Guía de dermatitis atópica. Consenso de la Sociedad Latinoamericana de Alergia, Asma e Inmunología
PubMed (Inglés)

Palabras clave

aeroalergeno
atopia
calentamiento global
sensibilización al polen
exacerbación de asma

Resumen

As in other regions, the incidence of atopic dermatitis in Latin America has been increasing in recent years. Although there are several clinical guidelines, many of their recommendations cannot be universal since they depend on the characteristics of each region. Thus, we decided to create a consensus guideline on atopic dermatitis applicable in Latin America and other tropical regions, taking into account socio-economic, geographical, cultural and health care system characteristics. The Latin American Society of Allergy Asthma and Immunology (SLAAI) conducted a systematic search for articles related to the pathophysiology, diagnosis and treatment of dermatitis using various electronic resources such as Google, Pubmed, EMBASE (Ovid) and Cochrane data base. We have also looked for all published articles in Latin America on the subject using LILACS (Latin American and Caribbean Literature on Health Sciences) database. Each section was reviewed by at least two members of the committee, and the final version was subsequently approved by all of them, using the Delphi methodology for consensus building. Afterward, the final document was shared for external evaluation with physicians, specialists (allergists, dermatologists and pediatricians), patients and academic institutions such as universities and scientific societies related to the topic. All recommendations made by these groups were taken into account for the final drafting of the document. There are few original studies conducted in Latin America about dermatitis; however, we were able to create a practical guideline for Latin America taking into account the particularities of the region. Moreover, the integral management was highlighted including many of the recommendations from different participants in the health care of this disease (patients, families, primary care physicians and specialists). This practical guide presents a concise approach to the diagnosis and management of atopic dermatitis that can be helpful for medical staff, patients and their families in Latin America.

PubMed (Inglés)

Referencias

Johansson SG, Bieber T, Dahl R, Friedmann PS, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol 2004;113:832-836.


Schäfer T, Krämer U, Vieluf D, Abeck D, et al. The excess of atopic eczema in East Germany is related to the intrinsic type. Br J Dermatol 2000;143:992-998.


Böhme M, Wickman M, Lennart Nordvall S, Svartengren M, Wahlgren CF. Family history and risk of atopic dermatitis in children up to 4 years. Clin Exp Allergy 2003;33:1226-1231.


Schmid-Grendelmeier P, Flückiger S, Disch R, Trautmann A, et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunol 2005;115:1068-1075.


Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI, Group IPTS. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol 2009;124(6):1251-1258.


Grize L, Gassner M, Wüthrich B, Bringolf-Isler B, et al. Trends in prevalence of asthma, allergic rhinitis and atopic dermatitis in 5-7-year old Swiss children from 1992 to 2001. Allergy 2006;61:556-562.


Weber AS, Haidinger G. The prevalence of atopic dermatitis in children is influenced by their parents’ education: results of two cross-sectional studies conducted in Upper Austria. Pediatr Allergy Immunol 2010;21:1028-1035.


Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol 2010;105:99-106.


Williams HC. Is the prevalence of atopic dermatitis increasing? Clin Exp Dermatol 1992;17:385-391.


Barnetson RS, Rogers M. Childhood atopic eczema. BMJ 2002;324:1376-1379.


Gustafsson D, Sjöberg O, Foucard T. Development of allergies and asthma in infants and young children with atopic dermatitis--a prospective follow-up to 7 years of age. Allergy 2000;55:240-245.


Kemp AS. Cost of illness of atopic dermatitis in children: a societal perspective. Pharmacoeconomics 2003;21:105- 113.


Lapidus CS, Schwarz DF, Honig PJ. Atopic dermatitis in children: who cares? Who pays? J Am Acad Dermatol 1993;28:699-703.


Lawson V, Lewis-Jones MS, Finlay AY, Reid P, Owens RG. The family impact of childhood atopic dermatitis: the Dermatitis Family Impact Questionnaire. Br J Dermatol 1998;138:107-113.


DaVeiga SP. Epidemiology of atopic dermatitis: a review. Allergy Asthma Proc 2012;33:227-234.


Williams HC. Diagnostic criteria for atopic dermatitis: where do we go from here? Arch Dermatol 1999;135:583-586.


Solé D, Mallol J, Wandalsen GF, Aguirre V, Group LAIPS. Prevalence of symptoms of eczema in Latin America: results of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3. J Investig Allergol Clin Immunol 2010;20:311-323.


Lugović L, Lipozencić J, Jakić-Razumović J. Prominent involvement of activated Th1-subset of T-cells and increased expression of receptor for IFN-gamma on keratinocytes in atopic dermatitis acute skin lesions. Int Arch Allergy Immunol 2005;137:125-133.


Segat L, Guimarães RL, Brandão LA, Rocha CR, et al. Beta defensin-1 gene (DEFB1) polymorphisms are not associated with atopic dermatitis in children and adolescents from northeast Brazil (Recife, Pernambuco). Int J Dermatol 2010;49:653-657.


Tamura K, Suzuki M, Arakawa H, Tokuyama K, Morikawa A. Linkage and association studies of STAT6 gene polymorphisms and allergic diseases. Int Arch Allergy Immunol 2003;131:33-38.


Novak N, Kruse S, Kraft S, Geiger E, et al. Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. J Invest Dermatol 2002;119:870-875.


Weidinger S, Klopp N, Wagenpfeil S, Rümmler L, et al. Association of a STAT 6 haplotype with elevated serum IgE levels in a population based cohort of white adults. J Med Genet 2004;41:658-663.


McAleer MA, Irvine AD. The multifunctional role of filaggrin in allergic skin disease. J Allergy Clin Immunol 2013;131:280-291.


Van den Oord RA, Sheikh A. Filaggrin gene defects and risk of developing allergic sensitisation and allergic disorders: systematic review and meta-analysis. BMJ 2009;339:2433.


