Caracterización clínica y demográfica de pacientes colombianos con rinosinusitis crónica con poliposis nasal

Abstract

Introduction: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is associated with a high daily burden of symptoms and a significant impact on health-related quality of life (HRQoL) (HRQoL). To date, the clinical and demographic characteristics of Colombian patients with CRSwNP are unknown.

Objectives: The aim of this study is to present the baseline clinical and demographic characteristics of CRSwNP patients over the age of 18 enrolled in a Patient Support Program (PSP) prior to biologic treatment.

Methodology: Descriptive, cross-sectional study performed in a Colombian CRSwNP asthma PSP sponsored by Sanofi from Aug-2021 to Jul-2022. Data was collected from CRSwNP patients, prior to the start of Dupilumab treatment, who consented to the use of their data.  The following information was reported: Age, reporting city, treating medical specialty, comorbidities, and persistence of treatment.

Results: 339 patients were included, 171 (50.4%) were women and 168 (49.6%) were men (Figure 1). The mean age at Dupilumab treatment initiation was 52.4 years. 62.8% began treatment during adulthood (26-59y), while 34.1% started at elderly (+60y) and 3.1% were young adults (18-25y). Most cases (29.7%) were included in Bogotá, followed by Antioquia (19%), Valle del Cauca (7.3%) and the remaining 44% nationwide (Figure 2).

Comorbidities were present in 67.1% of the patients, with diagnosis of allergic rhinitis, atopic dermatitis, asthma, and other non-type 2 inflammatory diseases (Figure 3). Nasal surgical history was present in 89.6% of the patients, most of them with one to three previous surgeries (Figure 4).

Continuous treatment was observed in 70.3% of patients for 6 to 12 months, in 21.3% for more than 12 months and in 8.4% for less than 6 months. The most frequently treating medical specialty was otorhinolaryngology (79,6%), followed by allergology (16%) and other medical professionals (4.4%).

Conclusions:

• There is concordance with the literature on a higher presentation of the disease in women than in men.
• There is a large proportion of patients with nasal surgical history and type 2 inflammatory comorbidities by the moment of biologic treatment initiation.
• The care and identification of CRSwNP colombian patients is mainly provided by otorhinolaryngologists, followed by allergologists.