: a new pollen involved in the lipid transfer protein syndrome?. J Investig Allergol Clin Immunol. 2011;21(7):522-6. Disponible en: http://www.jiaci.org/issues/vol21issue7/vol21issue07-4.htm
Yagami A, Nakazawa Y, Suzuki K, Matsunaga K. Curry spice allergy associated with pollen-food allergy syndrome and latex fruit-syndrome. J Dermatol. 2009;36(1): 45-9. DOI: 10.1111/j.1346-8138.2008.00584.x
Fernández Rivas, M. Reactividad cruzada en frutas y vegetales [Cross-reactivity between fruit and vegetables]. Allergol Immunopathol (Madr). 2003;31(3):141-6. DOI: 10.1016/s0301-0546(03)79281-7
Pauli G, Metz-Favre C. Allergies croisées pollens-aliments [Cross reactions between pollens and vegetable food allergens]. Rev Mal Respir. 2013;30(4):328-37. DOI: 10.1016/j.rmr.2012.10.633
Azofra J, Berroa F, Gastaminza G, Saiz N, Gamboa PM, Vela C, et al. Lipid transfer protein syndrome in a non-mediterranean Area. Int Arch Allergy Immunol. 2016;169(3):181-8. DOI: 10.1159/000445893
Ausukua M, Dublin I, Echebarria MA, Aguirre JM. Oral Allergy Syndrome (OAS). General and stomatological aspects. Med Oral Patol Oral Cir Bucal. 200914(11); e568-72. DOI: 10.4317/medoral.14.e568. PMID: 19680197
Mari A, Ballmer-Weber BK, Vieths S. The oral allergy syndrome: improved diagnostic and treatment methods. Curr Opin Allergy Clin Immunol. 2005;5(3):267-73. DOI: 10.1097/01.all.0000168793.27948.b0
Incorvaia C, Ridolo E, Mauro M, Russello M, Pastorello E. Allergen immunotherapy for birch-apple syndrome: what do we know? Immunotherapy 2017;9(15):1271-8. DOI: 10.2217/imt-2017-0040
Sano A, Yagami A, Inaba Y, Yamakita T, Suzuki K, Matsunaga K. Sensitization profiles of a case of pollen-food allergy syndrome. Allergol Int. 2011;60(1):97-101. DOI: 10.2332/allergolint.10-CR-0235
Skypala IJ. Can patients with oral allergy syndrome be at risk of anaphylaxis?. Curr Opin Allergy Clin Immunol. 2020;20(5):459-64. DOI: 10.1097/ACI.0000000000000679
Gomes-Belo J, Hannachi F, Swan K, Santos AF. Advances in food allergy diagnosis. Curr Pediatr Rev. 2018;14(3):139-49. DOI: 10.2174/1573396314666180423105842
Wawrzeńczyk A, Żbikowska-Gotz M, Wawrzeńczyk A, Bartuzi Z. Sensitisation to lipid transfer proteins in pollen - allergic adults with food allergy. Postepy Dermatol Alergol. 2020;37(4): 508-12. DOI: 10.5114/ada.2020.98278
Ma S, Sicherer SH, Nowak-Wegrzyn A. A survey on the management of pollen-food allergy syndrome in allergy practices. J Allergy Clin Immunol. 2003;112(4):784-8. DOI:10.1016/s0091-6749(03)02008-6
Asero R, Pravettoni V. Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome. Curr Opin Allergy Clin Immunol. 2013;13(4):379-85. DOI: 10.1097/ACI.0b013e32835f5b07
Deschildre A, Lejeune S. How to cope with food allergy symptoms? Curr Opin Allergy Clin Immunol. 2018;18(3):234-42. DOI:10.1097/aci.0000000000000447
Lipp T, Acar Şahin A, Aggelidis X, Arasi S, Barbalace A, Bourgoin A, et al. Heterogeneity of pollen food allergy syndrome in seven Southern European countries: The @IT.2020 multicenter study. Allergy. 2021; 76(10):3041-52. DOI: 10.1111/all.14742
Kinaciyan T, Jahn-Schmid B, Radakovics A, Zwölfer B, Schreiber C, Francis JN, et al. Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1. J Allergy Clin Immunol. 2007;119(4):937-43 DOI: 10.1016/j.jaci.2006.11.010.
