Abstract
The traditional diagnosis of allergy by Prick tests and/or RAST offers very limited information about the real nature of allergic problems and of their clinical, therapeutic and prognostic implications. The diagnosis by allergic components (natural or recombinant) suppose a great qualitative step leading a great improving in the diagnosis and treatment of allergic patients, because its use with clinical history and other diagnostic in vivo or in vitro methods improve importantly the diagnostic accuracy.
References
Avenberg KM, Harper DS, Larsson BL. Footnotes on allergy. 2a ed. Uppsala: Pharmacia, 1980.
Blackley CH. Experimental researches on the causes and nature of catarrhus aestivus (hay-fever or hay-asthma). 1st ed. London: Baillière Tindall Cox; 1876.
Ferreira F, Wolf M, Wallner M. Molecular approach to allergy diagnosis and therapy. Yonsei Med J 2014;55:839852.
Ciardiello MA, Giangrieco I, Tuppo L, Tamburrini M, et al. Influence of the natural ripening stage, cold storage, and ethylene treatment on the protein and IgE-binding profiles of green and gold kiwi fruit extracts. J Agric Food Chem 2009;57:1565-1571.
Focke M, Marth K, Valenta R. Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 2009;39:429-436.
Nelson HS, Iklé D, Buchmeier A. Studies of allergen extract stability: the effects of dilution and mixing. J Allergy Clin Immunol 1996;98:382-388.
Aalberse JA, Meijer Y, Derksen N, van der Palen-Merkus T, et al. Moving from peanut extract to peanut components: towards validation of component-resolved IgE tests. Allergy 2013;68:748-756.
Allergome. Disponible en: http://www.allergome.org
Allergen Nomenclature Sub-Committee. Allergen IUIS Nomenclature. Disponoble en: http://www.allergen.org
Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, et al. A WAO ARIA GA2LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 2013;6:17.
Gadisseur R, Chapelle JP, Cavalier E. A new tool in the field of in-vitro diagnosis of allergy: preliminary results in the comparison of ImmunoCAP© 250 with the ImmunoCAP© ISAC. Clin Chem Lab Med 2011;49:277-280.
Melioli G, Bonifazi F, Bonini S, Maggi E, et al. The ImmunoCAP ISAC molecular allergology approach in adult multisensitized Italian patients with respiratory symptoms. Clin Biochem 2011;44:1005-1011.
Mattsson L, Lundgren T, Everberg H, Larsson H, et al. Prostatic kallikrein: a new major dog allergen. J Allergy Clin Immunol 2009;123:362-368.
Marth K, Focke-Tejkl M, Lupinek C, Valenta R, et al. Allergen peptides, recombinant allergens and hypoallergens for allergen-specific immunotherapy. Curr Treat Options Allergy 2014;1:91-106.
Manavski N, Peters U, Brettschneider R, Oldenburg M, et al. Cof a 1: identification, expression and immunoreactivity of the first coffee allergen. Int Arch Allergy Immunol 2012;159:235-242.
Metz-Favre C, Pauli G, Bessot JC, De Blay F. Molecular allergology in practice: an unusual case of LTP allergy. Eur Ann Allergy Clin Immunol 2011;43:193-195.
Armentia A, Herrero M, Martín-Armentia B, Rihs HP, et al. Molecular diagnosis in cannabis allergy. J allergy Clin Immunol Pract 2014;2:351-352.
Santos KS, Gadermaier G, Vejvar E, Arcuri HA, et al. Novel allergens from ancient foods: Man e 5 from manioc (Manihot esculenta Crantz) cross reacts with Hev b 5 from latex. Mol Nutr Food Res 2013;57:1100-1109.
Carnés J, Larramendi C de, Ferrer A, Huertas A, et al. Recently introduced foods as new allergenic sources: sensitisation to Goji berries (Lycium barbarum). Food Chem 2013;137:130-135.
Pahr S, Constantin C, Mari A, Scheiblhofer S, et al. Molecular characterization of wheat allergens specifically recognized by patients suffering from wheat-induced respiratory allergy. Clin Exp Allergy 2012;42:597-609.
Quirce S, Diaz-Perales A. Diagnosis and management of grain-induced asthma. Allergy Asthma Immunol Res 2013;5:348-356.
