Inflammaging en pacientes con Fibrosis pulmonar idiopática (FPI).

Abstract

Background: Chronic lung pathologies represent a mortality burden on older adults. Specifically, idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial disease with a prevalence that increases linearly with age. Immune aging has been characterized by increased circulating proinflammatory cytokines that can facilitate pathological remodeling and tissue fibrosis. In this context, there can be a connection between the cytokine profile and diseases such as IPF.

Aim: To identify proinflammatory cytokines in the plasma of patients with IPF residing in the Bogotá area.

Materials and methods: We took Peripheral blood samples from healthy adults and patients over 60 years of age with a confirmed diagnosis of IPF through biopsy or clinical criteria. We measure proinflammatory cytokines in plasma using CBA. This study received approval from the ethics and research committee of the Fundación Neumologica Colombiana.

Results: Patients with IPF exhibited increased cytokines such as IL-4, INFy, and IL-6 compared to healthy older adults.

Conclusion: Inflammatory disease has been associated with the development and coexistence of multiple chronic non-communicable diseases that have a higher incidence after 65 years old. The involvement of adaptive immunity in the pathogenesis of IPF has been described as an imbalance in the Th1/Th2 lymphocyte response. Further studies are required to identify additional markers of immunosenescence that correlate with IPF.