Keywords
Allergic rhinitis
Allergen
Sensitization
How to Cite
Plaudit
Abstract
Objective: The objective of this research was to measure the correlation of the expression of IL-4 with allergen sensitization in patients with allergic rhinitis.
Methods: Descriptive analytics was used as a method in this research, with a cross-sectional approach. The subjects were 37 persons with allergic rhinitis who met the inclusion and exclusion criteria. This research was conducted in patients with clinical manifestations of symptoms of allergic rhinitis, and skin prick tests were carried out with ten types of allergens, which are: house dust, cotton, chicken feathers, shrimp, tuna, chicken egg-yolk, chicken egg-white, peanuts, tea, and chocolate. Venous blood sampling was performed for the Interleukin-4 (IL-4) test by using an ELISA device.
Results: The respondents were 37 patients with allergic rhinitis, of which 26 (70.3 %) were women and 11 (29.7 %) were men. The highest sensitivity to inhaled allergens in patients with rhinitis was to house dust in 31 samples (83.8 %).
The correlation of the expression of IL-4 with sensitization to allergens in patients with allergic rhinitis based on the Spearman test resulted in p > 0.05, not significant with some allergens in a negative correlation.
Conclusion: There was no significant correlation between the expression of IL-4 and the sensitization to allergens in patients with allergic rhinitis.
References
Nolte H, Nepper-Christensen S, Backer V. Unawareness and undertreatment of asthma and allergic rhinitis in a general population. Respir Med. 2006;100(2):354-362. DOI 10.1016/j.rmed.2005.05.012
Katelaris CH, Lee BW, Potter PC, Maspero JF, Cingi C, Lopatin A, et al. Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy. 2012;42(2):186-207. DOI: 10.1111/j.1365-2222.2011.03891.x
Migueres M, Dávila I, Frati F, Azpeitia A, Jeanpetit Y, Lhéritier-Barrand M, et al. Types of sensitization to aeroallergens: definitions, prevalences and impact on the diagnosis and treatment of allergic respiratory disease. Clin Transl Allergy. 2014;4:16. DOI: 10.1186/2045-7022-4-16
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 Update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63(Suppl 86):S8–S160. DOI:10.1111/j.1398-99995.2007.01620.x
Brożek JL, Bousquet J, Baena CE, Bonini S, Canonica GW, Casale TB, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol. 2010;126(3):466-476. DOI: 10.1016/j.jaci.2010.06.047
Kırmaz C, Bayrak P, Yıl-maz O, Yüksel H. Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur Cytokine Netw. 2005;16(2):128-134.
Albrecht M, Dittrich AM. Cytokines in sensitization to aeroallergens. Allergol Select. 2018;2(1):94-100. DOI: 10.5414/ALX1480E
Dittrich AM, Chen HC, Xu L, Ranney P, Connolly S, Yarovinsky TO, et al. A new mechanism for inhalational priming: IL-4 bypasses innate immune signals. J Immunol. 2008;181:7307-7315. DOI: 10.4049/jimmunol.181.10.7307
Li L, Li Y, Zeng X, Li J, Du XY. Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children. Genet Mol Res. 2016;15(4):534-543. DOI: 10.4238/gmr15048873
Borish LC, Nelson HS, Corren J, Bensch G, Busse WW, Whitmore JB, et al. Efficacy of soluble IL-4 receptor for the treatment of adults with asthma. J Allergy Clin Immunol. 2001;107(6):963-970. DOI: 10.1067/mai.2001.115624
Wenzel S, Wilbraham D, Fuller R, Getz-Burmesiter E, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet. 2007;370(9596):1422-1431. DOI: 10.1016/S0140-6736(07)61600-6
Daniel WW. Biostatistics: a foundation for analysis in the health sciences. EEUU: John Wiley & Sons; 1999.
Valatabar N, Hosseinpourfeizi M, Safaralizadeh R, Shabestari MS. Relationships between IL-13 and IL-4 genotypes and aeroallergens with risk of allergic rhinitis in Iranian-Azeri. Pediatr Allergy Immunol Pulmonol. 2020;33(1):33-38. DOI: 10.1089/ped.2019.1099
Tyurin YA, Lissovskaya SA, Fassahov RS, Mustafin IG, Shamsutdinov AF, Shilova MA, et al. Cytokine profile of patients with allergic rhinitis caused by pollen, mite, and microbial allergen sensitization. J Immunol Res. 2017;2017:1-8. DOI: 10.11155/2017/3054217
Lu M-P, Chen R-X, Wang M-L, Zhu X-J, Zhu L-P, Yin M, et al. Association study on IL4, IL13 and IL4RA polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population. PLoS One. 2011;6(11):e27363. DOI: 10.1371/journal.pone.0027363
Al-Rawashdeh BM, Sadaalhanjori A, Ali E, Zihlif M. Association of IL-4 polymorphisms with allergic rhinitis in Jordania population. Medicina (Kaunas). 2020;56(4):179. DOI: 10.3390/medicina56040179
Narozna B, Hoffmann A, Sobkowiak P, Schoneich N, Bręborowicz A, Szczepankiewicz A, et al. Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: a case control study. Adv Med Sci. 2016;61(1):40-45. DOI: 10.1016/j.advms.2015.07.003
Korzycka-Zaborowska B, Zielińska-Bliźniewska H, Zaborowski A, Oiszewski J. Association of-590 C/T Il-4 gene promoter polymorphism with atopy in Polish patients with allergic rhinitis. J Allergy Disord Ther. 2015;2:100004. DOI: 10.24966/ADT-749X/100004
Yuen APW, Cheung S, Tang KC, Ho WK, Wong BYH, Cheaung ACS, Ho ACW. The skin prick test results of 977 patients suffering from chronic rhinitis in Hong Kong. Hong Kong Med J. 2007;13(2):131-136. Disponible en: https://www.hkmj.org/system/files/hkm0704p131.pdf
Navarro-Locsin CG, Lim-Jurado M. Aeroallergen sensitization and associated comorbid diseases of an adult Filipino population with allergic rhinitis. Asia Pac Allergy. 2018;8(3):e25. DOI: 10.5415/apallergy.2018.8.e25
Oncham S, Udomsubpayakul U, Laisuan W. Skin prick test reactivity to aeroallergens in adult allergy clinic in Thailand: a 12-year retrospective study. Asia Pac Allergy. 2018;8(2):e17. DOI: 10.5415/apallergy.2018.8.e17
Pawankar R, Canonica G, Holgate S, Lockey R, Blaiss, M. WAO White Book on Allergy; Allergy Organization: Milwaukee, WI, USA, 2011; Volume 3: 156–157.
Passali D, Cingi C, Staffa P, Passali F, Muluk NB, Bellussi, ML. The international study of the allergic rhinitis survey: outcomes from 4 geographical regions. Asia Pac J Allergy. 2018;8(1):e7. DOI: 10.5415/apallergy.2018.8.e7
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