Mameri H, Denery-Papini S, Pietri M, Tranquet O, et al. Molecular and immunological characterization of wheat Serpin (Tri a 33). Mol Nutr Food Res 2012;56:1874-1883.
Hauser M, Roulias A, Ferreira F, Egger M. Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol 2010;6:1.
Cuesta-Herranz J, Lázaro M, Martínez A, Figueredo E, et al. Pollen allergy in peach-allergic patients: sensitization and cross-reactivity to taxonomically unrelated pollens. J Allergy Clin Immunol 1999;104:688-694.
Giangrieco I, Rafaiani C, Liso M, Palazzo P, et al. Allergens in allergy diagnosis: a glimpse at emerging new concepts and methodologies. Transl Med UniSa 2012;4:27-33.
Carnés J, Ferrer A, Fernández-Caldas E. Allergenicity of 10 different apple varieties. Ann Allergy Asthma Immunol 2006;96:564-570.
Egger M, Mutschlechner S, Wopfner N, Gadermaier G, et al. Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view. Allergy 2006;61:461-476.
Vejvar E, Himly M, Briza P, Eichhorn S, et al. Allergenic relevance of nonspecific lipid transfer proteins 2: Identification and characterization of Api g 6 from celery tuber as representative of a novel IgE-binding protein family. Mol Nutr Food Res 2013;57:2061-2070.
Hoffmann-Sommergruber K. Plant allergens and pathogenesis-related proteins. What do they have in common? Int Arch Allergy Immunol 2000;122:155-166.
Ebner C, Hoffmann-Sommergruber K, Breiteneder H. Plant food allergens homologous to pathogenesis-related proteins. Allergy 2001;56:43-44.
Ebner C, Hirschwehr R, Bauer L, Breiteneder H, et al. Identification of allergens in fruits and vegetables: IgE cross-reactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95:962-969.
Valenta R, Duchene M, Ebner C, Valent P, et al. Profilins constitute a novel family of functional plant pan-allergens. J Exp Med 1992;175:377-385.
Fritsch R, Ebner C, Kraft D. Allergenic crossreactivities. Pollens and vegetable foods. Clin Rev Allergy Immunol 1997;15:397-404.
Cuesta-Herranz J, Lázaro M, de las Heras M, Lluch M, et al. Peach allergy pattern: experience in 70 patients. Allergy 1998;53:78-82.
Van Winkle RC, Chang C. The biochemical basis and clinical evidence of food allergy due to lipid transfer proteins: a comprehensive review. Clin Rev Allergy Immunol 2014;46:211-224.
Vereda A, van Hage M, Ahlstedt S, Ibañez MD, et al. Peanut allergy: clinical and immunologic differences among patients from 3 different geographic regions. J Allergy Clin Immunol 2011;127:603-607.
Ballmer-Weber BK, Skamstrup Hansen K, Sastre J, Andersson K, et al. Component-resolved in vitro diagnosis of carrot allergy in three different regions of Europe. Allergy 2012;67:758-766.
Fernández-Rivas M, Bolhaar S, González-Mancebo E, Asero R, et al. Apple allergy across Europe: how allergen sensitization profiles determine the clinical expression of allergies to plant foods. J Allergy Clin Immunol 2006;118:481-488.
Suratannon N, Ngamphaiboon J, Wongpiyabovorn J, Puripokai P, et al. Component-resolved diagnostics for the evaluation of peanut allergy in a low-prevalence area. Pediatr Allergy Immunol 2013;24:665-670.
Panzner P, Vachová M, Vítovcová P, Brodská P, et al. A comprehensive analysis of middle-European molecular sensitization profiles to pollen allergens. Int Arch Allergy Immunol 2014;164:74-82.
Kim J, Lee J, Park MR, Han Y, et al. Special consideration is required for the component-resolved diagnosis of egg allergy in infants. Ann Allergy Asthma Immunol 2014;112:53-77.
Masthoff LJN, Mattsson L, Zuidmeer-Jongejan L, Lidholm J, et al. Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults. J Allergy Clin Immunol 2013;132:393-399.
García Ortiz JC, Cosmes Martín P, Lopez-Asunolo A. Melon sensitivity shares allergens with Plantago and grass pollens. Allergy 1995;50:269-273.