Yamamoto T, Asakura K, Shirasaki H, Himi T. [Relationship between IgE antibodies to recombinant allergens rBet v 1 and rBet v 2 and food causing oral allergy syndrome in cases of birch-pollen allergy]. Nihon Jibiinkoka Gakkai Kaiho. 2010;113(8):661-9. DOI: 10.3950/jibiinkoka.113.661
Mauro M, Russello M, Incorvaia C, Gazzola G, Frati F, Moingeon P, et al. Birch-apple syndrome treated with birch pollen immunotherapy. Int Arch Allergy Immunol. 2011;156(4):416-42. DOI: 10.1159/000323909
Santos A, Van Ree R. Profilins: mimickers of allergy or relevant allergens?. Int Arch Allergy Immunol. 2011;155(3):191-204. DOI: 10.1159/000321178
Ebisawa M, Ballmer-Weber BK, Vieths S, Wood RA (editores). Food allergy: molecular basis and clinical practice. Karger Medical and Scientific Publishers; 2015. p. 162-170.
Rial MJ, Sastre J. Food allergies caused by allergenic lipid transfer proteins: what is behind the geographic restriction?. Curr Allergy Asthma Rep. 2018;18(11):56. DOI: 10.1007/s11882-018-0810-x
Walter G, Kalicinsky C. Adult-onset IgE-mediated food allergy at a Winnipeg allergy clinic: a case series. Allergy Asthma Clin Immunol. 2020;16:85. DOI: 10.1186/s13223-020-00483-5
Asero R. Fennel, cucumber, and melon allergy successfully treated with pollen-specific injection immunotherapy. Ann Allergy Asthma Immunol. 2000;84(4):460-2. DOI: 10.1016/S1081-1206(10)62281-8
Cudowska B, Kaczmarski M, Restani P. Lipid transfer protein in diagnosis of birch-apple syndrome in children. Immunobiology. 2008;213(2):89-96. DOI: 10.1016/j.imbio.2007.07.006
Konstantinou GN, Grattan CE. Food contact hypersensitivity syndrome: the mucosal contact urticaria paradigm. Clin Exp Dermatol. 2008;33(4):383-9. DOI: 10.1111/j.1365-2230.2008.02893.x
Ortolani C, Ispano M, Pastorello EA, Ansaloni R, Magri GC. Comparison of results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol. 1989;83(3):683-90. DOI: 10.1016/0091-6749(89)90083-3
Maeda N, Inomata N, Morita A, Kirino M, Ikezawa Z. Correlation of oral allergy syndrome due to plant-derived foods with pollen sensitization in Japan. Ann Allergy Asthma Immunol. 2010;104(3):205-10. DOI: 10.1016/j.anai.2009.11.049
Cuesta-Herranz J, Lázaro M, de las Heras M, Lluch M, Figueredo E, Umpierrez A, et al. Peach allergy pattern: experience in 70 patients. Allergy. 1998;53(1):78-82. DOI: 10.1111/j.1398-9995.1998.tb03777.x
Tavares B, Machado D, Loureiro G, Cemlyn-Jones J, Pereira C. Sensitization to profilin in the central region of Portugal. Sci Total Environ. 2008 15;407(1):273-8. DOI: 10.1016/j.scitotenv.2008.08.013
Barre A, Culerrier R, Granier C, Selman L, Peumans WJ, Van Damme EJ, et al. Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3 beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome. Mol Immunol. 2009;46(8-9):1595-604. DOI: 10.1016/j.molimm.2008.12.007.
Wagner A, Szwed A, Buczyłko K, Wagner W. Allergy to apple cultivars among patients with birch pollinosis and oral allergy syndrome. Ann Allergy Asthma Immunol. 2016;117(4):399-404. DOI: 10.1016/j.anai.2016.08.015
Gabrielli S, Clarke AE, Morris J, Gravel J, Lim R, Chan ES, et al. Fruit-induced anaphylaxis: clinical presentation and Management. J allergy Clin Immunol Pract. 2021;9(7):2825-30.e2. DOI: 10.1016/j.jaip.2021.02.055
Inomata N, Miyakawa M, Aihara M. Eyelid edema as a predictive factor for sensitization to Pru p 7 in peach allergy. J Dermatol. 2016;43(8):900-5. DOI: 10.1111/1346-8138.13316
Yagami A, Ebisawa M. New findings, pathophysiology, and antigen analysis in pollen-food allergy syndrome. Curr Opin Allergy Clin Immunol. 2019;19(3):218-23. DOI: 10.1097/ACI.0000000000000533
Muluk NB, Cingi C. Oral allergy syndrome. Am J Rhinol Allergy. 2018 1;32(1):27-30. DOI: 10.2500/ajra.2018.32.4489
Hofmann A, Burks AW. Pollen food syndrome: update on the allergens. Curr Allergy Asthma Rep. 2008;8(5):413-7. doi: 10.1007/s11882-008-0080-0
Kim JH. Insights into pediatric pollen food allergy syndrome. Clin Exp Pediatr. 2020;63(12):483-84. DOI: 10.3345/cep.2019.01179.
