Supplementary Files
Keywords
The Latin American Society of Allergy
Asthma
and Immunology (SLAAI) presents a document about the use of immunotherapy (IT) in Latin America
where administration patterns
indications and contraindications
effects on health
adverse events
Abstract
Background: The Latin American Society of Allergy, Asthma, and Immunology (SLAAI) presents a document about the use of immunotherapy (IT) in Latin America, where administration patterns, indications and contraindications, effects on health, adverse events and socioeconomic impact are reviewed.
Objective: To review publications analyzing the use of IT in Latin America.
Methods: A literature review was carried out in order to identify works addressing IT in Latin America. This review was focused on practical scientific information available on IT in the region, and a parallel comparison was made with practices observed in the United States and European countries.
Results: Of the 21 Latin American countries included, only 9 had original articles meeting the selection criteria; a total of 82 articles were selected, most of them from Brazil and Mexico. Most widely used allergenic extracts in Latin America tropical and subtropical regions were those of mites and pollen.
Conclusion: Although it is true that there are huge challenges for the future of IT in Latin America, studies on subcutaneous IT and sublingual IT are increasing, but most of them are retrospective and some have design bias, and more prospective studies are therefore required, using internationally validated scales for clinical evaluation.
References
Higgins JP, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. DOI: 10.1136/bmj.d5928
Rincón-Pérez C, Velarde-Domínguez T. Eficacia de la inmunoterapia para el tratamiento de la urticaria crónica (hiposensibilización rápida). Rev Sanid Milit Mex. 2001;55(5):190-193. Disponible en: http://www.medigraphic.com/pdfs/sanmil/sm-2001/sm015d.pdf
Guimarães-Junqueir-De-Queirós M, Oliveira-Silva DA, Alves R, Fukuhara-Chiba H, Soares-De-Amaral VB, De-Almeida KC, et al. Mite-specific immunotherapy using allergen and/or bacterial extracts in atopic patients in Brazil. J Investig Allergol Clin Immunol. 2008;18(2):84-92. Disponible en: http://www.jiaci.org/summary/vol18-issue2-num316
Queirós MG, Silva DA, Siman IL, Ynoue LH, Araújo NS, Pereira FL, et al. Modulation of mucosal/systemic antibody response after sublingual immunotherapy in mite-allergic children. Pediatr Allergy Immunol. 2013;24(8):752-761. DOI: 10.1111/pai.12163
Socci M, Slullitel P, Cortigiani L. 158 efficacy of immnunotherapy with an oral bacterial lysate and vitamin C in the primary prevention of acute respiratory tract infections in children. World Allergy Organ J. 2012;5(Suppl 2):S69. DOI: 10.1097/01.WOX.0000411915.12461.d7
Baena-Cagnani CE, Larenas-Linnemann D, Gómez M, Díaz SG, Solé D, Borges MS, et al. Allergy training and immunotherapy in Latin America: Results of a regional overview. Ann Allergy Asthma Immunol. 2013;111(5):415-419. DOI: 10.1016/j.anai.2013.08.011
Cardona R, Lopez E, Beltrán J, Sánchez J. Safety of immunotherapy in patients with rhinitis, asthma or atopic dermatitis using an ultra-rush buildup. A retrospective study. Allergol Immunopathol (Madr). 2014;42(2):90-95. DOI: 10.1016/j.aller.2012.07.005
Cox L, Larenas-Linnemann D, Lockey RF, Passalacqua G. Speaking the same language: The World Allergy Organization Subcutaneous Immunotherapy Systemic Reaction Grading System. J Allergy Clin Immunol. 2010;125(3):569-574. DOI: 10.1016/j.jaci.2009.10.060
