Oral lichen planus. Case report and literature review
PDF (Spanish)
PubMed

Supplementary Files

XML (Spanish)

Keywords

Oral lichen planus
Dermatological autoimmune disease
Malignization potential

Abstract

Background: Oral lichen planus is a chronic inflammatory skin disease of autoimmune nature, with infiltration of T lymphocytes that destroy the basal stratum, which causes white striae, erosions, ulcers and breaks in epithelial continuity.

Case report: 54-year-old woman with multiple reticular and erosive lesions in the region of the buccal mucosa and lateral borders of the tongue, as well as desquamative gingivitis. Treatment with mometasone was started thrice daily for 20 days and intermittently with miconazole gel to prevent iatrogenic mycosis by the corticosteroid. The patient was examined at 20 days, after which 80 % improvement of the lesions that had central ulcerations was observed, which allowed the ingestion of food and fluids without pain and improved the quality of life.

Conclusions: In autoimmune diseases, clinical-histopathological correlation is important for a definitive diagnosis to be established. Clinical follow-up of these patients should be carried out in the long term, in order to achieve remission of the lesions, control of the disease and avoid future complications.

PDF (Spanish)
PubMed

References

Neville BW, Dam DD, Allen CM, Bouquot JE. Oral & maxillofacial pathology. EE. UU.: Saunders Elsevier; 2009.

Bascones-Ilundain C, González-Moles MA, Carrillo-De Albornoz A, Bascones-Martínez A. Liquen plano oral (I). Aspectos clínicos, etiopatogénicos y epidemiológicos. Av Odontoestomatol. 2006;22(1):11-19. Disponible en: http://scielo.isciii.es/pdf/odonto/v22n1/original1.pdf

Blanco-Carrión A, Gándara-Rey JM, Rodríguez-Núñez A, García-García A, Rodríguez-Núñez I. Alteraciones bioquímicas y su correlación clínica con el liquen plano oral. Medicina Oral. 2000;5(4):238-249.

González-Moles MA, Rodríguez-Arcilla A, Ruiz-Ávila I, Morales-García P. Liquen plano oral. RCOE. 2000;5:255-269.

Valeron F, Caballero M, Caballero R. Liquen plano oral. Espejo Clínico. 1999;0:6-11.

Bascones A, Seoane JM, Aguado A, Suárez-Quintanilla JM. Cáncer y precáncer oral. Bases clínico-quirúrgicas y moleculares. España: Ediciones Avances; 2003.

Hirota M, Ito T, Okudela K, Kawabe R, Yazawa T, Hayashi H, et al. Cell proliferation activity and expression of cell cycle regulatory proteins in oral lichen planus. J Oral Pathol Med. 2002;31(4):204-212. DOI: 10.1034/j.1600-0714.2002.310403.x

White FH, Jin Y, Yang L. Quantitative cellular and nuclear volumetric alterations in epithelium from lichen planus lesions of human buccal mucosa. J Oral Pathol Med. 1994;23(5):205-208. DOI: 10.1111/j.1600-0714.1994.tb01114.x

Carrozo M, Gandolfo S. The management of oral lichen planus. 1999;5:196-205. DOI: 10.1111/j.1601-0825.1999.tb00301.x

Micó JM, Delgado E, Berini L, Cosme G. Liquen plano bucal: diagnóstico y tratamiento. Quintessence. 2001;4(4):247-256.

Bloor BK, Malik FR, Odell EW, Morgan PR. Quantitative assessment of apoptosis in oral lichen planus. Oral Surg Oral Med Oral Pathol Radiol Endod. 1999;88(2):187-195. DOI: 10.1016/S1079-2104(99)70116-2

Tobón-Arroyaye SI, Villegas-Acosta FA, Ruiz-Restrepo SM, Vieco-Durán M, Restrepo-Misas M, Londoño-López ML. Expression of caspase-3 and structural changes associated with apoptotic cell death of keratincytes in oral lichen planus. Oral Dis. 2004;10(3):173-178. DOI: 10.1046/j.1601-0825.2003.00998.x

Dekker NP, Lozada-Nür F, Lagenaur LA, MacPhail LA, Blom CY, Regezi JA. Apoptosis-associated markers in oral lichen planus. J Oral Pathol Med. 1997;26(4):170-175. DOI: 10.1111/j.1600-0714.1997.tb00453.x

Neppelberg E, Johannessen AC, Jonsson R. Apoptosis in oral lichen planus. Eur J Oral Sci. 2001;109(5):361-364. DOI: 10.1034/j.1600-0722.2001.00081.x

Walsh LJ, Savage NW, Ishiit T, Symour GJ. Inmunopathogenesis of oral lichen planus. J Oral Pathol Med. 1990;19(9):389-396. DOI: 10.1111/j.1600-0714.1990.tb00866.x

Luis-Montoya P, Vega-Memíje ME. Liquen plano en niños. Dermatol Rev Mex. 2013;57:178-184.

Luis-Montoya P, Cortés-Franco R, Vega-Memije ME. Liquen plano e infección por virus de hepatitis C. ¿Existe una asociación? Gac Med Mex. 2005;141(1):23-25. Disponible en: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0016-38132005000100004

Cerero-Lapiedra R, García-Núñez JA, García-Pola MJ. Liquen plano oral. RCOE. 1997;2:643-660.

Valente G, Pagano M, Carrozzo M, Carbone M, Bobba V, Palestra G, et al. Sequential immunohstochemical p53 expression in biopses of oral lichen planus undergoing malignant evolution. J Oral Pathol Med. 2001;30(3):135-140. DOI: 10.1034/j.1600-0714.2001.300302.x

Zhou XJ, Sugerman PB, Savage NW, Walsh LJ, Seymour G. Intraepithelial CD8+ T cells and basement membrane disruption in oral lichen planus. J Oral Pathol Med. 2002;31(1):23-27. DOI: 10.1046/j.0904-2512.2001.10063.x

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2018 Revista Alergia México

Downloads

Download data is not yet available.