Asero R, Monsalve R, Barber D. Profilin sensitization detected in the office by skin prick test: a study of prevalence and clinical relevance of profilin as a plant food
Bauer L, Ebner C, Hirschwehr R, Wüthrich B, et al. IgE crossreactivity between birch pollen, mugwort pollen and celery is due to at least three distinct cross-reacting allergens: immunoblot investigation of the birch-mugwort-celery syndrome. Clin Exp Allergy 1996;26:1161-1170.
Pauli G, Bessot JC, Dietemann-Molard A, Braun PA, et al. Celery sensitivity: clinical and immunological correlations with pollen allergy. Clin Allergy 1985;15:273-279.
Nieto A, Estornell F, Mazón A, Reig C, et al. Allergy to latex in spina bifida: a multivariate study of associated factors in 100 consecutive patients. J Allergy Clin Immunol 1996;98:501-507.
Mazón A, Nieto A, Estornell F, Reig C, et al. Factors that influence the presence of symptoms caused by latex allergy in children with spina bifida. J Allergy Clin Immunol 1997;99:600-604.
Pamies R, Oliver F, Raulf-Heimsoth M, Rihs H-P, et al. Patterns of latex allergen recognition in children sensitized to natural rubber latex. Pediatr Allergy Immunol 2006;17:55-59.
Garnier L, Selman L, Rouzaire P, Bouvier M, et al. Molecular allergens in the diagnosis of latex allergy. Eur Ann Allergy Clin Immunol 2012;44:73-79.
Nieto A, Mazon A, Pamies R, Díaz J. Espina bífida y alergia al látex. En: Blanco C, Quirce S, eds. Alergia al látex. 2ª ed. Barcelona: MRA Ediciones, 2002;149-174.
Blanco C, Navarro L, Figueroa J, Castillo R. El síndrome látexfrutas: relevancia clínica e identificación de alérgenos. En: Blanco C, Quirce S, eds. Alergia al látex. 2ª ed. Barcelona: MRA Ediciones, 2002;177-192.
Midoro-Horiuti T, Brooks EG, Goldblum RM. Pathogenesisrelated proteins of plants as allergens. Ann Allergy Asthma Immunol 2001;87:261-271.
Casquete-Román E, Rosado-Gil T, Postigo I, Guisantes JA, et al. Profilin cross-reactive panallergen causes latex sensitization in the pediatric population allergic to pollen. Ann Allergy Asthma Immunol 2012;109:215-219.
Manso L, Pastor C, Pérez-Gordo M, Cases B, et al. Crossreactivity between coconut and lentil related to a 7S globulin and an 11S globulin. Allergy 2010;65:1487-1488.
Sirvent S, Cantó B, Cuesta-Herranz J, Gómez F, et al. Act d 12 and Act d 13: two novel, masked, relevant allergens in kiwifruit seeds. J Allergy Clin Immunol 2014;133:1765-1767.
Sirvent S, Cantó B, Gómez F, Blanca N, et al. Detailed characterization of Act d 12 and Act d 13 from kiwi seeds: implication in IgE cross-reactivity with peanut and tree nuts. Allergy 2014;69:1481-1488.
Sirvent S, Akotenou M, Cuesta-Herranz J, Vereda A, et al. The 11S globulin Sin a 2 from yellow mustard seeds shows IgE cross-reactivity with homologous counterparts from tree nuts and peanut. Clin Transl Allergy 2012;2:23.
Gómez-Casado C, Murua-García A, Garrido-Arandia M, González-Melendi P, et al. Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins. FEBS Lett 2014;588:1501-1508.
Leung PS, Chow WK, Duffey S, Kwan HS, et al. IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen. J Allergy Clin Immunol 1996;98:954-961.
Pascual CY, Crespo JF, San Martin S, Ornia N, et al. Crossreactivity between IgE-binding proteins from Anisakis, German cockroach, and chironomids. Allergy 1997;52:514520.
Reese G, Ayuso R, Lehrer SB. Tropomyosin: an invertebrate pan-allergen. Int Arch Allergy Immunol 1999;119:247258.
Shanti KN, Martin BM, Nagpal S, Metcalfe DD, et al. Identification of tropomyosin as the major shrimp allergen and characterization of its IgE-binding epitopes. J Immunol 1993;151:5354-5363.