Santos N, Pereira AM, Silva R, Torres-Da-Costa J, Plácido JL. Characterisation of systemic reactions to subcutaneous immunotherapy with airborne allergens and classification according to WAO 2010. Allergol Immunopathol (Madr). 2015;43(1):25-31. DOI: 10.1016/j.aller.2013.10.006
Cardona-Villa R, Chinchilla-Mejía C, Ramirez-Giraldo R, Olivares-Gómez MMO, Calvo V, Maspero J. Poster 2010: A study assessing the safety and efficacy of subcutaneous immunotherapy with a dust mite vaccine with the adjuvant L-tyrosine in a highly sensitized population in a Latin-American city. World Allergy Organ J. 2014;7(Suppl 1):P22. DOI: 10.1186/1939-4551-7-S1-P22
Molina-Sáenz MM, Villa-Arango AM, Cardona-Villa R. Safety of subcutaneous immunotherapy with tyrosine-adsorbed house dust mite extracts in patients with allergic disease. Rev Alerg Mex. 2017;64(1):52-65. DOI: 10.29262/ram.v64i1.233
Castelblanco-Arango I, Gómez-Pineda PA, Cardona-Villa R. Determinación de la seguridad de la inmunoterapia subcutánea con extractos polimerizados de dermatophagoides farinae, dermatophagoides pteronyssinus y blomia tropicalis administrada en pacientes con enfermedad alérgica. Med Lab. 2016;22(7):365-380. Disponible en: http://www.edimeco.com/phocadownloadpap/2016/Resumen%20Inmunoterapia.pdf
Morales-Menéndez M, Fernández-Pérez R, Morales-Menéndez M, Pérez-Fabelo M. Comportamiento del tratamiento con vacunas antialérgicas en pacientes alérgicos. AMC. 2010;14(3):1-15. Disponible en: http://scielo.sld.cu/pdf/amc/v14n3/amc030310.pdf
Sosa-Jiménez G, López-García A, Galindo-García JA, Paz-Martínez D, Carrillo-Tamez R, Papaqui-Tapia S. Incidence of adverse reactions to immunotherapy in allergic patients at Puebla University Hospital. Rev Alerg Mex. 1998;45(6):147-9. Disponible en: http://scielo.sld.cu/pdf/amc/v14n3/amc030310.pdf
Rodríguez-Santos O. Sublingual immunotherapy in allergic rhinitis and asthma in 2-5 year-old children sensitized to mites. Rev Alerg Mex. 2008;55(2):71-75.
Rodríguez-Santos O, Reyes-Almaguer M. Eficacia y seguridad de la inmunoterapia sublingual en niños de 6 a 24 meses de edad con rinitis y asma bronquial sensibilizados a los ácaros domésticos. Vaccimonitor. 2015;24(2):86-92. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1025-028X2015000200005&lng=es&nrm=iso&tlng=es
Rodríguez N, Ambriz M, Pizarro U. Reacciones sistémicas no fatales por inmunoterapia y pruebas cutáneas. Rev Alerg Mex. 2002;49(3):69-73.
Rodríguez-Pérez N, Ambriz-Moreno MJ. Safety of immunotherapy and skin tests with allergens in children younger than five years. Rev Alerg Mex. 2006;53(2):47-51.
Avila-Castañón L, Lerma-Ortiz L, Velázquez-Armenta Y, Del Río-Navarro BE, Sienra-Monge JJ. Adverse reactions to immunotherapy in pediatric patients. Rev Alerg Mex. 2003;50(5):182-186.
González-Díaz SN, De la Rosa-López JH, Arias-Cruz A, Macías-Weinmann A, Herrera-Castro D, Rodríguez-Ortíz P, et al. Related systemic reactions to allergen immunotherapy in Monterrey, Mexico. Rev Alerg Mex. 2011;58(2):79-86.
Rodríguez-Pérez N, Ambriz-Moreno M, Canonica GW, Penagos M. Frequency of acute systemic reactions in patients with allergic rhinitis and asthma treated with sublingual immunotherapy. Ann Allergy Asthma Immunol. 2008;101(3):304-310.
Larenas-Linnemann D, Rodríguez-Pérez N, Becerril M. Adverse reactions to skin tests and immunotherapy in the practice of Mexican allergologists. Rev Alerg Mex. 2008;55(2):62-70.
Moncayo-Coello CV, Rosas-Vargas MA, Del Río-Navarro BE, Lerma-Ortiz L, Velázquez-Armenta Y, Sienra-Monge JJ. Quality of life in children with allergic rhinitis before and after being treated with specific immunotherapy (cases and controls). Rev Alerg Mex. 2003;50(5):170-175.
