Keywords
SARS-CoV-2
COVID-19
Abstract
The COVID-19 pandemic has collapsed the health systems of many countries in the world and comorbidities in adults have exponentially increased their mortality; in matters of asthma, it has not been possible to establish a defining relationship in mortality. The clinical manifestations of asthmatic patients with SARS COV 2 are presented in a wide range; from asymptomatic to those who experience acute respiratory failure. The most sensitive method for the diagnosis of SARS-CoV-2 infection is RT-PCR. Antigen and serologic tests are quicker than RT-PCR, but they are less sensitive. Radiologic studies and the computed tomography of the chest assist in the diagnosis and follow-up of SARS-CoV-2 infection. The use of spirometry for diagnosis and follow-up is restricted due to the elevated risk of contagion. It has been shown that eosinophilia and TH2 inflammation, due to their antiviral immune effect, are protective factors against severe SARS-CoV-2/COVID-19. Patients with mild asthma express less angiotensin converting enzyme receptors (ACE2), and those with neutrophilic asthma express it in greater proportion, which suggests more severe presentations of COVID-19. The conventional asthma treatment modulates the SARS-CoV-2/COVID-19 immune response, which is why patients with controlled asthma have non-severe manifestations of COVID 19, however, the mechanisms are not clear.
References
Terry PD, Heidel RE, Dhand R. Asthma in adult patients with COVID-19. prevalence and risk of severe disease. Am J Respir Crit Care Med. 2021;203(7):893-905. DOI: 10.1164/rccm.202008-3266OC
Wang Y, Chen J, Chen W, Liu L, Dong M, Ji J, et al. Does asthma increase the mortality of patients with COVID-19?: a systematic review and meta-analysis. Int Arch Allergy Immunol. 2021;182(1):76-82. DOI: 10.1159/000510953
Dirección General de Epidemiología. COVID-19 México: información general. Gobierno de México; 2021 [Consultado el 05 Oct 21]. Disponible en: https://datos.covid-19.conacyt.mx/
Hou H, Xu J, Li Y, Wang Y, Yang H. The association of asthma with COVID-19 mortality: an updated meta-analysis based on adjusted effect estimates. J Allergy Clin Immunol Pract. 2021;9(11):3944-68.e5. DOI: 10.1016/j.jaip.2021.08.016
Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LFP. The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol. 2020;20(6):363-74. DOI: 10.1038/s41577-020-0311-8
Parasher A. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J. 2021;97(1147):312-20. DOI: 10.1136/postgradmedj-2020-138577
Ramakrishnan RK, Al Heialy S, Hamid Q. Implications of preexisting asthma on COVID-19 pathogenesis. Am J Physiol Lung Cell Mol Physiol. 2021;320(5):L880-91. DOI: 10.1152/ajplung.00547.2020
Ho KS, Howell D, Rogers L, Narasimhan B, Verma H, Steiger D. The relationship between asthma, eosinophilia, and outcomes in coronavirus disease 2019 infection. Ann Allergy Asthma Immunol. 2021;127(1):42-8. DOI: 10.1016/j.anai.2021.02.021
Ferastraoaru D, Hudes G, Jerschow E, Jariwala S, Karagic M, de Vos G, et al. Eosinophilia in asthma patients is protective against severe COVID-19 illness. J Allergy Clin Immunol Pract. 2021 Mar;9(3):1152-62.e3. DOI: 10.1016/j.jaip.2020.12.045
Gaspar-Marques J, van Zeller M, Carreiro-Martins P, Chaves Loureiro C. Severe asthma in the era of COVID-19: a narrative review. Pulmonology. 2021:S2531-0437(21)00089-1. DOI: 10.1016/j.pulmoe.2021.04.001
Sarıoğlu N. Asthma and COVID-19: what do we know? Tuberk Toraks. 2020;68(2):141-7. DOI: 10.5578/tt.69775
Abrams EM, Sinha I, Fernandes RM, Hawcutt DB. Pediatric asthma and COVID-19: the known, the unknown, and the controversial. Pediatr Pulmonol. 2020;55(12):3573-8. DOI: 10.1002/ppul.25117
Ochoa-Avilés AM, Ochoa-Avilés C, Morillo-Argudo DA, Molina-Cando MJ, Rodas-Espinoza CR, Chis Ster I, et al. Impact of COVID-19 pandemic on asthma symptoms and management: a prospective analysis of asthmatic children in Ecuador. World Allergy Organ J. 2021;14(6):100551. DOI 10.1016/j.waojou.2021.100551
Chhiba KD, Patel GB, Vu THT, Chen MM, Guo A, Kudlaty E, et al. Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19. J Allergy Clin Immunol. 2020;146(2):307-14.e4. DOI: 10.1016/j.jaci.2020.06.010
Codispoti CD, Bandi S, Patel P, Mahdavinia M. Clinical course of asthma in 4 cases of coronavirus disease 2019 infection. Ann Allergy Asthma Immunol. 2020;125(2):208-10. DOI: 10.1016/j.anai.2020.05.009
Haroun-Díaz E, Vázquez-de la Torre M, Ruano FJ, Somoza-Álvarez ML, Alzate DP, González PL, et al. Severe asthma during the COVID-19 pandemic: clinical observations. J Allergy Clin Immunol Pract. 2020;8(8):2787-9. DOI: 10.1016/j.jaip.2020.06.033
Johnston SL. Asthma and COVID-19: Is asthma a risk factor for severe outcomes? Allergy. 2020;75(7):1543-5. DOI: 10.1111/all.14348
Salahshoori I, Mobaraki-Asl N, Seyfaee A, Mirzaei Nasirabad N, Dehghan Z, Faraji M, et al. Overview of COVID-19 disease: Virology, epidemiology, prevention diagnosis, treatment, and vaccines. Biologics. 2021;1(1):2-40. DOI: 10.3390/biologics1010002
Zahan MN, Habibi H, Pencil A, Abdul-Ghafar J, Ahmadi SA, Juyena NS, et al. Diagnosis of Covid-19 in symptomatic patients: an updated review. Vacunas. 2021. DOI: 10.1016/j.vacun.2021.06.002.
