Sensibilización y alergia a látex en residentes quirúrgicos del Hospital General de México

Mariana Esther Arroyo-Cruz, Rodrigo Collado-Chagoya, Javier Hernández-Romero, Alejandro Eliosa Alvarado-Gumaro, Ana del Carmen García-González, Rosa Isela Campos-Gutiérrez, Andrea Aída Velasco-Medina, Guillermo Velázquez-Sámano

Resumen


Antecedentes: La prevalencia de alergia al látex oscila entre 0.8 y 6.5 % y es la segunda causa de anafilaxia perioperatoria. Los principales factores de riesgo son ser trabajador de la salud o productor de látex, horas de utilización de guantes o productos de látex, exposición a otros irritantes de manos, antecedente de atopia, defectos del cierre del tubo neural o numerosas cirugías a edad temprana.

Objetivo: Determinar la frecuencia de sensibilización al látex en médicos residentes del área quirúrgica del Hospital General de México.

Métodos: Estudio clínico prospectivo, transversal, descriptivo, mediante la realización de prueba de punción cutánea a residentes del área quirúrgica del Hospital General de México, Secretaría de Salud, Ciudad de México.

Resultados: Se incluyeron 92 sujetos a los cuales se les realizó pruebas cutáneas, participando 11 especialidades quirúrgicas. La sensibilización al látex en esta población fue de 11.9 % y la presencia de alergia al látex de 10.8 %.

Conclusiones: Se demuestró alta frecuencia de sensibilización y alergia al látex en los residentes quirúrgicos del Hospital General de México, lo que indica la necesidad de desarrollar políticas y procedimientos para los trabajadores de salud con alergia al látex y la capacitación continua de empleados sobre alergia al látex.


Palabras clave


Alergia al látex; Residentes quirúrgicos; Sensibilización al látex

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Referencias


Nel A, Gujuluva C. Latex antigens: Identification and use in clinical and experimental studies, including cross-reactivity with food and pollen allergens. Ann Allergy Asthma Immunol. 1998;81(5):388-396. DOI: 10.1016/S1081-1206(10)63135-3

Rolland JM, O’Hehir RE. Latex allergy: A model for therapy. Clin Exp Allergy. 2008;38(6):898-912. DOI: 10.1111/j.1365-2222.2008.02984.x

Poley GE, Slater JE. Latex allergy. J Allergy Clin Immunol. 2000;105:1054-1062.

Kevin KJ, Sussman G. Latex allergy: Where are we now and how did we get there? J Allergy Clin Immunol Pract. 2017;5(5):1212-1216. DOI: 10.1016/j.jaip.2017.05.029

Fuchs T, Spitzauer S, Veente C, Hevler J, Kapiotis S, Rumpold H, et al. Natural latex, grass pollen and weed pollen share IgE epitopes. J Allergy Clin Immunol. 1997;100(3):356-364.

Schuler S, Ferrari G, Schmid-Grendelmeier P, Harr T. Microarray-based component-resolved diagnosis of latex allergy: Isolated IgE-mediated sensitization to latexprofilin Hev b8 may act as confounder. Clin Transl Allergy. 2013;3(1):11. DOI: 10.1186/2045-7022-3-11

Amarasekera M, Rathnamalala N, Samaraweera S, Jinadasa M. Prevalence of latex allergy among healthcare workers. Int J Occup Med Environ Health. 2010;23(4):391-396. DOI: 10.2478/v10001-010-0040-5

Bueno-De-Sä A, Camilo-Araujo RF, Cavalheiro S, Carvalho-Mallozi M, Solé D. Profile of latex sensitization and allergies in children and adolescents with myelomeningocele in Sao Paulo, Brazil. J Investig Allergol Clin Immunol. 2013;23(1):43-49.

Parisi CAS, Petriz NA, Busaniche JN, Cortines MC, Frangi FA, Portillo SA, et al. Prevalence of latex allergy in a population of patients diagnosed with myelomeningocele. Arch Argent Pediatr. 2016;114(1):30-35. DOI: 10.5546/aap.2016.eng.30

Phaswana SM, Naidoo S. The prevalence of latex sensitization and allergy and associated risk factors among healthcare workers using hypoallergenic latex gloves at King Edward VIII Hospital, KwaZulu-Natal South Africa: A crosssectional study. BMJ Open. 2013;3(12):e002900. DOI: 10.1136/bmjopen-2013-002900

El-Sayed ZA, El-Sayed SS, Zaki RM, Salama MA. Latex hypersensitivity among allergy Egyptian children: relation to parental/self reports. Pulm Med. 2014;2014:629187. DOI: 10.1155/2014/629187

Macías-Robles AP, Morán-Mendoza AR. Prevalencia de sensibilización al látex mediante prueba cutánea (prick test) en pacientes con malformaciones genitourinarias con más de tres intervenciones quirúrgicas. Rev Alerg Mex. 2016;63(2):154-162.

Draisci G, Zanfini BA, Nucera E, Catarci S, Sangregorio R, Schiavino D, et al. Latex sensitization: a special risk for the obstetric population? Anesthesiology. 2011;114(3):565-569. DOI: 10.1097/ALN.0b013e318206ff50

Suli A, Parziale M, et al. Prevalence and risk factors for latex allergy: A cross sectional study on health-care workers of an Italian hospital. J Invest Allergol Clin Immunol. 2004;14(1):64-69. Disponible en: https://pdfs.semanticscholar.org/4c58/fda23791da357d6883f415e031836a496154.pdf

Lieberman P. Anaphylactic reactions during surgical and medical procedures. J Allergy Clin Immunol. 2002;110(Suppl 2):S64-S69.