Madva EN, Granstein RD. Nerve-derived transmitters including peptides influence cutaneous immunology. Brain Behav Immun 2013.


Sator PG, Schmidt JB, Hönigsmann H. Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 2003;48:352-358.


Wong CK, Leung KM, Qiu HN, Chow JY, et al. Activation of eosinophils interacting with dermal fibroblasts by pruritogenic cytokine IL-31 and alarmin IL-33: implications in atopic dermatitis. PLoS One 2012;7:29815.


Sayama K, Komatsuzawa H, Yamasaki K, Shirakata Y, et al. New mechanisms of skin innate immunity: ASK1-mediated keratinocyte differentiation regulates the expression of beta- defensins, LL37, and TLR2. Eur J Immunol 2005;35:1886- 1895.


Lee HW, Kim SM, Kim JM, Oh BM, et al. Potential immunoinflammatory role of staphylococcal enterotoxin a in atopic dermatitis: Immunohistopathological analysis and in vitro assay. Ann Dermatol 2013;25:173-180.


Gros E, Novak N. Cutaneous dendritic cells in allergic inflammation. Clin Exp Allergy 2012;42:1161-1175.


Nakajima S, Igyártó BZ, Honda T, Egawa G, et al. Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling. J Allergy Clin Immunol 2012;129:1048-1055.


Hijnen D, Knol EF, Gent YY, Giovannone B, et al. CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-γ, IL-13, IL-17, and IL-22. J Invest Dermatol 2013;133:973-979.


Stott B, Lavender P, Lehmann S, Pennino D, et al. Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation. J Allergy Clin Immunol 2013;132:446-454.


Matsuoka K, Shitara H, Taya C, Kohno K, et al. Novel basophil- or eosinophil-depleted mouse models for functional analyses of allergic inflammation. PLoS One 2013;8:60958.


Szalai K, Kopp T, Lukschal A, Stremnitzer C, et al. Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice. Exp Dermatol 2012;21:842-846.


Shen CY, Lin MC, Lin HK, Lin CH, et al. The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study. Allergy Asthma Proc 2013;34:78-83.


Valenta R, Duchêne M, Pettenburger K, Sillaber C, et al. Identification of profilin as a novel pollen allergen; IgE autoreactivity in sensitized individuals. Science 1991;253:557-560.


Mothes N, Niggemann B, Jenneck C, Hagemann T, et al. The cradle of IgE autoreactivity in atopic eczema lies in early infancy. J Allergy Clin Immunol 2005;116:706-709.


Bleiker TO, Shahidullah H, Dutton E, Graham-Brown RA. The prevalence and incidence of atopic dermatitis in a birth cohort: the importance of a family history of atopy. Arch Dermatol 2000;136:274.


Matsuoka S, Nakagawa R, Nakayama H, Yamashita K, Kuroda Y. Prevalence of specific allergic diseases in school children as related to parental atopy. Pediatr Int 1999;41:46-51.


Von Mutius E. The environmental predictors of allergic disease. J Allergy Clin Immunol 2000;105:9-19.


Acevedo N, Sánchez J, Zakzuk J, Bornacelly A, et al. Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study. BMC Pulm Med 2012;12:13.


Dei-Cas I, Dei-Cas P, Acuña K. Atopic dermatitis and risk factors in poor children from Great Buenos Aires, Argentina. Clin Exp Dermatol 2009;34:299-303.


Barreto ML, Teixeira MG, Bastos FI, Ximenes RA. Successes and failures in the control of infectious diseases in Brazil: social and environmental context, policies, interventions, and research needs. Lancet 2011;377:1877-1889.


Figueiredo CA, Amorim LD, Alcantara-Neves NM, Matos SM, et al. Environmental conditions, immunologic phenotypes, atopy, and asthma: new evidence of how the hygiene hypothesis operates in Latin America. J Allergy Clin Immunol 2013;131:1064-1068.


Alcantara-Neves NM, Veiga RV, Dattoli VC, Fiaccone RL, et al. The effect of single and multiple infections on atopy and wheezing in children. J Allergy Clin Immunol 2012;129:359-567.


Figueiredo CA, Alcantara-Neves NM, Amorim LD, Silva NB, et al. Evidence for a modulatory effect of IL-10 on both Th1 and Th2 cytokine production: the role of the environment. Clin Immunol 2011;139:57-64.


Hanifin JM. Diagnostic criteria for atopic dermatitis: consider the context. Arch Dermatol 1999;135:1551.


Williams HC. Clinical practice. Atopic dermatitis. N Engl J Med 2005;352:2314-2324.


Schram ME, Spuls PI, Leeflang MM, Lindeboom R. EASI (objective) SCORAD and POEM for atopic eczema: responsiveness and minimal clinically important difference. Allergy 2012;67:99-106.


Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993;186:23-31.


Charman CR, Venn AJ, Williams HC. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients’ perspective. Arch Dermatol 2004;140:1513-1519


Darsow U, Wollenberg A, Simon D, Taïeb A, et al. ETFAD/ EADV eczema task force 2009 position paper on diagnosis and treatment of atopic dermatitis. J Eur Acad Dermatol Venereol 2010;24:317-328.


Wüthrich B. Atopic dermatitis flare provoked by inhalant allergens. Dermatologica 1989;178:51-53.


Oppel T, Schuller E, Günther S, Moderer M, et al. Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis. Br J Dermatol 2000;143:1193-1198.


Bieber T. Atopic dermatitis. N Engl J Med 2008;358:1483- 1494.


Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy 2009;64:1498-1506.


Caraballo L, Acevedo N. Allergy in the tropics: the impact of cross-reactivity between mites and ascaris. Front Biosci (Elite Ed) 2011;3:51-64.


Acevedo N, Erler A, Briza P, Puccio F, et al. Allergenicity of Ascaris lumbricoides tropomyosin and IgE sensitization among asthmatic patients in a tropical environment. Int Arch Allergy Immunol 2011;154:195-206.


