Archivos suplementarios
Palabras clave
inmunodeficiencia secundaria
inmunocompetentes
tratamientos inmunomoduladores
Resumen
Las inmunodeficiencias secundarias aparecen en individuos previamente inmunocompetentes. La falta de respuesta primaria o secundaria a un antígeno extraño, en el caso de infecciones, es un dato centinela en el diagnóstico de inmunodeficiencia (puede ser primaria o secundaria); en el caso de un antígeno propio podría generar cáncer. Éste ha mostrado un aumento en la prevalencia e incidencia en forma global. La mayor parte de los tratamientos médicos actuales en cáncer se enfocan, fundamentalmente, a acciones inmunomoduladoras (inmunosupresióninmunoestimulación o ambos). El conocimiento de los conceptos clave, desde la perspectiva de la inmunidad innata y adquirida, conduce al desarrollo de cáncer, involucrándose a la vigilancia inmunológica y los mecanismos de escape de ésta, que contribuyen a comprender mejor el origen, comportamiento y tratamiento de las neoplasias. Los tratamientos pueden originar alteraciones inmunológicas como: alergia, anafilaxia, falta de respuesta por inmunogenicidad, campos de atención del especialista en Alergia e Inmunología clínica.
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