Angioedema

Autores/as

  • Luisa María Holguín-Gómez Universidad de Antioquia, Medellín, Antioquia
  • Luz Adriana Vásquez-Ochoa Hospital Pablo Tobón Uribe, Sección de Dermatología, Medellín, Antioquia
  • Ricardo Cardona Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín

DOI:

https://doi.org/10.29262/ram.v63i4.220

Palabras clave:

Angioedema, Histamina, Bradiquininas, Angioedema idiopático, Urticaria, Antiinflamatorios no esteroideos, Ciclooxigenasa

Resumen

El angioedema se define como el edema de piel o mucosas, incluidas las de los tractos respiratorio y gastrointestinal, de carácter autolimitado, que en la mayoría de los casos se resuelve en forma completa en menos de 72 horas. Ocurre por aumento de la permeabilidad de los capilares mucosos, submucosos y vénulas poscapilares, con la consiguiente extravasación del plasma. Existen diferentes tipos de angioedema: el histaminérgico (que puede ser mediado o no por inmunoglobulina E), el hereditario, por déficit de C1 inhibidor adquirido, por inhibidores de la enzima convertidora de la angiotensina, mediados por bradiquininas y el angioedema no histaminérgico idiopático. El tratamiento depende de la causa del angioedema, la edad, frecuencia y gravedad de sus manifestaciones. Las principales medidas son evitar los desencadenantes o disparadores externos, la administración de antihistamínicos, esteroides o adrenalina en el angioedema histaminérgico; el reemplazo de la proteína deficiente o el bloqueo de la acción de la bradiquinina en el déficit de C1 inhibidor y en el angioedema por inhibidores de la enzima convertidora de la angiotensina. 

Biografía del autor/a

Luisa María Holguín-Gómez, Universidad de Antioquia, Medellín, Antioquia

Médica General Fundación Universitaria San Martín Sabaneta, Antioquia. 

Residente de Alergología Clínica, Universidad de Antioquia, Colombia.

Luz Adriana Vásquez-Ochoa, Hospital Pablo Tobón Uribe, Sección de Dermatología, Medellín, Antioquia

Médica general Universidad Pontificia Bolivariana

Especialista en Dermatología Universidad Pontificia Bolivariana

Jefe Sección Dermatología Hospital Pablo Tobón Uribe

Ricardo Cardona, Universidad de Antioquia, Grupo de Alergología Clínica y Experimental, Medellín

Médico general Universidad de Antioquia

Especialista en Alergología e Inmunología Universidad de Antioquia

Jefe de Posgrado de Alergología Clínica Universidad de Antioquia

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Publicado

2016-10-30

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