Cereal-dependent exercise-induced anaphylaxis

Abstract

Wheat-dependent exercise-induced anaphylaxis (WDEIA) is increasing. In vitro test such as ω-5-gliadin levels are useful in the diagnosis, while oral single blind challenge tests (OCT) with wheat plus exercise continuous being the gold standard diagnostic method. This paper reports the case of a 38-year-old woman, with several episodes of anaphylaxis after eating different foods and doing exercise after ingestion. An allergy study was performed with positive skin prick tests for wheat, barley and rye. Total IgE 238.0KU/L, positive specific IgE (>100KU/L) to wheat, barley and rye, and negative to rTri-a-19 ω-5 gliadin. OCT with bread and exercise was positive. In this case of wheat-dependent exercise-induced anaphylaxis (WDEIA) with negative serum specific IgE to ω-5 gliadin, negative results with γ, α, β y ω-gliadin doesn’t exclude the diagnosis of WDEIA.