Bieber T, Cork M, Reitamo S. Atopic dermatitis: a candidate for disease-modifying strategy. Allergy 2012;67:969-975.


Valenta R, Natter S, Seiberler S, Wichlas S, et al. Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. J Invest Dermatol 1998;111:1178-1183.


Valenta R, Natter S, Seiberler S, Grote M. Isolation of cDNAs coding for IgE autoantigens: a link between atopy and autoimmunity. Int Arch Allergy Immunol 1997;113:209-212.


Valenta R, Maurer D, Steiner R, Seiberler S, et al. Immunoglobulin E response to human proteins in atopic patients. J Invest Dermatol 1996;107:203-208.


Bieber T. Atopic dermatitis 2.0: from the clinical phenotype to the molecular taxonomy and stratified medicine. Allergy 2012;67:1475-1482.


Illi S, von Mutius E, Lau S, Nickel R, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol 2004;113:925- 931.


Perkin MR, Strachan DP, Williams HC, Kennedy CT, et al. Natural history of atopic dermatitis and its relationship to serum total immunoglobulin E in a population-based birth cohort study. Pediatr Allergy Immunol 2004;15:221-229.


Garmhausen D, Hagemann T, Bieber T, Dimitriou I, et al. Characterization of different courses of atopic dermatitis in adolescent and adult patients. Allergy 2013;68:498- 506.


Chou JS, LeBovidge J, Timmons K, Elverson W, et al. Predictors of clinical success in a multidisciplinary model of atopic dermatitis treatment. Allergy Asthma Proc 2011;32:377- 383.


Kawamoto N, Fukao T, Kaneko H, Hirayama K, et al. Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months. Allergy Asthma Proc 2013;34:362- 369.


Liu FT, Goodarzi H, Chen HY. IgE, mast cells, and eosinophils in atopic dermatitis. Clin Rev Allergy Immunol 2011;41:298- 310.


Antúnez C, Torres MJ, Mayorga C, Cornejo-García JA, et al. Different cytokine production and activation marker profiles in circulating cutaneous-lymphocyte-associated antigen T cells from patients with acute or chronic atopic dermatitis. Clin Exp Allergy 2004;34:559-566.


Antúnez C, Torres MJ, Corzo JL, Pena RR, et al. Different lymphocyte markers and cytokine expression in peripheral blood mononuclear cells in children with acute atopic dermatitis. Allergol Immunopathol 2004;32:252-258.


Laske N, Bunikowski R, Niggemann B. Extraordinarily high serum IgE levels and consequences for atopic phenotypes. Ann Allergy Asthma Immunol 2003;91:202-204.


Kuanprasert N, Herbert O, Barnetson RS. Clinical improvement and significant reduction of total serum IgE in patients suffering from severe atopic dermatitis treated with oral azathioprine. Australas J Dermatol 2002;43:125-127.


Jolles S, Hughes J, Rustin M. The treatment of atopic dermatitis with adjunctive high-dose intravenous immunoglobulin: a report of three patients and review of the literature. Br J Dermatol 2000;142:551-554.


Pajno GB, Caminiti L, Vita D, Barberio G, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo-controlled study. J Allergy Clin Immunol 2007;120:164-170.


Pajno GB, Barberio G, De Luca F, Morabito L, Parmiani S. Prevention of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. A six-year follow-up study. Clin Exp Allergy 2001;31:1392-1397.


Beriat GK, Akmansu SH, Doğan C, Taştan E, et al. Is pimecrolimus cream (1%) an appropriate therapeutic agent for the treatment of external ear atopic dermatitis? Med Sci Monit 2012;18:135-143


Cordero Miranda MA, Flores Sandoval G, Orea Solano M, Estrada Parra S, Serrano Miranda E. [Safety and efficacy of treatment for severe atopic dermatitis with cyclosporin A and transfer factor]. Rev Alerg Mex 1999;46:49-57.


Sánchez Caraballo JM, Cardona Villa R. Clinical and immunological changes of immunotherapy in patients with atopic dermatitis: randomized controlled trial. ISRN Allergy 2012;2012:183983.


Johnke H, Norberg LA, Vach W, Host A, Andersen KE. Patterns of sensitization in infants and its relation to atopic dermatitis. Pediatr Allergy Immunol 2006;17:591-600.


Lopez N, de Barros-Mazon S, Vilela MM, Condino Neto A, Ribeiro JD. Are immunoglobulin E levels associated with early wheezing? A prospective study in Brazilian infants. Eur Respir J 2002;20:640-645.


Schäfer T, Heinrich J, Wjst M, Adam H, et al. Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren. J Allergy Clin Immunol 1999;104:1280-1284.


Hill DJ, Hosking CS. Food allergy and atopic dermatitis in infancy: an epidemiologic study. Pediatr Allergy Immunol 2004;15:421-427.


Somani VK. A study of allergen-specific IgE antibodies in Indian patients of atopic dermatitis. Indian J Dermatol Venereol Leprol 2008;74:100-104.


Wahn U, Warner J, Simons FE, de Benedictis FM, et al. IgE antibody responses in young children with atopic dermatitis. Pediatr Allergy Immunol 2008;19:332-336.


Sánchez J, Diez S, Cardona R. Sensibilización a aeroalergenos en pacientes alérgicos de Medellín, Colombia. Revista Alergia México 2012;59:139-147.


Sánchez J, Sánchez A. Epidemiology of food allergy in Latin America. Allergol Immunopathol 2013.


Leung DY, Harbeck R, Bina P, Reiser RF, et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest 1993;92:1374-1380.


Langer K, Breuer K, Kapp A, Werfel T. Staphylococcus aureus-derived enterotoxins enhance house dust miteinduced patch test reactions in atopic dermatitis. Exp Dermatol 2007;16:124-129.