Yepes-Núñez JJ, Gómez C, Espinoza Y, Cardona R. The impact of subcutaneous immunotherapy with dermatophagoides farinae and dermatophagoides pteronyssinus on the quality of life of patients with allergic rhinitis and asthma. Biomedica. 2014;34(2):282-290.
Solari JE, Loo J, Felices A, Casas J. Immunotherapy for patients with persistent allergic rhinitis unsatisfied with free chronic pharmacotherapy. Allergol Immunopathol (Madr). 2006;34(3):102-106.
Rodríguez-Santos O. Sublingual immunotherapy with allergenic extract of dermatophagoides pteronyssinus in asthmatic children. Rev Alerg Mex. 2004;51(5):177-180.
Rodríguez-Medina R, López-Durán JL, Gasca-Bauza MR, Cortéz-González E, Zamora-Limón E. Effect of immunotherapy with allergens in asthmatic children with integral treatment. Rev Alerg Mex. 2000;47(5):162-165.
Skrie V. Inmunoterapia con alergenos en niños menores de 5 años con asma bronquial. Doctoral Thesis, National University of Cordoba, Faculty of Medical Sciences. 2009.
Baptistella E, Maniglia S, Malucelli DA, Rispoli D, Pruner-DeSilva T, Tsuru FM, et al. Allergen-specific immunotherapy in patients 55 years and older: Results and review of literature. Int Arch Otorhinolaryngol. 2013;17(4):375-379. DOI: 10.1055/s-0033-1353138
Sánchez J, Restrepo M., Diez S, Cardona R. Comparación del efecto clínico de la inmunoterapia en pacientes con asma alérgica según la edad y el patrón de sensibilización. Alerg Asma Inmunol Pediatr. 2014;23(1):77-85.
Barrera T. Efectos de la Inmunoterapia sobre la hiperreactividad bronquial de pacientes con rinitis alérgica. Tesis de doctorado, Universidad Nacional de Córdoba, Facultad de Ciencias Médicas. 2009.
Santos S, Chaves-Loureiro C, Lemos S, Pinheiro JA. Alergia a veneno de himenópteros na criança. Scientia Medica (Porto Alegre). 2012;22(4):203-207.
Guzmán MA, Salinas LJ, Toche PP, Marinovic MMA, Gallardo OAM. Immunotherapy against hymenoptera venom: Report of ten patients. Rev Med Chil. 2007;135(12):1566-1571. DOI: S0034-98872007001200010
Sánchez-Caraballo JM, Cardona-Villa R. Clinical and immunological changes of immunotherapy in patients with atopic dermatitis: Randomized controlled trial. ISRN Allergy. 2012;2012:183983. DOI: 10.5402/2012/183983
Sánchez J, Cardona R. Effect of immunotherapy on basophil activation induced by allergens in patients with atopic dermatitis. Rev Alerg Mex. 2014;61(3):168-177.
López-Piedrahita E, Sánchez-Caraballo JM, Ramírez-Girado RH, Cardona-Villa R. Effectiveness of allergen immunotherapy in patients with vernal keratoconjuctivitis. Rev Alerg Mex. 2013;60(1):11-16.
Núñez JA, Cuesta U. Local conjunctival immunotherapy: The effect of dermatophagoides pteronyssinus local conjunctival immunotherapy on conjunctival provocation test in patients with allergic conjunctivitis. Allergol Immunopathol (Madr). 2000;28(6):301-306.
Medeiros M, Lyra A, Santos H, Mendes C, Almeida K, Silva D. Eficácia clínica da imunoterapia nasal comparada com imunoterapia sublingual em pacientes com rinite alérgica. Rev Bras Alerg Imunopatol. 2009;32(1):13-17.
Zavadniak AF, Rosário-Filho NA, Arruda LK, Morato-Castro FF, Solé D, Aun WT, et al. Verificação da potência de extratos alergênicos comerciais de dermatophagoides pteronyssinus para imunoterapia. Rev Bras Alerg Imunopatol. 2004;27(2):46-54. Disponible en: http://www.asbai.org.br/revistas/vol272/verificacao.pdf
Rosas-Alvarado A, López-López JR. Basis to modify the immunotherapy regimen at the Allergy Service, General Hospital of Mexico. Rev Alerg Mex. 2010;57(4):107-111.
