Resumen
En los últimos años se ha descrito un nuevo fenotipo de rinitis, caracterizado por la producción local de IgE específica, sin evidencia de atopia sistémica, el cual se ha denominado rinitis alérgica local. Entender los mecanismos fisiopatológicos implicados y el comportamiento de este fenotipo se traducen en el desarrollo de estrategias y tratamientos que mejoran la calidad de vida de los pacientes con esta enfermedad. En este documento se presenta una revisión actualizada de la información disponible relativa a esta enfermedad y de los aspectos pendientes por resolver.
Referencias
Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, Togias A, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA2LEN and AllerGen). Allergy. 2008;63(Suppl 86):8-160. DOI: 10.1111/j.1398-9995.2007.01620.x
Brozek JL, Bousquet J, Agache I, Agarwal A, Bachert C, Bosnic-Anticevich S, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140(4):950-958. DOI: 10.1016/j.jaci.2017.03.050
Eifan AO, Durham SR. Pathogenesis of rhinitis. Clin Exp Allergy. 2016;46(9):1139-1151. DOI: 10.1111/cea.12780
Aït-Khaled N, Pearce N, Anderson HR, Ellwood P, Montefort S, Shah J, et al. Global map of the prevalence of symptoms of rhinoconjunctivitis in children: The International Study of Asthma and Allergies in Childhood (ISAAC) phase three. Allergy. 2009;64(1):123-148. DOI: 10.1111/j.1398-9995.2008.01884.x
Kakli HA, Riley TD. Allergic rhinitis. Prim Care. 2016;43(3):465-475. DOI: 10.1016/j.pop.2016.04.009
Dennis R, Caraballo L, García E, Caballero A, Aristizabal G, Córdoba H, et al. Asthma and other allergic conditions in Colombia: A study in 6 cities. Ann Allergy Asthma Immunol. 2004;93(6):568-574. DOI: 10.1016/S1081-1206(10)61265-3
Dennis RJ, Caraballo L, García E, Rojas MX, Rondón MA, Pérez A, et al. Prevalence of asthma and other allergic conditions in Colombia 2009-2010: A cross-sectional study. BMC Pulm Med. 2012;12(1):17. Disponible en: https://bmcpulmmed.biomedcentral.com/articles/10.1186/1471-2466-12-17
Johansson SGO, Bieber T, Dahl R, Friedmann PS, Lanier BQ, Lockey RF, et al. Revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of the World Allergy Organization, October 2003. J Allergy Clin Immunol. 2004;113(5):832-836. DOI: 10.1016/j.jaci.2003.12.591
Papadopoulos NG, Bernstein JA, Demoly P, Dykewicz M, Fokkens W, Hellings PW, et al. Phenotypes and endotypes of rhinitis and their impact on management: A PRACTALL report. Allergy. 2015;70(5):474-494. DOI: 10.1111/all.12573
Settipane RA, Charnock DR. Epidemiology of rhinitis: allergic and nonallergic. Clin Allergy Immunol. 2007;19:23-34.
Rondón C, Fernández J, López S, Campo P, Doña I, Torres MJ, et al. Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis. J Allergy Clin Immunol. 2009;124(5):1005-1011. DOI: 10.1016/j.jaci.2009.07.018
Rondón C, Canto G, López M. Local allergic rhinitis: A new entity, characterization and further studies. Curr Opin Allergy Clin Immunol. 2010;10(1):1-7. DOI: 10.1097/ACI.0b013e328334f5fb
Rondón C, Campo P, Herrera R, Blanca-López N, Meléndez L, Canto G, et al. Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis. J Allergy Clin Immunol. 2011;128(6):1192-1197. DOI: 10.1016/j.jaci.2011.06.012
Rondón C, Eguiluz-Gracia I, Campo P. Is the evidence of local allergic rhinitis growing? Curr Opin Allergy Clin Immunol. 2018;18(4):342-349. DOI: 10.1097/ACI.0000000000000456
Campo P, Eguiluz-Gracia I, Bogas G, Salas M, Plaza Serón C, Pérez N, et al. Local allergic rhinitis: implications for management. Clin Exp Allergy. 2019;49(1):6-16. DOI: 10.1111/cea.13192
Carney AS, Powe DG, Huskisson RS, Jones NS. Atypical nasal challenges in patients with idiopathic rhinitis: More evidence for the existence of allergy in the absence of atopy? Clin Exp Allergy. 2002;32(10):1436-1440. DOI: 10.1046/j.1365-2745.2002.01465.x
