Vol. 70 No. 3 (2023)

−ABOUT THE COVER−

Hereditary angioedema (HAE) is characterized by transient and recurrent episodes of swelling in submucosal and/or subcutaneous tissues. There are three different types: Types I and II originate from abnormalities in the SERPING1 gene, which encodes C1-INH, following an autosomal dominant inheritance pattern, although they can also result from a de novo mutation. The third type is HAE with normal C1-INH, linked to various genetic mutations, six of which have been reported to date.

The lack of information about this disease and the limited or nonexistent knowledge among some physicians make early diagnosis and timely treatment difficult. Real-world data show that, on average, patients consult nine doctors and may take up to 20 years to receive a correct diagnosis.

HAE episodes have a significant negative impact on quality of life, especially in patients with laryngeal involvement, which is associated with high mortality. Swelling in other areas such as the eyes, lips, arms, abdomen, legs, feet, and genitals also leads to significant disruption of daily activities, including walking, exercising, working, attending social gatherings, traveling, and even engaging in sexual activity. Consequently, patients with HAE often isolate themselves from their family, social, and professional environments, which can lead to anxiety and depression.

For this reason, it is essential to strengthen the knowledge of primary care physicians about these rare diseases to ensure early diagnosis and treatment for HAE patients in Mexico.

Brief description of the cover: Dr. Yareli Odemaris Buendía López (author of the article: Hereditary angioedema: Patient journey approach in Mexico).

Special acknowledgment for the creation and design of the cover: DG. Diana Gabriela Salazar Rodríguez.