Bronnert M, Mancini J, Birnbaum J, Agabriel C, et al. Component-resolved diagnosis with commercially available D. pteronyssinus Der p 1, Der p 2 and Der p 10: relevant markers for house dust mite allergy. Clin Exp Allergy 2012;42:1406-1415.
Yadzir ZH, Misnan R, Murad S. Identification of tropomyosin as major allergen of white squid (Loligo edulis) by two-dimensional immunoblotting and mass spectrometry. Southeast Asian J Trop Med Public Health 2012;43:185-191.
Fernandes J, Reshef A, Patton L, Ayuso R, et al. Immunoglobulin E antibody reactivity to the major shrimp allergen, tropomyosin, in unexposed Orthodox Jews. Clin Exp Allergy 2003;33:956-961.
Gámez C, Zafra MP, Boquete M, Sanz V, et al. New shrimp IgE-binding proteins involved in mite-seafood crossreactivity. Mol Nutr Food Res 2014;58:1915-1925.
Boquete M, Iraola V, Morales M, Pinto H, et al. Seafood hypersensitivity in mite sensitized individuals: is tropomyosin the only responsible allergen? Ann Allergy Asthma Immunol 2011;106:223-229.
Mandallaz MM, de Weck AL, Dahinden CA. Bird-egg syndrome. Cross-reactivity between bird antigens and egg-yolk livetins in IgE-mediated hypersensitivity. Int Arch Allergy Appl Immunol 1988;87:143-150.
Quirce S, Marañón F, Umpiérrez A, de las Heras M, et al. Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome. Allergy 2001;56:754-762.
Szépfalusi Z, Ebner C, Pandjaitan R, Orlicek F, et al. Egg yolk alpha-livetin (chicken serum albumin) is a cross-reactive allergen in the bird-egg syndrome. J Allergy Clin Immunol 1994;93:932-942.
De Blay F, Hoyet C, Candolfi E, Thierry R, Pauli G. Identification of alpha livetin as a cross reacting allergen in a bird-egg syndrome. Allergy Proc 1994;15:77-78.
Bugajska-Schretter A, Elfman L, Fuchs T, Kapiotis S, et al. Parvalbumin, a cross-reactive fish allergen, contains IgEbinding epitopes sensitive to periodate treatment and Ca2+ depletion. J Allergy Clin Immunol 1998;101:67-74.
Sicherer SH. Clinical implications of cross-reactive food allergens. J Allergy Clin Immunol 2001;108:881-890.
Torres Borrego J, Martínez Cuevas JF, Tejero García J. Cross reactivity between fish and shellfish. Allergol Immunopathol 2003;31:146-151.
Hilger C, Grigioni F, Thill L, Mertens L, et al. Severe IgEmediated anaphylaxis following consumption of fried frog legs: definition of alpha-parvalbumin as the allergen in cause. Allergy 2002;57:1053-1058.
Kuehn A, Hilger C, Lehners-Weber C, Codreanu-Morel F, et al. Identification of enolases and aldolases as important fish allergens in cod, salmon and tuna: component resolved diagnosis using parvalbumin and the new allergens. Clin Exp Allergy 2013;43:811-822.
Kuehn A, Swoboda I, Arumugam K, Hilger C, et al. Fish allergens at a glance: variable allergenicity of parvalbumins, the major fish allergens. Front Immunol 2014;5:179.
García BE, Lizaso MT. Cross-reactivity syndromes in food allergy. J Investig Allergol Clin Immunol 2011;21:162-170.
Martelli A, De Chiara A, Corvo M, Restani P, et al. Beef allergy in children with cow’s milk allergy; cow’s milk allergy in children with beef allergy. Ann Allergy Asthma Immunol 2002;89:38-43.
Posthumus J, James HR, Lane CJ, Matos LA, et al. Initial description of pork-cat syndrome in the United States. J Allergy Clin Immunol 2013;131:923-925.
Cisteró-Bahíma A, Enrique E, San Miguel-Moncín MM, Alonso R, et al. Meat allergy and cross-reactivity with hamster epithelium. Allergy 2003;58:161-162.
Commins SP, James HR, Kelly EA, Pochan SL, et al. The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose. J Allergy Clin Immunol 2011;127:1286-1293.