Campo P, Salas M, Blanca-López N, Rondón C. Local allergic rhinitis. Immunol Allergy Clin North Am. 2016;36(2):321-332. DOI: 10.1016/j.iac.2015.12.008
Shin YS, Jung C-G, Park H-S. Prevalence and clinical characteristics of local allergic rhinitis to house dust mites. Curr Opin Allergy Clin Immunol. 2018;18(1):10-15. DOI: 10.1097/ACI.0000000000000413
Cheng KJ, Xu YY, Liu HY, Wang SQ. Serum eosinophil cationic protein level in Chinese subjects with nonallergic and local allergic rhinitis and its relation to the severity of disease. Am J Rhinol Allergy. 2013;27(1):8-12. DOI: 10.2500/ajra.2013.27.3845
Jang TY, Kim YH. Nasal provocation test is useful for discriminating allergic, nonallergic, and local allergic rhinitis. Am J Rhinol Allergy. 2015;29(4):e100-e104. DOI: 10.2500/ajra.2015.29.4214
Jung CG, Lee JH, Ban GY, Park HS, Shin YS. Prevalence and clinical characteristics of local allergic rhinitis to house dust mites. Yonsei Med J. 2017;58(5):1047-1050. DOI: 10.3349/ymj.2017.58.5.1047
Tao XY, Ng CL, Chen D, Lin Z Bin, Wu SL, Liang MJ, et al. Clinical characteristics and allergen sensitization patterns of patients with local allergic rhinitis in Southern China. Int Arch Allergy Immunol. 2018;175(1-2):107-113. DOI: 10.1159/000485896
Hamizan AW, Rimmer J, Alvarado R, Sewell WA, Kalish L, Sacks R, et al. Positive allergen reaction in allergic and nonallergic rhinitis: A systematic review. Int Forum Allergy Rhinol. 2017;7(9):868-877. DOI: 10.1002/alr.21988
Rondón C, Campo P, Galindo L, Blanca-López N, Cassinello MS, Rodríguez-Bada JL, et al. Prevalence and clinical relevance of local allergic rhinitis. Allergy. 2012;67(10):1282-1288. DOI: 10.1111/all.12002
Altıntoprak N, Kar M, Bayar Muluk N, Oktemer T, Ipci K, Birdane L, et al. Update on local allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2016;87:105-109. DOI: 10.1016/j.ijporl.2016.06.008
Rondón C, Campo P, Zambonino MA, Blanca-López N, Torres MJ, Meléndez L, et al. Follow-up study in local allergic rhinitis shows a consistent entity not evolving to systemic allergic rhinitis. J Allergy Clin Immunol. 2014;133(4):1026-1031. DOI: 10.1016/j.jaci.2013.10.034
Cruz-Niesvaara D, Rondón C, Almeida-Quintana L, Correa A, Castillo-Sainz R, Meléndez L, et al. Evidence of local allergic rhinitis in areas with high and permanent aeroallergens exposure. J Allergy Clin Immunol. 2012;129(2):AB111. DOI: https://doi.org/10.1016/j.jaci.2011.12.547
Ha EK, Na MS, Lee S, Baek H, Lee SJ, Sheen YH, et al. Prevalence and clinical characteristics of local allergic rhinitis in children sensitized to house dust mites. Int Arch Allergy Immunol. 2017;174(3-4):183-189. DOI: 10.1159/000481091
Buntarickpornpan P, Veskitkul J, Pacharn P, Visitsunthorn N, Vichyanond P, Tantilipikorn P, et al. The proportion of local allergic rhinitis to Dermatophagoides pteronyssinus in children. Pediatr Allergy Immunol. 2016;27(6):574-579. DOI: 10.1111/pai.12606
López S, Rondón C, Torres MJ, Campo P, Canto G, Fernández R, et al. Immediate and dual response to nasal challenge with Dermatophagoides pteronyssinus in local allergic rhinitis. Clin Exp Allergy. 2010;40(7):1007-1014. DOI: 10.1111/j.1365-2222.2010.03492.x
Powe DG, Groot-Kormelink T, Sisson M, Blokhuis BJ, Kramer MF, Jones NS, et al. Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis. J Allergy Clin Immunol. 2010;125(1-3):139-145.e3. DOI: 10.1016/j.jaci.2009.07.025
Durham SR, Gould HJ, Thienes CP, Jacobson MR, Masuyama K, Rak S, et al. Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol. 1997;27(11):2899-2906. DOI: 10.1002/eji.1830271123
Khan DA. Allergic rhinitis with negative skin tests: Does it exist? Allergy Asthma Proc. 2009;30(5):465-469. DOI: 10.2500/aap.2009.30.3265
Gómez E, Campo P, Rondón C, Barrionuevo E, Blanca-López N, Torres MJ, et al. Role of the basophil activation test in the diagnosis of local allergic rhinitis. J Allergy Clin Immunol. 2013;132(4):975-976. DOI: 10.1016/j.jaci.2013.07.016