Ide F, Matsubara T, Kaneko M, Ichiyama T, et al. Staphylococcal enterotoxin-specific IgE antibodies in atopic dermatitis. Pediatr Int 2004;46:337-341.


Wessels MW, Doekes G, Van Ieperen-Van Kijk AG, Koers WJ, Young E. IgE antibodies to Pityrosporum ovale in atopic dermatitis. Br J Dermatol 1991;125:227-232.


Jensen-Jarolim E, Poulsen LK, With H, Kieffer M, et al. Atopic dermatitis of the face, scalp, and neck: type I reaction to the yeast Pityrosporum ovale? J Allergy Clin Immunol 1992;89:44-51.


Altrichter S, Kriehuber E, Moser J, Valenta R, et al. Serum IgE autoantibodies target keratinocytes in patients with atopic dermatitis. J Invest Dermatol 2008;128:2232-2239.


Boye JI. Food allergies in developing and emerging economies: need for comprehensive data on prevalence rates. Clin Transl Allergy 2012;2:25.


Isolauri E, Turjanmaa K. Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. J Allergy Clin Immunol 1996;97:9- 15.


Niggemann B, Reibel S, Wahn U. The atopy patch test (APT)– a useful tool for the diagnosis of food allergy in children with atopic dermatitis. Allergy 2000;55:281-285.


Vanto T, Juntunen-Backman K, Kalimo K, Klemola T, et al. The patch test, skin prick test, and serum milk-specific IgE as diagnostic tools in cow’s milk allergy in infants. Allergy 1999;54:837-842.


Niggemann B, Reibel S, Roehr CC, Felger D, et al. Predictors of positive food challenge outcome in non-IgE-mediated reactions to food in children with atopic dermatitis. J Allergy Clin Immunol 2001;108:1053-1058.


Majamaa H, Moisio P, Holm K, Turjanmaa K. Wheat allergy: diagnostic accuracy of skin prick and patch tests and specific IgE. Allergy 1999;54:851-856.


Darsow U, Laifaoui J, Kerschenlohr K, Wollenberg A, et al. The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study. Allergy 2004;59:1318-1325.


Levy SA, Dortas Junior SD, Pires AH, Abe AT, et al. Atopy patch test (APT) in the diagnosis of food allergy in children with atopic dermatitis. An Bras Dermatol 2012;87:724-728.


White JM. Patch testing: what allergists should know. Clin Exp Allergy 2012;42:180-185.


Spiewak R. Contact dermatitis in atopic individuals. Curr Opin Allergy Clin Immunol 2012;12:491-497.


Schnuch A, Geier J, Lessmann H, Arnold R, Uter W. Surveillance of contact allergies: methods and results of the Information Network of Departments of Dermatology (IVDK). Allergy 2012;67:847-857.


Rodrigues DF, Neves DR, Pinto JM, Alves MF, Fulgêncio AC. Results of patch-tests from Santa Casa de Belo Horizonte Dermatology Clinic, Belo Horizonte, Brazil, from 2003 to 2010. An Bras Dermatol 2012;87:800-803.


Blancas-Espinosa R, Conde-Salazar L, Pérez-Hortet C. Occupational airborne contact dermatitis from pristinamycin. Contact Dermatitis 2006;54:63-65.


Rivas A, Kepa J, Gaviria M, Rodrigo N. Estudio descriptivo de dermatitis de contacto por cosméticos en Medellín, Colombia. Revista Asociación Colombiana Dermatología 2011;19:262.


Sampson HA, Gerth van Wijk R, Bindslev-Jensen C, Sicherer S, et al. Standardizing double-blind, placebo-controlled oral food challenges: American Academy of Allergy, Asthma & Immunology-European Academy of Allergy and Clinical Immunology PRACTALL consensus report. J Allergy Clin Immunol 2012;130:1260-1274.


Niggemann B, Lange L, Finger A, Ziegert M, et al. Accurate oral food challenge requires a cumulative dose on a subsequent day. J Allergy Clin Immunol 2012;130:261-263.
Madrigal BI, Alfaro AN, Jiménez CC, González GJ. [Adverse reactions to food in daycare children]. Rev Alerg Mex 1996;43:41-44.
Briot A, Deraison C, Lacroix M, Bonnart C, et al. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2- mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med 2009;206:1135-1147.


Huang JT, Abrams M, Tlougan B, Rademaker A, Paller AS. Treatment of Staphylococcus aureus colonization in atopic dermatitis decreases disease severity. Pediatrics 2009;123:808-814.
Méndez J. Manejo de la dermatitis atópica en atención primaria. MEDIFAM 2003;13:75-84.


Verallo-Rowell VM, Dillague KM, Syah-Tjundawan BS. Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis. Dermatitis 2008;19:308-315.


Breternitz M, Kowatzki D, Langenauer M, Elsner P, Fluhr JW. Placebo-controlled, double-blind, randomized, prospective study of a glycerol-based emollient on eczematous skin in atopic dermatitis: biophysical and clinical evaluation. Skin Pharmacol Physiol 2008;21:39-45.


Grimalt R, Mengeaud V, Cambazard F, Group SI. The steroidsparing effect of an emollient therapy in infants with atopic dermatitis: a randomized controlled study. Dermatology 2007;214:61-67.


Szczepanowska J, Reich A, Szepietowski JC. Emollients improve treatment results with topical corticosteroids in childhood atopic dermatitis: a randomized comparative study. Pediatr Allergy Immunol 2008;19:614-618.


Berth-Jones J, Damstra RJ, Golsch S, Livden JK, et al. Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomised, double blind, parallel group study. BMJ 2003;326:1367.


Glazenburg EJ, Wolkerstorfer A, Gerretsen AL, Mulder PG, Oranje AP. Efficacy and safety of fluticasone propionate 0.005% ointment in the long-term maintenance treatment of children with atopic dermatitis: differences between boys and girls? Pediatr Allergy Immunol 2009;20:59-66.


