Keywords
proteins of cow’s milk
How to Cite
Plaudit
Abstract
Background: The cow’s milk protein allergy is the most common food allergy among children under two years and is associated with other atopic diseases.
Objective: To evaluate cow’s milk protein allergy frequency in patients sensitized to them, attended at the consultation of Immunology and Allergy in the Hospital Infantil de México Federico Gómez, and its association with other atopic diseases.
Material and method: A cross-sectional, analytical and descriptive study that reviewed medical records of patients aged 0-19 years, attended at the consultation of Immunology and Allergy in the Hospital Infantil de México Federico Gómez, from January 2010 to January 2013, sensitized to the cow’s milk protein by in vitro or in vivo studies, mediated or not by IgE, to determine its association with other atopic diseases during the course of their clinical evolution.
Results: We included 252 patients with symptoms suggestive of cow’s milk protein allergy, which was diagnosed only in 15.1% by oral challenge. In relation to respiratory symptoms, about two-thirds of patients had rhinorrhea, nasal obstruction and nasal itching. Regarding gastrointestinal symptoms, about a third had abdominal pain, diarrhea and abdominal distension, being statistically significant. The most common dermatologic symptom, statistically significant, was xerosis. The most frequently associated atopic diseases were food allergy (76.3%), allergic rhinitis (65.8%), asthma (47.4%) and atopic dermatitis (23%).
Conclusions: The cow’s milk protein allergy can be associated with other atopic diseases, such as allergy to other foods, allergic rhinitis, asthma and atopic dermatitis.
References
Cervantes R, Sánchez M, Bacarreza D, Montijo E, et al. Actualidades en alergia a la proteína de la leche de vaca. Rev Enferm Infecc Pediatr 2007;21:52-59.
Ávila-Castañón L, Hidalgo-Castro ME, Del Río-Navarro B, Sienra-Monge J. Alergia a la proteína de la leche de vaca. Revista Alergia México 2005;52:206-212.
Brill H. Clinical review. Approach to milk protein allergy in infants. Can Fam Phisician 2008;54:1258-1264.
Cadena-León JF, Cer van t es R, Mon ti jo-Barrios E, Hernández-Baustista V, et al. Métodos diagnósticos de alergia a la proteína de la leche de vaca. Revisión cualitativa de la literatura. Alergia e Inmunol Pediatr 2009;18:113-120.
Tikkanen S, Kokkonen J, Juntti H, Niinimäki A. Status with children with cow’s milk allergy in infancy by 10 years of age. Acta Pediatr 2000;89:1174-1180.
Orsi M, Fernández A, Follett F, Marchisone S, et al. Alergia a la proteína de la leche de vaca. Propuesta de guía para el manejo de los niños con alergia a la proteína de la leche de vaca. Arch Argent Pediatr 2009;107:459-473.
Lannero E, Wickman M, Van Hage M, Bergstrom A, et al.}Exposure to environmental tobacco smoke and sensitisation in children. Thorax 2008;63:172-176.
Venter C, Pereira B, Grundy J, Clayton CB, et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol 2006;117:1118-1124.
Scherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2010;125:116-125.
Cochrane S, Beyer K, Clausen M, Wjst M, et al. Factors influencing the incidence and prevalence of food allergy. Allergy 2009;64:1246-1255.
Greer F, Sicherer SH, Burks AW, American Academy of Pediatrics Committee on Nutrition, American Academy of Pediatrics Section on Allergy and Immunology. Effects of early nutritional interventions on the development of atopic disease in infants and children: The role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 2008;121:183-191.
Arenas R. Atlas de Dermatología. Diagnóstico y tratamiento. 3ª edición. México McGrawHill 2005;76-78.
Clein NW. Cow’s milk protein allergy in infants and children. Int Arch Allergy 1958;13:245-256.
Jacobson O, Lindberg T. A prospective study of cow’s milk protein intolerance in Swedish infants. Acta Pediatr Scand 1979;68:853-859.
Hill DJ, Davidson GP, Cameron DJ, Barnes GL. The spectrum of cow’s milk allergy in childhood. Clinical gastroenterological and immunological studies. Acta Paediatr Scand 1979;68:847-852.
Bishop JM, Hill DJ, Hosking CS. Natural history of cow milk allergy: clinical outcome. J Pediatr 1990;116:862-867.
Host A, Halken S. A prospective study of cow milk allergy in Danish infants during the first 3 years of life. Clinical course in relation to clinical and immunological type of hypersensitivity reaction. Allergy 1990;45:587-596.
Sprikkelman AB. Cow’s milk protein allergy or intolerance: a prospective follow-up study. Thesis. The Netherlands. University of Groningen 1999.
Hill DJ, Banniester DG, Hosking CS, Kemp AS. Cow milk allergy within the spectrum of atopic disorders. Clin Exp Allergy 1994;24:1137-1143.
Host A, Halken S, Jacobsen HP, Estmann A, et al. The natural course of cow’s milk protein allergy/intolerance. J Allergy Clin Immunol 1997;99:490.
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