Siman IL, De-Aquino LM, Ynoue LH, Miranda JS, Pajuaba AC, Cunha-Júnior JP, et al. Allergen-specific IgG antibodies purified from mite-allergic patients sera block the IgE recognition of dermatophagoides pteronyssinus antigens: An in vitro study. Clin Dev Immunol. 2013;2013:657424. DOI: 10.1155/2013/657424
Velázquez BL, Segura DL, Barbosa DE, Vázquez MI, Tapia JG, Altamirano SC, et al. Determination of interleukins and IgG4 in patients with allergic rhinitis with and without immunotherapy. Rev Alerg Mex. 2004;51(4):139-144.
Yang AC, Arruda LK, Santos ABR, Barbosa MCR, Chapman MD, Castro K, et al. Cross-reactivity Between Mite And Shrimp: The Effect Of Immunotherapy With Dust Mite Extract. J Allergy Clin Immunol. 2009;125(2):AB35. DOI: 10.1016/j.jaci.2009.12.168
Almeida-Castro R, Santos-Souza K, Yang A, Fernandes-Morato-Castro F, Galvão CES, Mari A, et al. New manioc allergens and successful oral immunotherapy in a Brazilian allergic patient. World Allergy Organ J. 2015;8(Suppl 1):A181. DOI: 10.1186/1939-4551-8-S1-A181
Mouchián D, Albónico J, Potenza M, Bignone M, Rodríguez S, Irañeta S. Utilidad de los péptidos 33 y 38 de Lolium perenne en la inmunoterapia de la rinitis polínica. Rev Asoc Med Argent. 2014;127(1):8-19.
Fonseca DM, Wowk PF, Paula MO, Gembre AF, Baruffi MD, Fermino ML, et al. Requirement of MyD88 and Fas pathways for the efficacy of allergen-free immunotherapy. Allergy. 2015;70(3):275-284. DOI: 10.1111/all.12555
Escobar A, Aguirre A, Guzmán MA, González R, Catalán D, Acuña-Castillo C, et al. Tolerogenic dendritic cells derived from donors with natural rubber latex allergy modulate allergen-specific T-cell responses and IgE production. PLoS One. 2014;9(1):e85930. DOI: 10.1371/journal.pone.0085930
Smaldini PL, Orsini-Delgado ML, Fossati CA, Docena GH. Orally-induced intestinal CD4+ CD25+ FoxP3+ Treg controlled undesired responses towards oral antigens and effectively dampened food allergic reactions. PLoS One. 2015;10(10):e0141116. DOI: 10.1371/journal.pone.0141116
Sato MN, Carvalho AF, Silva AO, MacIel M, Fusaro AE, Duarte AJ. Low dose of orally administered antigen down-regulates the T helper type 2-response in a murine model of dust mite hypersensitivity. Immunology. 1999;98(3):338-344. DOI: 10.1046/j.1365-2567.1999.00869.x
Ruiz FJ, Jiménez A, Cocoletzi J, Durán E. Compliance with and abandonment of immunotherapy. Rev Alerg Mex. 1997;44(2):42-44.
Sánchez J. Adherence to allergen immunotherapy improves when patients choose the route of administration: subcutaneous or sublingual. Allergol Immunopathol (Madr). 2015;43(5):436-441. DOI: 10.1016/j.aller.2014.04.011
Gallardo-Martínez G, Arias-Cruz A, González-Díaz SN, Galindo-Rodríguez G. Costs due to asthma medical care in a group of children from northeastern Mexico. Rev Alerg Mex. 2007;54(3):82-85.
Sánchez J, Sánchez A, Cardona R. Economic consequences in real life of allergen immunotherapy in asthma, rhinitis and dermatitis. Rev Alerg Mex. 2016;63(4):323-333. DOI: 10.29262/ram.v63i4.238
Sanchez-Caraballo J, Diez-Zuluaga S, Cardona-Villa R. Sensibilización a aeroalergenos en pacientes alérgicos de Medellín, Colombia. Rev Alerg Mex. 2012;59(3):139-147.
Forno E, Gogna M, Cepeda A, Yañez A, Solé D, Cooper, et al. Asthma in Latin America. Thorax. 2015;70(9):898-905. DOI: 10.1136/thoraxjnl-2015-207199
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright (c) 2018 Revista Alergia México