Chiang C, Eichenfield LF. Quantitative assessment of combination bathing and moisturizing regimens on skin hydration in atopic dermatitis. Pediatr Dermatol 2009;26:273-278.


Varothai S, Nitayavardhana S, Kulthanan K. Moisturizers for patients with atopic dermatitis. Asian Pac J Allergy Immunol 2013;31:91-98.


Lodén M, Andersson AC, Anderson C, Bergbrant IM, et al. A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients. Acta Derm Venereol 2002;82:45-47.


Lack G, Fox D, Northstone K, Golding J, Team ALSoPaCS. Factors associated with the development of peanut allergy in childhood. N Engl J Med 2003;348:977-985.


Hoare C, Li Wan Po A, Williams H. Systematic review of treatments for atopic eczema. Health Technol Assess 2000;4:1-191.


Stalder JF, Fleury M, Sourisse M, Rostin M, et al. Local steroid therapy and bacterial skin flora in atopic dermatitis. Br J Dermatol 1994;131:536-540.


Nilsson EJ, Henning CG, Magnusson J. Topical corticosteroids and Staphylococcus aureus in atopic dermatitis. J Am Acad Dermatol 1992;27:29-34.


Korting HC, Kerscher MJ, Schäfer-Korting M. Topical glucocorticoids with improved benefit/risk ratio: do they exist? J Am Acad Dermatol 1992;27:87-92.


Kerscher MJ, Hart H, Korting HC, Stalleicken D. In vivo assessment of the atrophogenic potency of mometasone furoate, a newly developed chlorinated potent topical glucocorticoid as compared to other topical glucocorticoids old and new. Int J Clin Pharmacol Ther 1995;33:187-189.


Chambergo R, Ballona C. Corticoides tópicos en pediatría: una puesta al día. Dermatología peruana 2003;13:163-170.


Thomas KS, Armstrong S, Avery A, Po AL, et al. Randomised controlled trial of short bursts of a potent topical corticosteroid versus prolonged use of a mild preparation for children with mild or moderate atopic eczema. BMJ 2002;324:768.


Ruzicka T, Bieber T, Schöpf E, Rubins A, Dobozy A, Bos JD, et al. A short-term trial of tacrolimus ointment for atopic dermatitis. European Tacrolimus Multicenter Atopic Dermatitis Study Group. N Engl J Med 1997;337:816-821.


Van Leent EJ, Gräber M, Thurston M, Wagenaar A, et al. Effectiveness of the ascomycin macrolactam SDZ ASM 981 in the topical treatment of atopic dermatitis. Arch Dermatol 1998;134:805-809.


Reitamo S, Wollenberg A, Schöpf E, Perrot JL, et al. Safety and efficacy of 1 year of tacrolimus ointment monotherapy in adults with atopic dermatitis. The European Tacrolimus Ointment Study Group. Arch Dermatol 2000;136:999-1006.


Meurer M, Fölster-Holst R, Wozel G, Weidinger G, et al. Pimecrolimus cream in the long-term management of atopic dermatitis in adults: a six-month study. Dermatology 2002;205:271-277.


Wollenberg A, Reitamo S, Atzori F, Lahfa M, et al. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. Allergy 2008;63:742-750.


Luger T, Van Leent EJ, Graeber M, Hedgecock S, et al. SDZ ASM 981: an emerging safe and effective treatment for atopic dermatitis. Br J Dermatol 2001;144:788-794.


Reitamo S, Rustin M, Ruzicka T, Cambazard F, et al. Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitis. J Allergy Clin Immunol 2002;109:547-555.


Bornhövd EC, Burgdorf WH, Wollenberg A. Immunomodulatory macrolactams for topical treatment of inflammatory skin diseases. Curr Opin Investig Drugs 2002;3:708-712.


Lübbe J, Pournaras CC, Saurat JH. Eczema herpeticum during treatment of atopic dermatitis with 0.1% tacrolimus ointment. Dermatology 2000;201:249-251.


Ashcroft DM, Dimmock P, Garside R, Stein K, Williams HC. Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trials. BMJ 2005;330:516.


Kleinböhl D, Trojan J, Konrad C, Hölzl R. Sensitization and habituation of AMH and C-fiber related percepts of repetitive radiant heat stimulation. Clin Neurophysiol 2006;117:118-130.


Bussmann C, Maintz L, Hart J, Allam JP, et al. Clinical improvement and immunological changes in atopic dermatitis patients undergoing subcutaneous immunotherapy with a house dust mite allergoid: a pilot study. Clin Exp Allergy 2007;37:1277-1285.


Einarsson R, Dreborg S, Hammarström L, Löfkvist T, et al. Monitoring of mite dermatophagoides farinae allergenspecific IgG and IgG subclass distribution in patients on immunotherapy. Allergy 1992;47:76-82.


Werfel T, Breuer K, Ruéff F, Przybilla B, et al. Usefulness of specific immunotherapy in patients with atopic dermatitis and allergic sensitization to house dust mites: a multi-centre, randomized, dose-response study. Allergy 2006;61:202-205.


Glover MT, Atherton DJ. A double-blind controlled trial of hyposensitization to dermatophagoides pteronyssinus in children with atopic eczema. Clin Exp Allergy 1992;22:440- 446.


Novak N, Bieber T, Hoffmann M, Fölster-Holst R, et al. Efficacy and safety of subcutaneous allergen-specific immunotherapy with depigmented polymerized mite extract in atopic dermatitis. J Allergy Clin Immunol 2012;130:925- 931.


Huss-Marp J, Eberlein-König B, Breuer K, Mair S, et al. Influence of short-term exposure to airborne Der p 1 and volatile organic compounds on skin barrier function and dermal blood flow in patients with atopic eczema and healthy individuals. Clin Exp Allergy 2006;36:338-345.