Rondón C, Doña I, López S, Campo P, Romero JJ, Torres MJ, et al. Seasonal idiopathic rhinitis with local inflammatory response and specific IgE in absence of systemic response. Allergy. 2008;63(10):1352-1358. DOI: 10.1111/j.1398-9995.2008.01695.x
Kim YH, Park CS, Jang TY. Immunologic properties and clinical features of local allergic rhinitis. J Otolaryngol Head Neck Surg. 2012;41(1):51-57. DOI: 10.2310/7070.2011.110219
Gelardi M, Quaranta N, Passalacqua G. When sneezing indicates the cell type. Int Forum Allergy Rhinol. 2013;3(5):393-398. DOI: 10.1002/alr.21119
Chang GU, Jang TY, Kim KS, Choi H, Kim YH. Nonspecific hyper-reactivity and localized allergy: Cause of discrepancy between skin prick and nasal provocation test. Otolaryngol Head Neck Surg. 2014;150(2):194-200. DOI: 10.1177/0194599813514512
Augé J, Vent J, Agache I, Airaksinen L, Campo-Mozo P, Chaker A, et al. EEAACI Position Paper on the Standardization of Nasal Allergen Challenges. Allergy. 2018;73(8):1597-1608. DOI: 10.1111/all.13416
Pepper AN, Ledford DK. Nasal and ocular challenges. J Allergy Clin Immunol. 2018;141(5):1570-1577. DOI: 10.1016/j.jaci.2017.11.066
Bozek A, Ignasiak B, Kasperska-Zajac A, Scierski W, Grzanka A, Jarzab J. Local allergic rhinitis in elderly patients. Ann Allergy, Asthma Immunol. 2015;114(3):199-202. DOI: 10.1016/j.anai.2014.12.013
Rondón C, Romero JJ, López S, Antúnez C, Martín-Casañez E, Torres MJ, et al. Local IgE production and positive nasal provocation test in patients with persistent nonallergic rhinitis. J Allergy Clin Immunol. 2007;119(4):899-905. DOI: 10.1016/j.jaci.2007.01.006
Badran HS, Hussein A, Salah M, Lotfi WT. Identification and prevalence of allergic, nonallergic, and local allergic rhinitis patients in western area, Saudi Arabia. Ann Otol Rhinol Laryngol. 2016;125(8):634-643. DOI: 10.1177/0003489416642785
Saricilar EC, Hamizan A, Alvarado R, Rimmer J, Sewell W, Tatersall J, et al. Optimizing protein harvest from nasal brushings for determining local allergy responses. 2018;32(4):244-251. DOI: 10.1177/1945892418777668
Meng Y, Lou H, Wang Y, Wang C, Zhang L. The use of specific immunoglobulin E in nasal secretions for the diagnosis of allergic rhinitis. Laryngoscope. 2018;128(9):E311-E315. DOI: 10.1002/lary.27120
Article O, Colavita L, Catalano N, Sposito G, Loddo S, Galletti B, et al. Local allergic rhinitis in pediatric patients: Is IgE dosage in nasal lavage fluid a useful diagnostic method in children? Int J Mol Cell Med. 2017;6(3):174-182. DOI: 10.22088/acadpub.BUMS.6.3.174
Campo P, Plaza-Serón MC, Eguiluz-Gracia I, Verge J, Galindo L, Barrionuevo E, et al. Direct intranasal application of the solid phase of ImmunoCAP® increases nasal specific immunoglobulin E detection in local allergic rhinitis patients. Int Forum Allergy Rhinol. 2018;8(1):15-19. DOI: 10.1002/alr.22039
Clement PAR, Gordts F. Consensus report on acoustic rhinometry and rhinomanometry. Rhinology. 2005;43(3):169-179. Disponible en: https://pdfs.semanticscholar.org/7fd0/fbd4af963a15537283884f2bdad66d25135a.pdf
Rondón C, Doña I, Torres MJ, Campo P, Blanca M. Evolution of patients with nonallergic rhinitis supports conversion to allergic rhinitis. J Allergy Clin Immunol. 2009;123(5):1098-102. DOI: 10.1016/j.jaci.2009.02.018
Rondón C, Campo P, Eguiluz-Gracia I, Plaza C, Bogas G, Galindo P, et al. Local allergic rhinitis is an independent rhinitis phenotype: the results of a 10-year follow-up study. Allergy. 2018;73(2):470-478. DOI: 10.1111/all.13272
Rondón C, Campo P, Salas M, Aranda A, Molina A, González M, et al. Efficacy and safety of D. Pteronyssinus immunotherapy in local allergic rhinitis: a double-blind placebo-controlled clinical trial. Allergy. 2016;71(7):1057-1061. DOI: 10.1111/all.12889
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