Arkestål K, Sibanda E, Thors C, Troye-Blomberg M, et al. Impaired allergy diagnostics among parasite-infected patients caused by IgE antibodies to the carbohydrate epitope galactose-α 1,3-galactose. J Allergy Clin Immunol 2011;127:1024-1028.
Jacquenet S, Moneret-Vautrin DA, Bihain BE. Mammalian meat-induced anaphylaxis: clinical relevance of anti-galactose-alpha-1,3-galactose IgE confirmed by means of skin tests to cetuximab. J Allergy Clin Immunol 2009;124:603-605.
Chung CH, Mirakhur B, Chan E, Le Q-T, et al. Cetuximab-induced anaphylaxis and IgE specific for galactose-alpha-1,3galactose. N Engl J Med 2008;358:1109-1117.
Hilger C, Kler S, Arumugam K, Revets D, et al. Identification and isolation of a Fel d 1-like molecule as a major rabbit allergen. J Allergy Clin Immunol 2014;133:759-766.
Sastre J. Molecular diagnosis in allergy. Clin Exp Allergy 2010;40:1442-1460.
Asarnoj A, Glaumann S, Elfström L, Lilja G, et al. Anaphylaxis to peanut in a patient predominantly sensitized to Ara h 6. Int Arch Allergy Immunol 2012;159:209-212.
Bokanovic D, Aberer W, Hemmer W, Heinemann A, et al. Determination of sIgE to rPhl p 1 is sufficient to diagnose grass pollen allergy. Allergy 2013;68:1403-1409.
Ebo DG, Faber M, Sabato V, Leysen J, et al. Componentresolved diagnosis of wasp (yellow jacket) venom allergy. Clin Exp Allergy 2013;43:255-261.
Shin YS, Liu JN, Hur G-Y, Hwang E-K, et al. Clinical features and the diagnostic value of component allergen-specific IgE in Hymenoptera venom allergy. Allergy Asthma Immunol Res 2012;4:284-289.
Müller U, Schmid-Grendelmeier P, Hausmann O, Helbling A. IgE to recombinant allergens Api m 1, Ves v 1, and Ves v 5 distinguish double sensitization from crossreaction in venom allergy. Allergy 2012;67:1069-1073.
Heaps A, Carter S, Selwood C, Moody M, et al. The utility of the ISAC allergen array in the investigation of idiopathic anaphylaxis. Clin Exp Immunol 2014;177:483-490.
Fötisch K, Altmann F, Haustein D, Vieths S. Involvement of carbohydrate epitopes in the IgE response of celery-allergic patients. Int Arch Allergy Immunol 1999;120:30-42.
Ebo DG, Hagendorens MM, Bridts CH, De Clerck LS, et al. Sensitization to cross-reactive carbohydrate determinants and the ubiquitous protein profilin: mimickers of allergy. Clin Exp Allergy 2004;34:137-144.
Mari A. IgE to cross-reactive carbohydrate determinants: analysis of the distribution and appraisal of the in vivo and in vitro reactivity. Int Arch Allergy Immunol 2002;129:286-295.
Van der Veen MJ, van Ree R, Aalberse RC, Akkerdaas J, et al. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J Allergy Clin Immunol 1997;100:327-334.
Wahn U, Matricardi P. The allergic march: relevance of molecular diagnosis in allergy. What can we predict? Where could we internene? 4th ed. Hamburg: Allergopharma Editor, 2012;12-17.
Asarnoj A, Nilsson C, Lidholm J, Glaumann S, et al. Peanut component Ara h 8 sensitization and tolerance to peanut. J Allergy Clin Immunol 2012;130:468-472.
Bernhisel-Broadbent J, Dintzis HM, Dintzis RZ, Sampson HA. Allergenicity and antigenicity of chicken egg ovomucoid (Gal d III) compared with ovalbumin (Gal d I) in children with egg allergy and in mice. J Allergy Clin Immunol 1994;93:1047-1059.
Caubet JC, Kondo Y, Urisu A, Nowak-Węgrzyn A. Molecular diagnosis of egg allergy. Curr Opin Allergy Clin Immunol 2011;11:210-215.
Leonard SA, Sampson HA, Sicherer SH, Noone S, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol 2012;130:473-480.
Kohno K, Matsuo H, Takahashi H, Niihara H, et al. Serum gliadin monitoring extracts patients with false negative results in challenge tests for the diagnosis of wheatdependent exercise-induced anaphylaxis. Allergol Int 2013;62:229-238.
