Resumen
Antecedentes: La alergia al cacahuate en adultos con enfermedades respiratorias alérgicas pocas veces ha sido estudiada en México.
Objetivo: Establecer la prevalencia de alergia al cacahuate en un grupo de adultos con asma o rinitis alérgica; también se describen los síntomas asociados con la alergia al cacahuate.
Métodos: Se realizó estudio transversal en el que analizaron los datos correspondientes a 257 pacientes con enfermedades respiratorias alérgicas, asma o rinitis alérgica, con edad igual o mayor a 16 años; los pacientes fueron reclutados consecutivamente. La alergia al cacahuate se determinó por una prueba cutánea positiva al cacahuate y a través de una entrevista estandarizada. Se estimaron intervalos de confianza (IC) a 95 % para proporciones.
Resultados: De los pacientes incluidos, 18 estuvieron sensibilizados al cacahuate (7.0 %, IC 95 % = 4.4-10.9), siete de ellos fueron considerados alérgicos al cacahuate, para una prevalencia de 2.7% (IC 95%: 1.2% - 5.6%). En los pacientes con alergia al cacahuate, los síntomas predominantes fueron los orales, principalmente el prurito en la faringe y en el paladar, seguidos de edema de los labios; entre las molestias respiratorias sobresalieron los estornudos y la rinorrea y, al final, los síntomas cutáneos. No se documentaron reacciones sistémicas al cacahuate.
Conclusión: En nuestro estudio, la alergia al cacahuate en adultos con enfermedades respiratorias alérgicas no fue infrecuente.
Referencias
Tham EH, Leung DYM. how different parts of the world provide new insights into food allergy. Allergy Asthma Immunol Res. 2018;10(4):290-299. DOI: 10.4168/aair.2018.10.4.290
Samady W, Trainor J, Smith B, Gupta R. Food-induced Anaphylaxis in Infants and Children. Ann Allergy Asthma Immunol. 2018;121(3):360-365. DOI: 10.1016/j.anai.2018.05.025
Katz Y. Food allergy epidemic: can we reverse the trend? Isr Med Assoc J. 2012;14(1):5-6. Available in: https://www.ima.org.il/FilesUpload/IMAJ/0/38/19313.pdf
Togias A, Cooper SF, Acebal ML, Assa’ad A, Baker JR, Beck LA, et al. Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases sponsored expert panel. World Allergy Organ J. 2017;10(1):1. DOI: 10.1186/s40413-016-0137-9
Bedolla-Barajas M, Valdez-López F, Alcalá-Padilla M, Bedolla-Pulido TI, Rivera-Mejia V. Morales-Romero J. Prevalence and factors associated to peanut allergy in Mexican school children. Allergol Immunopathol (Madr). 2017;45(1):69-76. DOI: 10.1016/j.aller.2016.04.013
Sánchez J, Sánchez A. Epidemiology of food allergy in Latin America. Allergol Immunopathol (Madr). 2015;43(2):185-195. DOI: 10.1016/j.aller.2013.07.001
Walker MT, Green JE, Ferrie RP, Queener AM, Kaplan MH, Cook-Mills JM. Mechanism for initiation of food allergy: dependence on skin barrier mutations and environmental allergen costimulation. J Allergy Clin Immunol. 2018;141(5):1711-1725. DOI: 10.1016/j.jaci.2018.02.003
Foong RX, Brough H. The role of environmental exposure to peanut in the development of clinical allergy to peanut. Clin Exp Allergy. 2017;47(10):1232-1238. DOI: 10.1111/cea.12992
Van Kampen V, De Blay F, Folletti I, et al. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy. 2013;68(5):580-584. DOI: 10.1111/all.12120
Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: Health Nuts age 4 year follow up. J Allergy Clin Immunol. 2017;140(1):145-153. DOI: 10.1016/j.jaci.2017.02.019
Wang Y, Allen KJ, Suaini NHA, Peters RL, Ponsonby AL, Koplin JJ. Asian children living in Australia have a different profile of allergy and anaphylaxis than Australian-born children: a State-wide survey. Clin Exp Allergy. 2018;48(10):1317-1324. DOI: 10.1111/cea.13235
Husain Z, Schwartz RA. Peanut allergy: an increasingly common life-threatening disorder. J Am Acad Dermatol. 2012;66(1):136-143. DOI: 10.1016/j.jaad.2011.02.031
Lee AJ, Thalayasingam M, Lee BW. Food allergy in Asia: how does it compare? Asia Pac Allergy. 2013;3(1):3-14. DOI: 10.5415/apallergy.2013.3.1.3
Dunlop JH, Keet CA. Epidemiology of food allergy. Immunol Allergy Clin North Am. 2018;38(1):13-25. DOI: 10.1016/j.iac.2017.09.002
Cabanillas B, Novak N. Effects of daily food processing on allergenicity. Crit Rev Food Sci Nutr. 2019;59(1):31-42. DOI: 10.1080/10408398.2017.1356264
