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Abstract
Background: Adverse drug events (ADEs) comprise the largest category of adverse events in hospitalized patients. ADEs encompasses adverse drug reaction (ADR) and medication error (ME).Objective: To determine prevalence and risk factors of ADEs in patients hospitalized in a General Hospital.
Methods: Case-control, observational, retrospective study of patients with ADEs. Statistical analysis: percentages, frequencies, averages. Odds ratio, Chi square. Multiple binary logistic regression. Statistical Package, for the Social Sciences 23.
Results: ADEs prevalence 3.6%. 132 patients, 66 cases (26 ME and 40 ADR), 66 controls, reported medications: antibiotics, anti-inflammatories, mean age 35 years (ES17.4), ADEs, sex: 39.3% men, 60.7% women, reported services; emergencies, surgery, frequent route of administration: intravenous (32.3%) frequent symptoms: cutaneous. ADR associated symptoms: TypeA pruritus OR 8.5 p=0.001(95%CI 0.035-0.393), TypeB pruritus OR 11 p=0.001(95%CI 0.021-0.368) urticaria OR19 p=0.005(95%CI 0.007-0.412). Associated risk factors ADEs : woman OR2.6p=0.05(CI95%1.33-5.43), history of allergy OR 3.4p=0.033(CI95%1.04-8.40), prolonged hospital stay OR5.4p=0.023 (CI95%3.82-6.74). Conclusions: The largest Part of the ADEs were ME or type A ADR, both of which are preventable reactions, so patient safety must be a priority when prescribing.
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