Dupilumab en el tratamiento del asma

Autores/as

DOI:

https://doi.org/10.29262/ram.v67i7.779

Palabras clave:

asma, dupilumab, tratamiento, monoclonal, FEV1, exacerbacion

Resumen

Dupilumab es un anticuerpo monoclonal humano contra receptores de interleucina (IL)-4 e IL-4/IL-13. Estas son citocinas clave en la génesis de la inflamación tipo 2, predominante en los pacientes con asma. Los ensayos clínicos que evalúan la eficacia de dupilumab incluyen tres ensayos pivotales controlados versus placebo fase 2b o 3 de 24 a 52 semanas en pacientes ≥ 12 años, con asma moderada a grave (no controlada con dosis media a alta de corticosteroides inhalados) o asma grave (dependiente de corticosteroides orales). En estos estudios, la suma de dupilumab al tratamiento se toleró adecuadamente y redujo la tasa de exacerbaciones graves, mejoró la función pulmonar, así como el control del asma y la calidad de vida, de igual forma redujo las dosis de corticosteroides sistémicos orales sin afectar el control. Dupilumab mostró eficacia en varios subgrupos de pacientes, aunque aquellos con inflamación tipo 2 mostraron un beneficio más destacado. Dupilumab está indicado (y es una opción terapéutica valiosa) en pacientes ≥ 12 años de edad que tienen asma de moderada o grave con inflamación tipo 2/fenotipo eosinofílico, descontrolada a pesar de los tratamientos convencionales o en aquellos con dependencia a corticosteroides sistémicos orales para el control.

Biografía del autor/a

Blanca E. Del Río-Navarro, Hospital Infantil de México Federico Gómez, Servicio de Alergia e Inmunología Clínica, Ciudad de México

Jefa del Servicio de Alergia e Inmunología Clínica, Hospital Infantil de México Federico Gómez

Ana del Carmen García-González, Medical Affairs- Inmunología, Sanofi-Genzyme

Medical Scientific Liaison- Inmunología, Sanofi-Genzyme, Ciudad de México

Alberto Valencia, Medical Scientific Liaison-Inmunología, Sanofi Genzyme, Ciudad de México

Medical Scientific Liaison- Inmunología, Sanofi-Genzyme

Citas

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2020-12-16 — Actualizado el 2021-01-21

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