Supplementary Files
Keywords
Common variable immunodeficiency
Intravenous immunoglobulin
Pneumonia
Abstract
Background: Common Variable Immunodeficiency (CVID) is the most frequent type of severe primary immunodeficiency (PID). Clinical manifestations of CVID occur at any age; nevertheless, they are more frequent between the age of 6 and 10 years, and between the age of 20 and 40 years. In medical literature, there are hardly any diagnostic reports on CVID after 50 years of age.
Clinical case: A 58-year-old man with a clinical history of repeated infections since the age of 35. The tests showed a decrease in IgG, IgA, and specific antibodies, without any other causes of hypogammaglobulinemia. The CVID diagnosis was made and the patient received treatment with human immunoglobulin replacement and a reinforcement of personal and environmental hygiene. The patient stopped presenting repeated infections.
Conclusion: Diagnoses made after the age of 50, although they’re late, they are fundamental to the recovery of the patient. In the referred case, replacement with human immunoglobulin allowed an improvement in the quality of life.
References
Bonilla FA, Barlan I, Chapel H, Costa-Carvalho BT, Cunnigham-Rundles C, de la Morena MT, et al. International Consensus Document (ICON): common variable immunodeficiency disorders. J Allergy Clin Immunol Pract. 2016;4(1):38-59. DOI: 10.1016/j.jaip.2015.07.025
do Amor-Divino PH, de Carvalho-Basilio JH, Alves-Fabbri RM, Bastos-Polônio I, Carvalho-Neves-Forte W. Bronquiectasia por imunodeficiência comum variável. J Bras Pneumol. 2015;41(5):482-484. DOI: 10.1590/S1806-37132015000000095
Forte WCN. Imunodeficiências primárias. En: Forte WCN. Imunologia do básico ao aplicado. Brasil: Atheneu, 2015.
Goudouris ES, Silva AMR, Ouricuri AL, Grumach AS, Condino-Neto A, Costa-Carvalho BT, et al. II Brazilian Consensus on the use of human immunoglobulin in patients with primary immunodeficiencies. Einsten (São Paulo). 2017;15(1):1-16. DOI: 10.1590/S1679-45082017AE3844
de Oliveira-Serra FA, Mosca T, Santos de-Menezes MC, Carvalho-Neves-Forte W. Manifestaciones clínicas de la deficiencia de IgA. Rev Alerg Mex. 2017;64(1):34-39. Disponible en: http://revistaalergia.mx/ojs/index.php/ram/article/view/216/436
European Society for immunodeficiency. Working definitions for clinical diagnosis of PID. Italia: European Society for immunodeficiency; 2018. Disponible en: https://esid.org
Brazilian Group for Immunodeficiency. Os 10 sinais de alerta para imunodeficiência primária. Brasil: Brazilian Group for Immunodeficiency; 2019. Disponible en: http://www.bragid.org.br
Picard C, Al-Herz W, Bousfiha A, Casanova JL, Chatila T, Conley ME, et al. Primary immunodeficiency diseases: an update on the classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015. J Clin Immunol. 2015;35(8):696-726. DOI: 10.1007/s10875-015-0201-1
Resnick ES, Moshier EL, Godbold JH, Cunningham-Rundles C. Morbidity and mortality in common variable immune deficiency over 4 decades. Blood. 2012;119(7):1650-1657. DOI: 10.1182/blood-2011-09-377945
Beppu-Kazue AP, Melardi-Warchavchik J, Reche-Rodrigues-Gaudino V, Colella-dos Santos M, Santos-de Menezes MC, Carvalho-Neves-Forte W. Pneumonias em imunodeficiência comum variável após mudança de ambiente físico. Braz J Allergy Immunol. 2015;3:93-98. DOI: 10.5935/2318-5015.20150019
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