Pascarella G, Strumia A, Piliego C, Bruno F, Del Buono R, Costa F, et al. COVID-19 diagnosis and management: a comprehensive review. J Intern Med. 2020;288(2):192-206. DOI: 10.1111/joim.13091
Chams N, Chams S, Badran R, Shams A, Araji A, Raad M, et al. COVID-19: a multidisciplinary review. Front Public Health. 2020;8:383. DOI: 10.3389/fpubh.2020.00383
Lai CKC, Lam W. Laboratory testing for the diagnosis of COVID-19. Biochem Biophys Res Commun. 2021;538:226-30. DOI: 10.1016/j.bbrc.2020.10.069
Sánchez-Oro R, Torres-Nuez J, Martínez-Sanz G. Radiological findings for diagnosis of SARS-CoV-2 pneumonia (COVID-19). Med Clin (Barc). 2020;155(1):36-40. DOI: 10.1016/j.medcli.2020.03.004
Martínez-Chamorro E, Díez-Tascón A, Ibáñez-Sanz L, Ossaba Vélez S, Borruel-Nacenta S. Radiologic diagnosis of patients with COVID-19. Radiologia (Engl Ed). 2021;63(1):56-73. DOI: 10.1016/j.rx.2020.11.001
Díaz-Campos RM, García-Moguel I, Pina-Maiquez I, Fernández-Rodríguez C, Melero-Moreno C. Prevalence and Influence of COVID-19 in asthma control and lung function in severe asthma patients receiving biological treatment. J Investig Allergol Clin Immunol. 2021;31(4):362-3. DOI: 10.18176/jiaci.0695.
Lovinsky-Desir S, Deshpande DR, De A, Murray L, Stingone JA, Chan A, et al: Asthma among hospitalized patients with COVID-19 and related outcomes. J Allergy Clin Immunol. 2020;146(5):1027-34.e4. DOI: 10.1016/j.jaci.2020.07.026
Rosenthal JA, Awan SF, Fintzi J, Keswani A, Ein D. Asthma is associated with increased risk of intubation but not hospitalization or death in coronavirus disease 2019. Ann Allergy Asthma Immunol. 2021;126(1):93-5. DOI: 10.1016/j.anai.2020.10.002
Centers for Disease Control and Prevention. Coronavirus Disease 2019 (COVID-19): People with moderate to severe asthma. U.S. 2021 [Consultado el 16 Oct 2021]. Disponible en: https://www.cdc.gov/coronavirus/2019-ncov/need-extra-precautions/asthma.html
Akenroye AT, Wood R, Keet C. Asthma, biologics, corticosteroids, and coronavirus disease 2019. Ann Allergy Asthma Immunol. 2020;125(1):12-3. doi: 10.1016/j.anai.2020.05.001
Morais-Almeida M, Aguiar R, Martin B, Ansotegui IJ, Ebisawa M, Arruda LK, et al. COVID-19, asthma, and biological therapies: what we need to know. World Allergy Organ J. 2020 May 16;13(5):100126. DOI: 10.1016/j.waojou.2020.100126
Beaney T, Salman D, Samee T, Mak V. Assessment and management of adults with asthma during the covid-19 pandemic. BMJ. 2020;369:m2092. DOI: 10.1136/bmj.m2092
Kouri A, Gupta S, Yadollahi A, Ryan CM, Gershon AS, To T, et al. Addressing reduced laboratory-based pulmonary function testing during a pandemic. Chest. 2020;158(6):2502-10. DOI: 10.1016/j.chest.2020.06.065
Barker-Davies RM, O’Sullivan O, Senaratne KPP, Baker P, Cranley M, Dharm-Datta S, et al. The Stanford Hall consensus statement for post-COVID-19 rehabilitation. Br J Sports Med. 2020;54(16):949-59. DOI: 10.1136/bjsports-2020-102596
Garvey C, Bayles MP, Hamm LF, Hill K, Holland A, Limberg TM, et al: Rehabilitation Exercise Prescription in Chronic Obstructive Pulmonary Disease: Review of Selected Guidelines: an official statement from the American Association of Cardiovascular and Pulmonary Rehabilitation. J Cardiopulm Rehabil Prev. 2016;36(2):75-83. DOI: 10.1097/HCR.0000000000000171
Clini EM, Crisafulli E. Exercise capacity as a pulmonary rehabilitation outcome. Respiration. 2009;77(2):121-8. DOI: 10.1159/000192773
Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, at al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13-64. DOI: 10.1164/rccm.201309-1634ST
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