Keywords
Allergen
Latam
Abstract
Background: Tree tomato (Solanum betaceum or Cyphomandra betaceae) or tamarillo belongs to the Solanaceae family and is widely consumed in Latin American countries.
Case report: We report the case of a 43-year-old male from Ecuador who suffered two systemic anaphylaxis after drinking tamarillo juice, with previous tolerance to tamarillo on several occasions. Allergology study showed positivity in prick-prick to tamarillo peel and pulp and negativity to other types. SDS-PAGE immunoblotting with peel-pulp and Western Blot showed multiple bands between 14-75 kDa in tamarillo peel and 11-75 kDa in pulp. ELISA inhibition showed that tamarillo only inhibited itself.
Conclusions: Given the results and tolerance to other types of tomato, we believe that the causative protein could be selective, so we report the first case of primary sensitivity to Solanum betaceum (tamarillo).
Keywords: Tree tomato; Tamarillo; Solanum betaceum; Allergy; Latin America; Ecuador.
References
1. Włodarczyk K, Smolińska B, Majak I. Tomato Allergy: The Characterization of the Selected Allergens and Antioxidants of Tomato (Solanum lycopersicum). A Review. Antioxidants (Basel) 2022; 11 (4): 644. doi: 10.3390/antiox11040644
2. Vidal C, González-Quintela A, Rodriguez V, Armisén M, et al. Anaphylaxis to Cyphomandra betacea Sendth (tamarillo) in an obeche wood (Triplochiton scleroxylon) allergic patient. Ann Allergy Asthma Immunol 2006; 96 (6): 870-3. doi: 10.1016/S1081-1206(10)61352-X
3. Prohens J, Nuez F. The Tamarillo (Cyphomandra betacea). Smal Fruits Rev 2010; 1 (2): 43-68. https://doi.org/10.1300/J301v01n02_06
4. Tiwari R, Wolber FM. Identification of Tamarillo (Cyphomandra betacea) Allergens. J Allergy Clin Immunol 2011; 127 (2): AB110. https://www.jacionline.org/article/S0091-6749(10)02384-5/fulltext
5. Moreno-Miranda, et al. Cadena de valor en tomate de árbol (Solanum lycopersicum) en Ecuador. Agron Mesoam 2020; 31 (1): 13-29. http://dx.doi.org/10.15517/am.v31i1.36887
6. Reche M, Pascual CY, Vicente J, Caballero T, et al. Tomato allergy in children and young adults: cross-reactivity with latex and potato. Allergy 2001; 56 (12): 1197-1201. doi: 10.1034/j.1398-9995.2001.00279.x
7. Asero R, Mistrello G, Amato S. Anaphylaxis caused by tomato lipid transfer protein. Eur Ann Allergy Clin Immunol 2011; 43 (4): 125-126. http://www.eurannallergyimm.com/cont/journals-articles/241/volume-anaphylaxis-caused-tomato-lipid-transfer-638allasp1.pdf
8. Tomás-Pérez M, Hernández-Martín I, Fernández de Alba-Porcel I, Pagola MJ, et al. Alergia a vegetales pertenecientes a la familia de las solanáceas. Rev Alerg Méx 2019; 66 (3): 322-238. https://doi.org/10.29262/ram.v66i3.608
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