Senear-Usher syndrome: An exceptional case

Abstract

Background: Among the autoimmune diseases causing erosive lesions and blisters on skin and mucous membranes is pemphigus. Within this is a rare subtype known as seborrheic pemphigus or Senar-usher syndrome which is characterized by broken blisters and crusts involving the seborrheic areas. Its pathogenesis is related to an autoimmune mechanism leading to lysis of desmosomes; IgG antibodies against desmoglein 1 and 3, however, this may be a misguided theory.

Case report: A 40-year-old female patient recently diagnosed with HIV with no known time of evolution; she presented a condition of 45 days evolution consisting of pruritic and painful thick crusty lesions with erythematous base, in the entire facial region with subsequent extension to the chest, upper limbs and abdomen and finally to the genitals and lower limbs. She received oral prednisolone therapy with adequate improvement of the lesions.

Conclusion: It is a rare disease that can originate from states of immunosuppression secondary to pathologies such as HIV, so the current pathogenesis of pemphigus should be reconsidered.