Abstract
The concepts of endotype and phenotype have been introduced in the past few years with the purpose of identifying the different variants of asthma in children and adults by the interaction of epigenetic factors, such as genotype, environmental factors, and not inherited factors. All these factors participate in the onset and progression of asthma, as well as environmental allergens, which are the cause of asthma in most children and teenagers. The latest onset may be induced by the characteristics of the environment, as happens in most adults (occupational asthma). In a review of a hundred medical records of children with and without a family history, and of a group of patients in whom high IgE levels were not detected, clear differences were observed in terms of the age of onset and other characteristics, although the sensitization to allergens was very similar in those three groups (Dermatophagoides mites).
References
Juvenal GJ. Epigenética: vieja palabra, nuevos conceptos. Rev Argent Endocrinol Metab. 2014;51(2):66-74. Disponible en: http://www.raem.org.ar/numeros/2014-vol51/numero-02/66-74-endo2-5-juvenal-a.pdf
Muñoz-López F. Meaning of endotype-phenotipe in pediatric respiratory pathology. Intech Open; 2018. Disponible en: https://www.intechopen.com/books/asthma-diagnosis-and-management-approach-based-on-phenotype-and-endotype/meaning-of-endotype-phenotype-in-pediatric-respiratory-pathology
Terada T, Kawata R. Early intervention is important to prevent sensitization to new allergens. Med Sci (Basel). 2018;6(4):114. DOI: 10.3390/medsci6040114
Martín-Mateos, MA, Martorell A, Sociedad Española de Inmunología Clínica y Alergología Pediátrica. Estado actual y expectativas de futuro de la inmunoterapia con alérgenos en el asma. An Pediatr. 2012;76(4):181-183. DOI: 10.1016/j.anpedi.2012.01.011
Muñoz-López F. Intensity of bronchial hyperresponsiveness and asthma relapse risk in the young adult. Allergol Immunophatol (Madr). 2007;35(2):66-70. DOI: 10.1157/13101340
Lötvall J, Akdis CA, Bacharier LB, Bjerrmer L, Casale TB, Custovic A, et al. Asthma endotypes; a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011;127(2):355-360. DOI: 10.1016/j.jaci.2010.11.037
Lin C-Y. Endotypes of asthma in children. J Pediatric Resp Dis. 2014;10:51-58. Disponible en: https://pdfs.semanticscholar.org/6099/67c89b7de8b7e2625edc5ca6b6fda4b7f633.pdf
Belgrave D, Henderson J, Simpson A, Buchan I, Bishop C, Custovic A, et al. Disaggregating asthma: big investigation versus big data. J Allergy Cin Immunol. 2017;139(2):400-407. DOI: 10.1016/j.jaci.2016.11.003
Mésidor M, Benedetti A, El-Zein M, Menzies D, Parent ME, Rlouseau MC. Asthma phenotypes based on health services use for allergic diseases in a province-wide birth cohort. Ann Allergy Asthma Immunol. 2019;122(1):50-57. DOI: 10.1016/j.anai.2018.09.453
Oksel C, Haider S, Fontanella S, Frainay C, Custovic A. Classification of pediatric asthma: from phenotype discovery to clinical practice. Front Pediatr. 2018;6:258. DOI: 103389/fped.2018.00258
Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy. 2010;40(8):1130-1141. DOI: 10.1111/j.1365-2222.2010.03541.x
Liu AH. Revisiting the hygiene hypothesis for allergy and asthma. J Allergy Clin Immunol. 2015;136(4):860-865. DOI: 10.1016/j.jaci.2015.08.012
Daley D. The evolution of the hygiene hypothesis: the role of early exposures to viruses and microbes and their relationship to asthma and allergic diseases. Curr Opin Allergy Clin Immunol. 2014;14(5):390-396. DOI: 10.1097/ACI.0000000000000101
Laremas-Linnemann D, Salas-Hernández J, Vázquez-García JC, Ortíz-Aldana I, Fernández Vega M, Del Río-Navarro BE, et al. Guía Mexicana del Asma 2017. Rev Alerg Mex. 2017;64(Supl 1):s11-s128. Disponible en: http://revistaalergia.mx/ojs/index.php/ram/article/view/272/406
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