Kannan JA, Bernstein JA. Perioperative anaphylaxis: Diagnosis, evaluation, and management. Immunol Allergy Clin North Am. 2015;35(2):321-334. DOI: 10.1016/j.iac.2015.01.002

Cabañes N, Igea JM, De-La-Hoz B, Agustín P, Blanco C, Domínguez J, et al. Latex allergy: Position Paper. J Investing Allergol Clin Immunol. 2012;22(5):313-330.

Rihs HP, Chen Z, Ruëff F, Cremer R, Raulf-Heimsoth M, Baur X, et al. HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy. J Allergy Clin Immunol. 2002;110(3):507-514. DOI: 10.1067/mai.2002.127282

Brown RH, Hamilton RG, Mintz M, Jedlicka AE, Scott AL, Kleeberger SR. Genetic predisposition to latex allergy: role of interleukin 13 and interleukin 18. Anesthesiology 2005;102(3):496-502.

Caballero ML, Quirce S. Identification and practical management of latex allergy in occupational settings. Expert Rev Clin Immunol. 2015;11(9):977-992. DOI: 10.1586/1744666X.2015.1059754

Supapvanich C, Povey AC, de Vocht F. Respiratory and dermal symptoms in Thai nurses using latex products. Occup Med (Lond). 2013;63(6):425-428.

UpToDate [sitio web]. Hamilton GR. Latex allergy: Epidemiology, clinical manifestations, and diagnosis. [Consultado 2017 Sep %].

Ebo DG, Hagendorens MM, De-Knop KJ, Verweij MM, Bridts CH, De Clerck LS, et al. Component resolved diagnosis from latex allergy by microarray. Clin Exp Allergy. 2010;40(2):348-358. DOI: 10.1111/j.1365-2222.2009.03370.x

Gabriel MF, Tavares-Ratado P, Peixinho CM, Romeira AM, Taborda-Barata L, Postigo I, et al. Evaluation and comparison of commercially available latex extracts for skin prick tests. J Investig Allergol Clin Immunol. 2013;23(7):478-486.

Caimmi D. Raschetti R, Pons P, et al. Cross-reactivity between cypress pollen and latex assessed using skin test. J Investig Allergol Clin Immunol. 2012;22(7):525-526.

Crepy MN. Rubber: New allergens and preventive measures. Eur J Dermatol. 2016;26(6):523-530. DOI: 10.1684/ejd.2016.2839

Yeang HY, Cheong KF, Sunderasan E, Hamzah S, Chew NP, Hamid S, et al. The 14.6 kD rubber elongation factor (Hev b 1) and 24 kd (Hev b 3) rubber particle proteins are recognized by IgE from patients with spina bifida and latex allergy. J Allergy Clin Immunol. 1996;98(3):628-639.

Binkley M, Schroyer T, Catalfano J. Latex allergies: A review of recognition, evaluation, management, prevention, education, and alternative product use. J Athl Train. 2003;38(2):133-140.

Nettis E, Delle-Done P, Di-Leo E, Fantini P, Passalacqua G, Bernardini R, et al. Latex immunotherapy: state of art. Ann Allergy Asthma Immunol. 2012;109(3):160-165. DOI: 10.1016/j.anai.2012.07.004

Sridharan K, Sivaramakrishnan G, Sublingual immunotherapy in patients with latex allergy: Systematic review and meta-analysis of randomized controlled trials. J Dermatolog Treat. 2017;28(7):600-605. DOI: 10.1080/09546634.2017.1303567

Leynadier F, Doudou O, Gaouar H, Le Gros V, Bourdeix I, Guyomarch-Cocco L,et al. Effect of omalizumab in health care workers with occupational latex allergy. J Allergy Clin Immunol. 2004;113(2):360-361. DOI: 10.1016/j.jaci.2003.11.020

Galindo MJ, Quirce S, Garcia OL. Latex allergy in primary care providers. J Investig Allergol Clin Immunol. 2011;21(6):459-465. Disponible en: https://pdfs.semanticscholar.org/a342/33f979938b5d2849d34d14212dc8e33dfc63.pdf

Baur X, Chen Z, Allmers H. Can a threshold limit value for natural rubber latex airborne allergens be defined? J Allergy Clin Immunol. 1998;101(1 Pt 1):24-27. DOI: 10.1016/S0091-6749(98)70188-5

Charous BL, Schuenemann PJ, Swanson MC. Passive dispersion of latex aeroallergen in a healthcare facility. Ann Allergy Asthma Immunol. 2000;85(4):285-290. DOI: 10.1016/S1081-1206(10)62531-8

Allmers H, Schmengler J, John SM. Decreasing incidence of occupational contact urticaria caused by natural rubber latex allergy in German health care workers. J Allergy Clin Immunol. 2004;114(2):347-351. DOI: 10.1016/j.jaci.2004.05.054

Phillips VL, Goodrich MA, Sullivan TJ. Health care worker disability due to latex allergy and asthma: A cost analysis. Am J Public Health. 1999;89(7):1024-1028.

Turjanmaa K, Kanto M, Kautiainen H, Reunala T, Palosuo T. Long-term outcome of 160 adult patients with natural rubber latex allergy. J Allergy Clin Immunol. 2002;110(Suppl 2):S70-S74.

Damas-Fuentes RM, Pérez-León M, Piñero-González M, Sangil-Monroy N, Molero-Gómez R, Domínguez-Lantigua P. Drugs having latex and therapeutic alternatives in hospital formulary. Farm Hosp. 2015;39: 44-58. DOI: 10.7399/fh.2015.39.1.7642




DOI: http://dx.doi.org/10.29262/ram.v65i2.331

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