Jeon YH. Pollen-food allergy syndrome in children. Clin Exp Pediatr. 2020;63(12):463-68. DOI: 10.3345/cep.2019.00780
Price A, Ramachandran S, Smith GP, Stevenson ML, Pomeranz MK, Cohen DE. Oral allergy syndrome (pollen-food allergy syndrome). Dermatitis. 2015;26(2):78-88. DOI: 10.1097/DER.0000000000000087
Brown CE, Katelaris CH. The prevalence of the oral allergy syndrome and pollen-food syndrome in an atopic paediatric population in south-west Sydney. J Paediatr Child Health. 2014;50(10):795-800. DOI: 10.1111/jpc.12658
Geroldinger-Simic M, Zelniker T, Aberer W, Ebner C, Egger C, Greiderer A, Birch pollen-related food allergy: clinical aspects and the role of allergen-specific IgE and IgG4 antibodies. J Allergy Clin Immunol. 2011;127(3):616-22.e1. DOI: 10.1016/j.jaci.2010.10.027
Kondo Y, Urisu A. Oral allergy syndrome. Allergol Int. 2009;58(4):485-91. DOI: 10.2332/allergolint.09-RAI-0136.
Bohle B. The impact of pollen-related food allergens on pollen allergy. Allergy. 2007;62(1):3-10. DOI: 10.1111/j.1398-9995.2006.01258
Osawa Y, Ito Y, Takahashi N, Sugimoto C, Kohno Y, Mori S, et al. Epidemiological study of oral allergy syndrome in birch pollen dispersal-free regions. Allergol Int. 2020;69(2):246-52. DOI: 10.1016/j.alit.2019.09.008
Kim JH, Kim SH, Park HW, Cho SH, Chang YS. Oral allergy syndrome in birch pollen-sensitized patients from a Korean University Hospital. J Korean Med Sci. 2018;13;33(33):e218. DOI: 10.3346/jkms.2018.33.e218
Deng S, Yin J. Mugwort pollen-related food allergy: lipid transfer protein sensitization and correlation with the severity of allergic reactions in a Chinese population. Allergy Asthma Immunol Res. 2019;11(1):116-28. DOI: 10.4168/aair.2019.11.1.116
Ma S, Yin J. Imbalance of serum IL-10 and TGF-in patients with pollen food syndrome. Allergol Immunopathol (Madr). 2014;42(3):198-205. DOI: 10.1016/j.aller.2013.01.004.
Mastrorilli C, Tripodi S, Caffarelli C, Perna S, Rienzo-Businco A, Sfika I, et al. Endotypes of pollen-food syndrome in children with seasonal allergic rhinoconjunctivitis: a molecular classification. Allergy. 2016;71(8):1181-91. DOI: 10.1111/all.12888
Egger M, Mutschlechner S, Wopfner N, Gadermaier G, Briza P, Ferreira F. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy. 2006;61(4):461-76. DOI: 10.1111/j.1398-9995.2006.00994.x
Katelaris C. Should patients with pollen fruit syndrome be prescribed an automatic epinephrine injector?. Curr Opin Allergy Clin Immunol. 2016;16(4):370-4. DOI: 10.1097/ACI.0000000000000278
Scurlock A. Oral and sublingual immunotherapy for treatment of IgE-Mediated food allergy. Clinic Rev Allerg Immunol. 2018;55(2):139-52. DOI: 10.1007/s12016-018-8677-0
Kim M, Ahn Y, Yoo Y, Kim D, Yang H, Park H, et al. Clinical manifestations and risk factors of anaphylaxis in pollen-food allergy syndrome. Yonsei Med J. 2019;60(10):960-68. DOI: 10.3349/ymj.2019.60.10.960
Li JD, Du ZR, Liu J, Xu YY, Wang RQ, Yin J. Characteristics of pollen-related food allergy based on individual pollen allergy profiles in the Chinese population. World Allergy Organ J. 2020;13(5):100120. DOI: 10.1016/j.waojou.2020.100120
Yagami T. Allergies to cross-reactive plant proteins. Latex-fruit syndrome is comparable with pollen-food allergy syndrome. Int Arch Allergy Immunol. 2002;128(4):271-79. DOI: 10.1159/000063859
Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.
Derechos de autor 2022 Revista Alergia México