Resumen
El desarrollo de los linfocitos B a partir de células troncales hematopoyéticas es un proceso altamente regulado y continuo en el que se pierden gradualmente los potenciales de diferenciación múltiple y se adquieren funciones especializadas del linaje. A 50 años de su descubrimiento, el conocimiento actual de la diferenciación temprana de las células B proviene, en gran medida, del aislamiento y caracterización de los progenitores en la médula ósea que dan inicio al programa linfoide y de la definición de patrones de actividad transcripcional que controlan las decisiones de los destinos celulares. De especial relevancia ha sido la intercomunicación de los precursores con los componentes del microambiente hematopoyético para la generación de nuevos modelos que integren todos los elementos de regulación de este complejo proceso y para la comprensión de esta rama del sistema inmunológico adaptativo en la enfermedad. Esta revisión ofrece un panorama general del complejo proceso de diferenciación linfoide: la organización jerárquica y características biológicas de las células primitivas que participan en sus etapas más tempranas, hasta los principios que rigen su interdependencia con el microambiente hematopoyético.Referencias
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