Park HJ, Kim JH, Kim JE, Jin HJ, et al. Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis. Int Arch Allergy Immunol 2012;157:147-150.
Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek T, et al. Allergen chip diagnosis for soy-allergic patients: Gly m 4 as a marker for severe food-allergic reactions to soy. Int Arch Allergy Immunol 2013;161:229-233.
Ebo DG, Verweij MM, Sabato V, Hagendorens MM, et al. Hazelnut allergy: a multi-faced condition with demographic and geographic characteristics. Acta Clin Belg 2012;67:317-321.
Pascal M, Muñoz-Cano R, Reina Z, Palacín A, et al. Lipid transfer protein syndrome: clinical pattern, cofactor effect and profile of molecular sensitization to plant-foods and pollens. Clin Exp Allergy 2012;42:1529-1539.
Novembre E, Mori F, Contestabile S, Rossi ME, et al. Correlation of anti-Pru p 3 IgE levels with severity of peach allergy reactions in children. Ann Allergy Asthma Immunol 2012;108:271-274.
Vieira T, Cunha L, Neves E, Falcão H. Diagnostic usefulness of component-resolved diagnosis by skin prick tests and specific IgE to single allergen components in children with allergy to fruits and vegetables. Allergol Immunopathol 2014;42:127-135.
Caubet JC, Nowak-Węgrzyn A, Moshier E, Godbold J, et al. Utility of casein-specific IgE levels in predicting reactivity to baked milk. J Allergy Clin Immunol 2013;131:222-224.
Ahrens B, Lopes de Oliveira LC, Grabenhenrich L, Schulz G, et al. Individual cow’s milk allergens as prognostic markers for tolerance development? Clin Exp Allergy 2012;42:1630-1637.
Eller E, Bindslev-Jensen C. Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy 2013;68:190-194.
Lopes de Oliveira LC, Aderhold M, Brill M, Schulz G, et al. The value of specific IgE to peanut and its component Ara h 2 in the diagnosis of peanut allergy. J allergy Clin Immunol Pract 2013;1:394-398.
Lee MF, Song PP, Hwang GY, Lin SJ, et al. Sensitization to Per a 2 of the American cockroach correlates with more clinical severity among airway allergic patients in Taiwan. Ann Allergy Asthma Immunol 2012;108:243-248.
Kato Y, Oozawa E, Matsuda T. Decrease in antigenic and allergenic potentials of ovomucoid by heating in the presence of wheat flour: dependence on wheat variety and intermolecular disulfide bridges. J Agric Food Chem 2001;49:3661-3665.
Ando H, Movérare R, Kondo Y, Tsuge I, et al. Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy. J Allergy Clin Immunol 2008;122:583-588.
Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, et al. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol 2008;122:977-983.
Turner PJ, Mehr S, Sayers R, Wong M, et al. Loss of allergenic proteins during boiling explains tolerance to boiled peanut in peanut allergy. J Allergy Clin Immunol 2014;134:751-753.
Beyer K, Morrow E, Li XM, Bardina L, et al. Effects of cooking methods on peanut allergenicity. J Allergy Clin Immunol 2001;107:1077-1081.
Boyano-Martínez T, Pedrosa M, Belver T, Quirce S, et al. Peach allergy in spanish children: tolerance to the pulp and molecular sensitization profile. Pediatr Allergy Immunol 2013;24:168-172.
Antonicelli L, Massaccesi C, Braschi MC, Cinti B, et al. Component resolved diagnosis in real life: the risk assessment of food allergy using microarray-based immunoassay. Eur Ann Allergy Clin Immunol 2014;46:30-34.
Sastre J, Landivar ME, Ruiz-García M, Andregnette-Rosigno MV, et al. How molecular diagnosis can change allergenspecific immunotherapy prescription in a complex pollen area. Allergy 2012;67:709-711.
Treudler R, Simon JC. Overview of component resolved diagnostics. Curr Allergy Asthma Rep 2013;13:110-117.
Moreno C, Justicia JL, Quiralte J, Moreno-Ancillo A, et al. Olive, grass or both? Molecular diagnosis for the allergenimmunotherapy selection in polysensitized pollinic patients. Allergy 2014;69:1357-1363.