Acevedo N, Mercado D, Vergara C, Sánchez J, et al. Association between total immunoglobulin E and antibody responses to naturally acquired ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes. Clin Exp Immunol 2009;157:282-290.


Boyce JA, Assa’ad A, Burks AW, Jones SM, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010;126:1-58.


Montealegre F, Meyer B, Chardon D, Vargas W, et al. Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment. Clin Exp Allergy 2004;34:51-58.


Mandhane PJ, Sears MR, Poulton R, Greene JM, et al. Cats and dogs and the risk of atopy in childhood and adulthood. J Allergy Clin Immunol 2009;124:745-750.


Simpson A. Effect of household pet ownership on infant immune response and subsequent sensitization. J Asthma Allergy 2010;3:131-137.


Sanchez J. Physicochemical characteristics of gaseous and particulate air pollutants. Their impact on asthma Iatreia 2012;25:369-379.


Henz BM, Metzenauer P, O’Keefe E, Zuberbier T. Differential effects of new-generation H1-receptor antagonists in pruritic dermatoses. Allergy 1998;53:180-183.


La Rosa M, Ranno C, Musarra I, Guglielmo F, et al. Doubleblind study of cetirizine in atopic eczema in children. Ann Allergy 1994;73:117-122.


Wahlgren CF, Hägermark O, Bergström R. The antipruritic effect of a sedative and a non-sedative antihistamine in atopic dermatitis. Br J Dermatol 1990;122:545-551.


Munday J, Bloomfield R, Goldman M, Robey H, et al. Chlorpheniramine is no more effective than placebo in relieving the symptoms of childhood atopic dermatitis with a nocturnal itching and scratching component. Dermatology 2002;205:40-45.


Kawashima M, Tango T, Noguchi T, Inagi M, et al. Addition of fexofenadine to a topical corticosteroid reduces the pruritus associated with atopic dermatitis in a 1-week randomized, multicentre, double-blind, placebo-controlled, parallel-group study. Br J Dermatol 2003;148:1212-1221.


Hannuksela M, Kalimo K, Lammintausta K, Mattila T, et al. Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults. Ann Allergy 1993;70:127-133.


Diepgen TL, Group ETotACS. Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months. Pediatr Allergy Immunol 2002;13:278-286.


Gschwandtner M, Mildner M, Mlitz V, Gruber F, et al. Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Allergy 2013;68:37-47.


Heddle RJ, Soothill JF, Bulpitt CJ, Atherton DJ. Combined oral and nasal beclomethasone diproprionate in children with atopic eczema: a randomised controlled trial. Br Med J (Clin Res Ed) 1984;289:651-654.


Schmitt J, Schäkel K, Fölster-Holst R, Bauer A, et al. Prednisolone vs ciclosporin for severe adult eczema. An investigator-initiated double-blind placebo-controlled multicentre trial. Br J Dermatol 2010;162:661-668.


Akdis CA, Akdis M, Bieber T, Bindslev-Jensen C, et al. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Report. J Allergy Clin Immunol 2006;118:152-169.


Patrizi A, Savoia F, Giacomini F, Tabanelli M, Gurioli C. The effect of summer holidays and sun exposure on atopic dermatitis. G Ital Dermatol Venereol 2009;144:463-466.


Tintle S, Shemer A, Suárez-Fariñas M, Fujita H, et al. Reversal of atopic dermatitis with narrow-band UVB phototherapy and biomarkers for therapeutic response. J Allergy Clin Immunol 2011;128:583-593.


Clayton TH, Clark SM, Turner D, Goulden V. The treatment of severe atopic dermatitis in childhood with narrowband ultraviolet B phototherapy. Clin Exp Dermatol 2007;32:28- 33.


Dotterud LK, Wilsgaard T, Vorland LH, Falk ES. The effect of UVB radiation on skin microbiota in patients with atopic dermatitis and healthy controls. Int J Circumpolar Health 2008;67:254-260.


Hong SP, Kim MJ, Jung MY, Jeon H, et al. Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. J Invest Dermatol 2008;128:2880-2887.


Suh KS, Kang JS, Baek JW, Kim TK, et al. Efficacy of ultraviolet A1 phototherapy in recalcitrant skin diseases. Ann Dermatol 2010;22:1-8.


Meduri NB, Vandergriff T, Rasmussen H, Jacobe H. Phototherapy in the management of atopic dermatitis: a systematic review. Photodermatol Photoimmunol Photomed 2007;23:106-112.


Chuang TY, Heinrich LA, Schultz MD, Reizner GT, et al. PUVA and skin cancer. A historical cohort study on 492 patients. J Am Acad Dermatol 1992;26:173-177.


Tzaneva S, Kittler H, Holzer G, Reljic D, et al. 5-Methoxypsoralen plus ultraviolet (UV) A is superior to medium-dose UVA1 in the treatment of severe atopic dermatitis: a randomized crossover trial. Br J Dermatol 2010;162:655-660.


Casara C, Eidt L, Cunha V. Prevalence study of dermatoses referred to the phototherapy unit at the Dermatology Service of the Clinics Hospital of Porto Alegre, RS, Brazil. An Bras Dermatol 2013;88:211-215.


Salek MS, Finlay AY, Luscombe DK, Allen BR, et al. Cyclosporin greatly improves the quality of life of adults with severe atopic dermatitis. A randomized, double-blind, placebo-controlled trial. Br J Dermatol 1993;129:422-430.


Van Joost T, Heule F, Korstanje M, van den Broek MJ, et al. Cyclosporin in atopic dermatitis: a multicentre placebocontrolled study. Br J Dermatol 1994;130:634-640.


Schmitt J, Schmitt N, Meurer M. Cyclosporin in the treatment of patients with atopic eczema-a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2007;21:606-619.


Ballester I, Silvestre JF, Pérez-Crespo M, Lucas A. [Severe adult atopic dermatitis: treatment with mycophenolate mofetil in 8 patients]. Actas Dermosifiliogr 2009;100:883- 887.


