Supplementary Files
Keywords
Allergen
Sensitization
Allergy
Atopy
How to Cite
Plaudit
Abstract
Background: Mites are the main cause of atopy and allergies in the Tropical region. It is necessary to know the phylogenetic relationship of their allergenic proteins in order to determine the best combination of extracts for its use at the clinic.
Objective: To assess the phylogenetic relationship between the main allergenic proteins of mites.
Methods: Groups 1, 2 and 5 of Glyciphagidae, Pyroglyphidae, Chortoglyphidae and Acaridae families were compared according to the sequence of mRNA and amino acids with the validated sequences of the National Center for Biotechnology Information and through bioinformatic alignment analyses for the construction of the trees, the method of neighbor-joining, with bootstrap support with 500 replications, was used as a measure of reliability and robustness.
Results: 15% to 87% of identity was found in the three groups of allergens; the highest was between Der p2 and Der f2 (86.98%) and, the lowest, between Der f 5 and Gly d 5 (17.87%) Piroglyphidae showed the highest relationship between the species. The longest branching distance was identified in Glicyphagidae, especially in Blomia tropicalis.
Conclusion: Some allergenic proteins have a high identity between the different species of mites, unlike Blomia tropicalis. These results can be taken into consideration when the diagnosis and treatment of allergic diseases is being defined.
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