Stringari G, Tripodi S, Caffarelli C, Dondi A, et al. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever. J Allergy Clin Immunol 2014;134:75-81.
Rossi RE, Melioli G, Monasterolo G, Harwanegg C, et al. Sensitization profiles in polysensitized patients from a restricted geographical area: further lessons from multiplexed component resolved diagnosis. Eur Ann Allergy Clin Immunol 2011;43:171-175.
Passalacqua G. The use of single versus multiple antigens in specific allergen immunotherapy for allergic rhinitis: review of the evidence. Curr Opin Allergy Clin Immunol 2014;14:20-24.
Lafuente I, Pina R, Uixera S, Calderon R, et al. Component resolved diagnosis: performance of specific IgE to Alternaria compared to Alt a 1. Clin Transl Allergy 2014;4:15.
Asero R. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. Clin Exp Allergy 1998;28:1368-1373.
Asero R. Effects of birch pollen SIT on apple allergy: a matter of dosage? Allergy 2004;59:1269-1271.
Pereira C, Bartolomé B, Asturias JA, Ibarrola I, et al. Specific sublingual immunotherapy with peach LTP (Pru p 3). One year treatment: a case report. Cases J 2009;12:6553.
Fernández-Rivas M, Garrido Fernández S, Nadal JA, Díaz de Durana MD, et al. Randomized double-blind, placebocontrolled trial of sublingual immunotherapy with a Pru p 3 quantified peach extract. Allergy 2009;64:876-883.
García BE, González-Mancebo E, Barber D, Martín S, et al. Sublingual immunotherapy in peach allergy: monitoring molecular sensitizations and reactivity to apple fruit and Platanus pollen. J Investig Allergol Clin Immunol 2010;20:514-520.
Van Ree R, Antonicelli L, Akkerdaas JH, Garritani MS, et al. Possible induction of food allergy during mite immunotherapy. Allergy 1996;51:108-113.
Gámez C, Sánchez-García S, Ibáñez MD, López R, et al. Tropomyosin IgE-positive results are a good predictor of shrimp allergy. Allergy 2011;66:1375-1383.
Douladiris N, Sawatianos S, Roumpedaki I, Skevaki C, et al. A molecular diagnostic algorithm to guide pollen immunotherapy in southern Europe: towards componentresolved management of allergic diseases. Int Arch Allergy Immunol 2013;162:163-172.
Melioli G, Spenser C, Reggiardo G, Passalacqua G, et al. Allergenius, an expert system for the interpretation of allergen microarray results. World Allergy Organ J 2014;7:15.
Sicherer SH, Wood RA. Advances in diagnosing peanutNallergy. J allergy Clin Immunol Pract 2013;1:1-13.
Bernardi ML, Picone D, Tuppo L, Giangrieco I, et al. Physicochemical features of the environment affect the protein conformation and the immunoglobulin E reactivity of kiwellin (Act d 5). Clin Exp Allergy 2010;40:1819-1826.
Lin J, Bardina L, Shreffler WG, Andreae DA, et al. Development of a novel peptide microarray for large-scale epitope mapping of food allergens. J Allergy Clin Immunol 2009;124:315-322.
Wang J, Lin J, Bardina L, Goldis M, et al. Correlation of IgE/ IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol 2010;125:695-702.
Perez-Gordo M, Pastor-Vargas C, Lin J, Bardina L, et al. Epitope mapping of the major allergen from Atlantic cod in Spanish population reveals different IgE-binding patterns. Mol Nutr Food Res 2013;57:1283-1290.
Pacios LF, Pacios L, Tordesillas L, Cuesta-Herranz J, et al. Mimotope mapping as a complementary strategy to define allergen IgE-epitopes: peach Pru p 3 allergen as a model. Mol Immunol 2008;45:2269-2276.
Järvinen KM, Beyer K, Vila L, Chatchatee P, et al. B-cell epitopes as a screening instrument for persistent cow’s milk allergy. J Allergy Clin Immunol 2002;110:293-297.
Yokooji T, Kurihara S, Murakami T, Chinuki Y, et al. Characterization of causative allergens for wheat-dependent exercise-induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap. Allergol Int 2013;62:435-445.
Migueres M, Dávila I, Frati F, Azpeitia A, et al. Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease. Clin Transl Allergy 2014;4:16.
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