Heller M, Shin HT, Orlow SJ, Schaffer JV. Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients. Br J Dermatol 2007;157:127-132.


Haeck IM, Knol MJ, Ten Berge O, van Velsen SG, et al. Enteric-coated mycophenolate sodium versus cyclosporin a as long-term treatment in adult patients with severe atopic dermatitis: a randomized controlled trial. J Am Acad Dermatol 2011;64:1074-1084.


Berth-Jones J, Takwale A, Tan E, Barclay G, Agarwal S, et al. Azathioprine in severe adult atopic dermatitis: a doubleblind, placebo-controlled, crossover trial. Br J Dermatol 2002;147:324-330.


Meggitt SJ, Gray JC, Reynolds NJ. Azathioprine dosed by thiopurine methyltransferase activity for moderate-tosevere atopic eczema: a double-blind, randomised controlled trial. Lancet 2006;367:839-846.


Murphy LA, Atherton D. A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression. Br J Dermatol 2002;147:308- 315.


Schram ME, Roekevisch E, Leeflang MM, Bos JD, et al. A randomized trial of methotrexate versus azathioprine for severe atopic eczema. J Allergy Clin Immunol 2011;128:353-359.


Weatherhead SC, Wahie S, Reynolds NJ, Meggitt SJ. An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema. Br J Dermatol 2007;156:346-351.


Lyakhovitsky A, Barzilai A, Heyman R, Baum S, et al. Lowdose methotrexate treatment for moderate-to-severe atopic dermatitis in adults. J Eur Acad Dermatol Venereol 2010;24:43-49.


Kalliomäki M, Salminen S, Arvilommi H, Kero P, et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-1079.


Kalliomäki M, Salminen S, Poussa T, Arvilommi H, Isolauri E. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 2003;361:1869-1871.


Osborn DA, Sinn JK. Probiotics in infants for prevention of allergic disease and food hypersensitivity. Cochrane Database Syst Rev. 2007;4:6475.


Dotterud CK, Storro O, Johnsen R, Oien T. Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial. Br J Dermatol. 2010;163:616-623.


Zakzuk J, Solano A, Sanchez J, Acevedo N, et al. Altered composition of gut microflora in wheezing infants from cartagena, a tropical city of Colombia. J Allergy Clin Immunol 2011;127:224.


Williams HC, Grindlay DJ. What’s new in atopic eczema? An analysis of systematic reviews published in 2007 and 2008. Part 2. Disease prevention and treatment. Clin Exp Dermatol 2010;35:223-227.


Bath-Hextall FJ, Jenkinson C, Humphreys R, Williams HC. Dietary supplements for established atopic eczema. Cochrane Database Syst Rev 2012;2:5205.


Osborn DA, Sinn JK. Prebiotics in infants for prevention of allergy. Cochrane Database Syst Rev 2013;3:6474.


Caruso C, Gaeta F, Valluzzi RL, Romano A. Omalizumab efficacy in a girl with atopic eczema. Allergy 2010;65:278-279.


Park SY, Choi MR, Na JI, Youn SW, et al. Recalcitrant atopic dermatitis treated with omalizumab. Ann Dermatol 2010;22:349-352.


Lane JE, Cheyney JM, Lane TN, Kent DE, Cohen DJ. Treatment of recalcitrant atopic dermatitis with omalizumab. J Am Acad Dermatol 2006;54:68-72.


Belloni B, Ziai M, Lim A, Lemercier B, et al. Low-dose anti-IgE therapy in patients with atopic eczema with high serum IgE levels. J Allergy Clin Immunol 2007;120:1223-1225.


Sheinkopf LE, Rafi AW, Do LT, Katz RM, Klaustermeyer WB. Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study. Allergy Asthma Proc 2008;29:530-537.


Heil PM, Maurer D, Klein B, Hultsch T, Stingl G. Omalizumab therapy in atopic dermatitis: depletion of IgE does not improve the clinical course-a randomized, placebocontrolled and double blind pilot study. J Dtsch Dermatol Ges 2010;8:990-998.


Iyengar SR, Hoyte EG, Loza A, Bonaccorso S, et al. Immunologic effects of omalizumab in children with severe refractory atopic dermatitis: a randomized, placebo-controlled clinical trial. Int Arch Allergy Immunol 2013;162:89-93.


Jang IG, Yang JK, Lee HJ, Yi JY, et al. Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma. J Am Acad Dermatol 2000;42:1033-1040.


Simon D, Hösli S, Kostylina G, Yawalkar N, Simon HU. Anti- CD20 (rituximab) treatment improves atopic eczema. J Allergy Clin Immunol 2008;121:122-128.


Sedivá A, Kayserová J, Vernerová E, Poloucková A, et al. Anti-CD20 (rituximab) treatment for atopic eczema. J Allergy Clin Immunol 2008;121:1515-1516.


Ponte P, Lopes MJ. Apparent safe use of single dose rituximab for recalcitrant atopic dermatitis in the first trimester of a twin pregnancy. J Am Acad Dermatol 2010;63:355-356.


Ibler K, Dam TN, Gniadecki R, Kragballe K, et al. Efalizumab for severe refractory atopic eczema: retrospective study on 11 cases. J Eur Acad Dermatol Venereol 2010;24:837-839.


Bremmer MS, Bremmer SF, Baig-Lewis S, Simpson EL. Are biologics safe in the treatment of atopic dermatitis? A review with a focus on immediate hypersensitivity reactions. J Am Acad Dermatol 2009;61:666-676.


Jee SJ, Kim JH, Baek HS, Lee HB, Oh JW. Long-term Efficacy of Intravenous Immunoglobulin Therapy for Moderate to Severe Childhood Atopic Dermatitis. Allergy Asthma Immunol Res 2011;3:89-95.