Fleischer DM, Sicherer S, Greenhawt M, Campbell D, Chan E, Muraro A, et al. Consensus communication on early peanut introduction and prevention of peanut allergy in high-risk infants. Ann Allergy Asthma Immunol. 2015;115(2):87-90. DOI: 10.1016/j.anai.2015.06.001
Asai Y, Eslami A, Van Ginkel CD, Akhabir L, Wan M, Ellis G, et al. Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy. J Allergy Clin Immunol. 2018;141(3):991-1001. DOI: 10.1016/j.jaci.2017.09.015
Platts-Mills TA. The allergy epidemics: 1870-2010. J Allergy Clin Immunol. 2015;136(1):3-13. DOI: 10.1016/j.jaci.2015.03.048
Gray CL, Levin ME, Du Toit G. Which test is best for diagnosing peanut allergy in South African children with atopic dermatitis? S Afr Med J. 2016;106(2):214-220. DOI: 10.7196/SAMJ.2016.v106i2.10125
Tham EH, Shek LP, Van Bever HP, Vichyanond P, Ebisawa M, Wong GW, et al. Early introduction of allergenic foods for the prevention of food allergy from an Asian perspective-an Asia Pacific Association of Pediatric Allergy, Respirology & Immunology (APAPARI) consensus statement. Pediatr Allergy Immunol. 2018;29(1):18-27. DOI: 10.1111/pai.12820
Strachan DP. Family size, infection and atopy: the first decade of the ‘‘hygiene hypothesis”. Thorax. 2000;55(Suppl 1):S2-S10. DOI: 10.1136/thorax.55.suppl_1.s2
Iweala OI, Choudhary SK, Commins SP. Food allergy. Curr Gastroenterol Rep. 2018;20(5):17. DOI: 10.1007/s11894-018-0624-y
Kazatsky AM, Wood RA. Classification of Food Allergens and Cross-Reactivity. Curr Allergy Asthma Rep. 2016; 16:22.
Park KH, Son YW, Lee SC, Jeong K, Sim da DW, Park HJ, et al. Clinical significance of component allergens in fagales pollen sensitized peanut allergy in Korea. Allergy Asthma Immunol Res. 2016;8(6):505-511. DOI: 10.4168/aair.2016.8.6.505
Valcour A, Jones JE, Lidholm J, Borres MP, Hamilton RG. Sensitization profiles to peanut allergens across the United States. Ann Allergy Asthma Immunol. 2017;119(3):262-266. DOI: 10.1016/j.anai.2017.06.021
Bedolla-Barajas M, Morales-Romero J, Ortiz-Miramontes LR, Jáuregui-Franco RO. Frequency and clinical features of the oral allergy syndrome in Mexican Adults with nasal pollinosis. Rev Alerg Mex. 2013;60(1):17-25.
Bartnikas LM, Huffajer MF, Sheehan WJ, Kanchongkittiphon W, Pretty CR, Leibowitz R, et al. Impact of school peanut free policies on epinephrine administration. J Allergy Clin Immunol. 2017;140(2):465-473. DOI: 10.1016/j.jaci.2017.01.040
Moreno MA. Guidelines to help prevent peanut allergy. JAMA Pediatr. 2017;171(1):100. DOI: 10.1001/jamapediatrics.2016.3085
Leickly FE, Kloepfer KM, Slaven JE, Vitalpur G. Peanut allergy: an epidemiologic analysis of a large database. J Pediatr. 2018;192:223-228. DOI: 10.1016/j.jpeds.2017.09.026
Bedolla-Barajas M, Bedolla-Pulido TR, Camacho-Peña AS, González-García E, Morales-Romero J. Food hypersensitivity in Mexican adults at 18 to 50 years of age: a questionnaire survey. Allergy Asthma Immunol Res. 2014;6(6):511-516. DOI: 10.4168/aair.2014.6.6.511
Thong BY, Arulanandam S, Tan SC, Tan TC, Chan GY, Tan JW, et al. Shellfish/crustacean oral allergy syndrome among national service pre-enlistees in Singapore. Asia Pac Allergy. 2018;8(2):e18. DOI: 10.5415/apallergy.2018.8.e18
Sampson HA. Anaphylaxis and emergency treatment. Pediatrics. 2003;111(6 Pt 3):1601-1608. Available in: https://pediatrics.aappublications.org/content/111/Supplement_3/1601.long
Wassenberg J, Cochard MM, Dunngalvin A, Ballabeni P, Flokstra-De Blok BM, Newman CJ, et al. Parent perceived quality of life is age-dependent in children with food allergy. Pediatr Allergy Immunol. 2012;23(5):412-419. DOI: 10.1111/j.1399-3038.2012.01310.x
Patel DR, Upton JEM, Wang J, Harada L, Guffey D, Minard CG, et al. Quality of life for parents of children with food allergy in peanut-restricted versus peanut-free schools in the United States and Canada. J Allergy Clin Immunol Pract. 2018;6(2):671-673. DOI: 10.1016/j.jaip.2017.08.013
Simms E, Foster G, Arias K, Larché M, Freitag T, Walker T, et al. Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012-2015. Allergy Asthma Clin Immunol. 2017;13:10. DOI: 10.1186/s13223-017-0179-8
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Derechos de autor 2019 Revista Alergia México