Pittler MH, Armstrong NC, Cox A, Collier PM, et al. Randomized, double-blind, placebo-controlled trial of autologous blood therapy for atopic dermatitis. Br J Dermatol. 2003;148:307-313.


DiNicola C, Kekevian A, Chang C. Integrative medicine as adjunct therapy in the treatment of atopic dermatitis–the role of traditional Chinese medicine, dietary supplements, and other modalities. Clin Rev Allergy Immunol 2013;44:242- 253.


Zhang W, Leonard T, Bath-Hextall F, Chambers CA, et al. Chinese herbal medicine for atopic eczema. Cochrane Database Syst Rev 2005:2291.


Buhles N, Wehrmann J, Hinsch KD, Nürnberg W, et al. S1 Guideline: Dermatological inpatient rehabilitation in adult atopic dermatitis. J Dtsch Dermatol Ges 2011;9:558-561.


Holling H, Depner C, Musekamp G, Stachow R, Janssen H. Effects of inpatient rehabilitation for children with atopic dermatitis: a prospective controlled evaluation study. J Eval Clin Pract 2010;16:1364-1367.


Reinholz M, Ruzicka T, Schauber J. Vitamin D and its role in allergic disease. Clin Exp Allergy 2012;42:817-826.


Bäck O, Blomquist HK, Hernell O, Stenberg B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol 2009;89:28-32.


Hyppönen E, Sovio U, Wjst M, Patel S, et al. Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann N Y Acad Sci 2004;1037:84-95.


Nwaru BI, Ahonen S, Kaila M, Erkkola M, et al. Maternal diet during pregnancy and allergic sensitization in the offspring by 5 yrs of age: a prospective cohort study. Pediatr Allergy Immunol 2010;21:29-37.


Foolad N, Brezinski EA, Chase EP, Armstrong AW. Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids. JAMA Dermatol 2013;149:350-355.


Palmer DJ, Sullivan T, Gold MS, Prescott SL, et al. Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. BMJ 2012;344:184.


Pelucchi C, Galeone C, Bach JF, La Vecchia C, Chatenoud L. Pet exposure and risk of atopic dermatitis at the pediatric age: A meta-analysis of birth cohort studies. J Allergy Clin Immunol 2013;132:616-622.


Boguniewicz M, Leung DY. Recent insights into atopic dermatitis and implications for management of infectious complications. J Allergy Clin Immunol 2010;125:4-13.


Bath-Hextall FJ, Birnie AJ, Ravenscroft JC, Williams HC. Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review. Br J Dermatol 2010;163:12-26.


Sidbury R, Sullivan AF, Thadhani RI, Camargo CA. Randomized controlled trial of vitamin D supplementation for winter-related atopic dermatitis in Boston: a pilot study. Br J Dermatol 2008;159:245-247.


Hata TR, Kotol P, Jackson M, Nguyen M, et al. Administration of oral vitamin D induces cathelicidin production in atopic individuals. J Allergy Clin Immunol 2008;122:829-831.


Babalola O, Strober BE. Treatment of atopic dermatitis in pregnancy. Dermatol Ther 2013;26:293-301.


Cho S, Kim HJ, Oh SH, Park CO, et al. The influence of pregnancy and menstruation on the deterioration of atopic dermatitis symptoms. Ann Dermatol 2010;22:180-185.


Koutroulis I, Papoutsis J, Kroumpouzos G. Atopic dermatitis in pregnancy: current status and challenges. Obstet Gynecol Surv 2011;66:654-663.


Weatherhead S, Robson SC, Reynolds NJ. Eczema in pregnancy. BMJ 2007;335:152-154.


Kar S, Krishnan A, Preetha K, Mohankar A. A review of antihistamines used during pregnancy. J Pharmacol Pharmacother 2012;3:105-108.


Orru S, Di Nicola P, Giuliani F, Fabris C, et al. Detection of bovine alpha-S1-casein in term and preterm human colostrum with proteomic techniques. Int J Immunopathol Pharmacol 2013;26:435-444.


Paveglio S, Puddington L, Rafti E, Matson AP. FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice. Clin Exp Allergy 2012;42:1791-1800.


Verhasselt V, Milcent V, Cazareth J, Kanda A, et al. Breast milk-mediated transfer of an antigen induces tolerance and protection from allergic asthma. Nat Med 2008;14:170-175.


De Bruin Weller MS, Rockmann H, Knulst AC, Bruijnzeel- Koomen CA. Evaluation of the adult patient with atopic dermatitis. Clin Exp Allergy 2013;43:279-291.

Silverberg JI, Simpson EL. Association between severe eczema in children and multiple comorbid conditions and increased healthcare utilization. Pediatr Allergy Immunol 2013;24:476-486.


Yaghmaie P, Koudelka CW, Simpson EL. Mental health comorbidity in patients with atopic dermatitis. J Allergy Clin Immunol 2013;131:428-433.


Ring J, Alomar A, Bieber T, Deleuran M, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) part I. J Eur Acad Dermatol Venereol 2012;26:1045-1060.


Ring J, Alomar A, Bieber T, Deleuran M, et al. Guidelines for treatment of atopic eczema (atopic dermatitis) Part II. J Eur Acad Dermatol Venereol 2012;26:1176-1193.


Saeki H, Furue M, Furukawa F, Hide M, et al. Guidelines for management of atopic dermatitis. J Dermatol 2009;36:563- 577.


Rubel D, Thirumoorthy T, Soebaryo RW, Weng SC, et al. Consensus guidelines for the management of atopic dermatitis: an Asia-Pacific perspective. J Dermatol 2013;40:160-171.


Schneider L, Tilles S, Lio P, Boguniewicz M, et al. Atopic dermatitis: a practice parameter update 2012. J Allergy Clin Immunol 2013;131:295-299.
Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Derechos de autor 2014 Revista Alergia México

Descargas

##plugins.themes.healthSciences.displayStats.noStats##